Increased serum levels of adiponectin in patients with erosive osteoarthritis

Authors: M. Filková 1;  M. Lišková 1;  H. Hulejová 1;  M. Haluzík 2;  J. Gatterová 1;  K. Pavelka 1;  L. Šenolt 1
Authors‘ workplace: Revmatologický ústav, Praha, 2III. interní klinika VFN a 1. LF UK, Praha 1
Published in: Čes. Revmatol., 16, 2008, No. 3, p. 100-103.
Category: Original Papers


Adipocytokines are peptides derived from adipose tissue, which are related to complications of obesity. Although obesity represents a significant risk factor of osteoarthritis, there is not much data on relationship between adipocytokines and osteoarthritis, to date.

The aim of the study was to compare levels of selected adipocytokines, adiponectin and resistin, in patients with erosive and nonerosive osteoarthritis of small hand joints.

Patients and methods:
The studied group consisted of 48 patients with erosive osteoarthritis, 27 patients with nonerosive osteoarthritis and 20 healthy volunteers. Sixty-one patients had skeletal scintigraphy in order to determine the inflammation of small hand joints. The serum levels of adipocytokines were measured by ELISA.

Women only were selected in the study. Their mean age and body mass index, including the prevalence of osteoarthritis of knee and hip joints did not significantly differ. Serum levels of adiponectin were significantly increased in patients with erosive compared to nonerosive osteoarthritis. Levels of resistin and CRP did not significantly differ between the groups of patients with osteoarthritis of small hand joints. Neither serum adiponectin, nor resistin correlated with CRP and had a relationship to inflammation found on three-phase skeletal scintigraphy.

Increased levels of adiponectin in patients with erosive osteoarthritis, in comparison to nonerosive type, might have some application in the pathogenesis of destructive process.

Key words:
adipocytokines, adiponectin, resistin, erosive osteoarthritis, inflammation


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Dermatology & STDs Paediatric rheumatology Rheumatology
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