Ways of protection of reproductive functions of women and men undergoing treatment with cytotoxic drugs

Authors: P. Němec 1;  M. Huser 2;  M. Souček 3
Authors‘ workplace: Revmatologická ambulance, II. interní klinika Lékařské fakulty Masarykovy Univerzity a FN u sv. Anny v Brně 1;  Centrum asistované reprodukce CAR 01, Gynekologicko-porodnická klinika Lékařské fakulty Masarykovy Univerzity a FN Brno, 3II. interní klinika Lékařské fakulty Masarykovy Univerzity a FN u sv. Anny v Brně 2
Published in: Čes. Revmatol., 16, 2008, No. 2, p. 81-88.
Category: Overview Reports


Therapy of serious organ affections in connective tissue diseases and systemic vasculitides often requires the use of cytostatics. Irreversible damage of gonads’ germinal tissue belongs to serious adverse effects of these drugs. Destruction of ovarian follicles leads to the primary ovarian insufficiency and to the development of subsequent infertility with symptoms of climacteric syndrome. Destruction of testicles can even lead to permanent azoospermia. The question of protection of reproductive functions of women and men has not been entirely answered yet. The overview of present ways of protection of reproductive functions of women and men undergoing the treatment with cytotoxic drugs including modern methods of assisted reproduction and new ways of pharmacological protection using gonadoliberin analogs is described in the text.

Key words:
assisted reproduction, GnRH analogs, infertility, connective tissue disease


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