Serum level of hyaluronic acid – a marker with a predictive value for radiographic progression of hand osteoarthritis


Authors: M. Filková 1;  L. Šenolt 1;  M. Braun 1;  H. Hulejová 1;  A. Pavelková 1;  O. Šléglová 1;  K. Kupka 2;  J. Gatterová 1;  K. Pavelka 1
Authors‘ workplace: Revmatologický ústav, Experimentální laboratoř pro výzkum pojiva, Revmatologická klinika 1. LF UK, Praha 1;  Ústav nukleární medicíny 1. LF UK a VFN, Praha 2
Published in: Čes. Revmatol., 17, 2009, No. 4, p. 184-190.
Category: Original Papers

Overview

Background:
Hyaluronic acid (HA) is considered a potential biomarker of progression of knee osteoarthritis (OA). The aim of this study was to measure the serum levels of HA in patients with erosive and non-erosive hand OA, and to determine its association with the disease specific structural changes.

Methods:
Fifty-five women with erosive and 33 with non-erosive OA underwent clinical examination and functional tests. Eighty-one patients underwent three-phase bone scintigraphy in order to determine the inflammation and remodeling of hand joints. Radiographs of hands were performed at baseline and after 2 years. Serum levels of HA were measured by ELISA.

Results:
Women only were included in this study. Both groups were comparable in terms of age, disease duration, BMI and inflammatory markers. The serum levels of HA correlated with age and disease duration. After adjustment for age and disease duration, HA serum levels were still higher in patients with erosive than non-erosive OA, and correlated with the number of joints with deviations and deformities. Furthermore, the serum levels of HA were associated with joint remodeling as assessed by late phase scintigraphy, and correlated with the severity of radiographic changes at baseline and after 2 years.

Conclusion:
The serum level of HA is increased in patients with erosive compared to patients with non-erosive hand OA. It is associated with local structural changes and may be regarded as a biomarker with a predictive value for radiographic progression of hand OA.

Key words:
hyaluronic acid, biomarker, erosive osteoarthritis, scintigraphy


Sources

1. Zhang W, Doherty M, Leeb BF, Alekseeva L, Arden NK, Bijlsma JW, Dincer F, Dziedzic K, Hauselmann HJ, Kaklamanis P, Kloppenburg M, Lohmander LS, Maheu E, Martin-Mola E, Pavelka K, Punzi L, Reiter S, Smolen J, Verbruggen G, Watt I, Zimmermann-Gorska I; ESCISIT. EULAR evidence-based recommendations for the diagnosis of hand osteoarthritis: report of a task force of ESCISIT. Ann Rheum Dis 2009; 68(1): 8–17.

2. Spector TD, Hart DJ, Nandra D, Doyle DV, Mackillop N, Gallimore JR, Pepys MB. Low-level increases in serum C-reactive protein are present in early osteoarthritis of the knee and predict progressive disease. Arthritis Rheum 1997; 40(4): 723–7.

3. Sowers M, Jannausch M, Stein E, Jamadar D, Hochberg M, Lachance L. C-reactive protein as a biomarker of emergent osteoarthritis. Osteoarthritis Cartilage 2002; 10(8): 595–601.

4. Pearle AD, Scanzello CR, George S, Mandl LA, DiCarlo EF, Peterson M, Sculco TP, Crow MK. Elevated high-sensitivity C-reactive protein levels are associated with local inflammatory findings in patients with osteoarthritis. Osteoarthritis Cartilage 2007; 15: 516–23.

5. Olejarova M, Kupka K, Pavelka K, Gatterova J, Stolfa J. Comparison of clinical, laboratory, radiographic, and scintigraphic findings in erosive and nonerosive hand osteoarthritis. Results of a two-year study. Joint Bone Spine 2000; 67: 107–12.

6. Punzi L, Ramonda R, Oliviero F, Sfriso P, Mussap M, Plebani M, Podswiadek M, Todesco S. Value of C reactive protein in the assessment of erosive osteoarthritis of the hand. Ann Rheum Dis 2005; 64(6): 955–7.

7. Cicuttini FM, Baker JR, Spector TD. The association of obesity with osteoarthritis of the hand and knee in women: a twin study. J Rheumatol 1996; 23: 1221–6.

