Authors: J. Vachtenheim; A. Houzarová Authors‘ workplace: Revmatologická ordinace, interní oddělení, Krajská nemocnice, Jihlava Published in: Čes. Revmatol., 16, 2008, No. 3, p. 124-127. Category: Case Report
The present contribution describes a patient with pachydermoperiostosis, a rare disease associated with hyperperiostosis (occuring predominantly in long bones of forearms and shanks), and clubbing of the digits of the hands and feet. Patients frequently have arthralgia of both the small and large joints. The diagnosis is based on X-ray and clinical observations. Laboratory examination often shows unspecific changes such as elevated erythrocyte sedimentation and C-reactive protein level. Similar X-ray and clinical finding should be considered in the differential diagnosis, which include malignancies (most frequently lung and gastrointestinal cancer), but also, for instance, inherited heart defects. The disease can be diagnosed with the aid of X-ray and laboratory examination, however. We present a case report of our second patient with typical symptoms of this rare disease. Our first observation has been described as early as in 1960.
Key words: pachydermoperiostosis, incidence, clinical picture
1. Charvát J, Mařátka Z. Hyperostosis generalisata cum pachydermia. Čas Lék čes 1946; 15 : 508–516.
2. Miková D. Pachydermoperiostóza–vývoj kostních změn po 25 letech od počátku nemoci. Vnitř Lék 1989; 35 : 68–73.
3. Vachtenheim J, Pánek Z. Die Pachydermoperiostose. Radiol Diagn 1960; 1 : 473–479.
4. Anandacoomarasamy A, Bak HS, Peduto A, et al. Magnetic resonance imaging in pachy-dermodactyly. J Rheumatol 2005; 32 : 2239–41.
5. Castori M, Sinibaldi L, Mingarelli L, et al. Pachydermoperiostosis: an update. Clin Genet 2005; 68 : 477–486.
6. Dudová N. Hyperostosis generalisata cum pachydermia. Vnitř Lék 1958; 4 : 345–349.
7. Grepl J. Pachydermoperiostitis. Srovnání dvou pozorování v různém evolučním stadiu. Čs Radiol 1979; 33 : 183–190.
8. Janečka V, Bruna J. Pachydermoperiostitis. Čs Radiol 1974; 28 : 353–359.
9. Štěpánek V, Metelka J. Generalizovaná hyperostóza s pachydermií a s hypertrofií sliznice trávicí trubice. Čs Rentgenol 1958; 12 : 246–249.
10. Točík J. Leukoplakia a pachydermia sliznice hlasivek. Čs Otolaryng 1953;32 : 312–315.
11. Schroder K, Goerdt S, Sieper J, et al. Psoriatic onycho-periostitis (POOP). Hautarzt 1997; 48 : 500–505.
12. Bachmeyer C, Blum L, Cadranel JF, Delfraissy JF. Myelofibrosis in a patient with pachy-dermoperiostosis. Clin Exp dermatol 2005; 30 : 646–648.
13. Toepfer M, Rieger J, Pfluger T, et al. Primary hypertrophic osteoarthropathy (Touraine-So lente-Gole Syndrom). Dtsch Med wschr 2002; 127 : 1013–16.
14. Rezgui-Marhout L, Edouira-Khomsi W, Bouslama K, et al. Pachydermoperiostosis, a report of two cases. J Radiol 2005; 86 : 340–343.
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