Methodological aspects of cognitive dysfunction diagnosis in patients with systemic lupus erythematosus

Authors: R. Svobodová 1;  M. Pošmurová 1;  P. Kozelek 2;  M. Olejárová 1
Authors‘ workplace: Revmatologický ústav Praha, 2Psychiatrická klinika VFN Praha 1
Published in: Čes. Revmatol., 18, 2010, No. 1, p. 42-47.
Category: Overview Reports


Systemic lupus erythematosus (SLE) is a chronic autoimmune disease with a broad spectrum of manifestations. Involvement of the nervous system is present in up to 80% of patients with SLE. Diagnosis of neuropsychiatric involvement (NPSLE) is very difficult with regard to a variety of clinical symptoms. Cognitive dysfunction (CD) is one of the most common manifestations of NPSLE. Its cause has not yet been entirely elucidated; a possible role of various autoantibodies, inflammatory mediators, vascular abnormalities, and neuropeptides has been discussed. Diagnosis of cognitive dysfunction is based on the testing of all substantial areas of cognitive functions: perception, attention, memory, motoric and verbal abilities, problem solving, and executive (controlling, also performing) functions (abilities to plan, act effectively, and achieve a goal) are evaluated.

Key words:
systemic lupus erythematosus, neuropsychiatric involvement, cognitive


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