8. Thonar EJ. Molecular markers of metabolic changes in osteoarthritis. Osteoarthritis Cartilage 1999; 7(3): 338–9.

9. Garnero P, Piperno M, Gineyts E, Christgau S, Delmas PD, Vignon E. Cross sectional evaluation of biochemical markers of bone, cartilage, and synovial tissue metabolism in patients with knee osteoarthritis: relations with disease activity and joint damage. Ann Rheum Dis 2001; 60(6): 619–26.

10. Rousseau JC, Delmas PD. Biological markers in osteoarthritis. Nat Clin Pract Rheumatol 2007; 3(6): 346–56.

11. Uebelhart D, Williams JM. Effects of hyaluronic acid on cartilage degradation. Curr Opin Rheumatol. 1999; 11(5): 427–35.

12. Salisbury C, Sharif M. Relations between synovial fluid and serum concentrations of osteocalcin and other markers of joint tissue turnover in the knee joint compared with peripheral blood. Ann Rheum Dis 1997; 56(9): 558–61.

13. Sharif M, George E, Shepstone L, Knudson W, Thonar EJ, Cushnaghan J, Dieppe P. Serum hyaluronic acid level as a predictor of disease progression in osteoarthritis of the knee. Arthritis Rheum 1995; 38(6): 760–7.

14. Turan Y, Bal S, Gurgan A, Topac H, Koseoglu M. Serum hyaluronan levels in patients with knee osteoarthritis. Clin Rheumatol 2007; 26(8): 1293–8.

15. Pavelka K, Forejtová S, Olejárová M, Gatterová J, Senolt L, Spacek P, Braun M, Hulejová M, Stovícková J, Pavelková A. Hyaluronic acid levels may have predictive value for the progression of knee osteoarthritis. Osteoarthritis Cartilage 2004; 12(4): 277–83.

16. MaziŹres B, Garnero P, Guéguen A, Abbal M, Berdah L, Lequesne M, Nguyen M, Salles JP, Vignon E, Dougados M. Molecular markers of cartilage breakdown and synovitis at baseline as predictors of structural progression of hip osteoarthritis. The ECHODIAH Cohort. Ann Rheum Dis 2006; 65(3): 354–9.

17. Altman R, Alarcón G, Appelrouth D, Bloch D, Borenstein D, Brandt K, Brown C, Cooke TD, Daniel W, Gray R, et al. The American College of Rheumatology criteria for the classification and reporting of osteoarthritis of the hand. Arthritis Rheum 1990; 33: 1601–10.

18. Filková M, Lisková M, Hulejová H, Haluzík M, Gatterová J, Pavelková A, Pavelka K, Gay S, Müller-Ladner U, Šenolt L. Increased serum adiponectin levels in female patients with erosive compared with non-erosive osteoarthritis, Ann Rheum Dis 2009: 68: 295–296.

19. Bellamy N, Campbell J, Haraoui B, Gerecz-Simon E, Buchbinder R, Hobby K, MacDermid JC. Clinimetric properties of the AUSCAN Osteoarthritis Hand Index; an evaluation of reliability, validity and responsiveness. Osteoarthritis Cartilage 2002; 10(11): 863–9.

20. Dreiser RL, Maheu E, Guillou GB, Caspard H, Grouin JM. Validation of an algofunctional index for osteoarthritis of the hand. Rev Rhum Engl Ed 1995; 62(6 Suppl 1): 43S–53S.

21. Kallman DA, Wigley FM, Scott WW Jr, Hochberg MC, Tobin JD. New radiographic grading scales for osteoarthritis of the hand. Reliability for determining prevalence and progression. Arthritis Rheum 1989; 32(12): 1584–91.

22. Pavelka K, Gatterová J, Gollerova V, Urbanová Z, Sedlácková M, Altman RD. A 5-year randomized controlled, double-blind study of glycosaminoglycan polysulphuric acid complex (Rumalon) as a structure modifying therapy in osteoarthritis of the hip and knee. Osteoarthritis Cartilage 2000; 8(5): 335–42.

23. Kellgren JH, Lawrence JS. Radiological assessment of osteo-arthrosis. Ann Rheum Dis 1957; 16(4): 494–502.

24. Punzi L, Ramonda R, Sfriso P. Erosive osteoarthritis. Best Pract Res Clin Rheumatol 2004; 18: 739–58.

25. Maheu E, Michon M, Carrat F, Berenbaum F. Erosive versus non erosive hand OA: Prospective cross-sectional comparison of clinical data. Ann Rheum Dis 2008; 67 (Suppl II): 94.

26. Balazs EA, Watson D, Duff IF, Roseman S. Hyaluronic acid in synovial fluid. I. Molecular parameters of hyaluronic acid in normal and arthritis human fluids. Arthritis Rheum 1967; 10(4): 357–76.

27. Baker MS, Green SP, Lowther DA. Changes in the viscosity of hyaluronic acid after exposure to a myeloperoxidase-derived oxidant. Arthritis Rheum 1989; 32(4): 461–7.

28. Saari H, Sorsa T, Konttinen YT. Reactive oxygen species and hyaluronate in serum and synovial fluid in arthritis. Int J Tissue React 1990; 12(2): 81–9.

29. Al-Assaf S, Navaratnam S, Parsons BJ, Phillips GO. Chain scission of hyaluronan by peroxynitrite. Arch Biochem Biophys 2003; 411(1): 73–82.

30. Belcher C, Yaqub R, Fawthrop F, Bayliss M, Doherty M. Synovial fluid chondroitin and keratan sulphate epitopes, glycosaminoglycans, and hyaluronan in arthritic and normal knees. Ann Rheum Dis 1997; 56(5): 299–307.

31. Dahl LB, Dahl IM, Engström-Laurent A, Granath K. Concentration and molecular weight of sodium hyaluronate in synovial fluid from patients with rheumatoid arthritis and other arthropathies. Ann Rheum Dis 1985; 44(12): 817–22.

32. Nishida Y, D’Souza AL, Thonar EJ, Knudson W. Stimulation of hyaluronan metabolism by interleukin-1alpha in human articular cartilage. Arthritis Rheum 2000; 43(6): 1315–26.

33. Maleski MP, Knudson CB. Matrix accumulation and retention in embryonic cartilage and in vitro chondrogenesis. Connect Tissue Res 1996; 34(1): 75–86.

34. Ohno S, Im HJ, Knudson CB, Knudson W. Hyaluronan oligosaccharide-induced activation of transcription factors in bovine articular chondrocytes. Arthritis Rheum 2005; 52(3): 800–9.

35. Iacob S, Knudson CB. Hyaluronan fragments activate nitric oxide synthase and the production of nitric oxide by articular chondrocytes. Int J Biochem Cell Biol 2006; 38(1): 123–33.

36. Knudson W, Casey B, Nishida Y, Eger W, Kuettner KE, Knudson CB.Hyaluronan oligosaccharides perturb cartilage matrix homeostasis and induce chondrolysis. Arthritis Rheum 2000; 43(5): 1165–74.

37. Noble PW, McKee CM, Cowman M, Shin HS. Hyaluronan fragments activate an NF-kappa B/I-kappa B alpha autoregulatory loop in murine macrophages. J Exp Med 1996; 183(5): 2373–8.

38. Chen HC, Shah S, Stabler TV, Li YJ, Kraus VB. Biomarkers associated with clinical phenotypes of hand osteoarthritis in a large multigenerational family: the CARRIAGE family study. Osteoarthritis Cartilage 2008; 16(9): 1054–9.

39. Silvestri T, Pulsatelli L, Dolzani P, Punzi L, Meliconi R. Analysis of cartilage biomarkers in erosive and non-erosive osteoarthritis of the hands. Osteoarthritis Cartilage 2004; 12(10): 843–5.

40. Bruyere O, Collette JH, Ethgen O, Rovati LC, Giacovelli G, Henrotin YE, Seidel L, Reginster JY. Biochemical markers of bone and cartilage remodeling in prediction of longterm progression of knee osteoarthritis. J Rheumatol 2003; 30(5): 1043–50.

41. Bruyere O, Collette J, Kothari M, Zaim S, White D, Genant H, Peterfy C, Burlet N, Ethgen D, Montague T, Dabrowski C, Reginster JY. Osteoarthritis, magnetic resonance imaging, and biochemical markers: a one year prospective study. Ann Rheum Dis 2006; 65(8):

Labels
Dermatology & STDs Paediatric rheumatology Rheumatology
Login
Forgotten password

Don‘t have an account?  Create new account

Forgotten password

Enter the email address that you registered with. We will send you instructions on how to set a new password.

Login

Don‘t have an account?  Create new account