The Role of Cyclooxygenase-2 in Non-inflammatory Processes
Revmatologický ústav, Praha
Čes. Revmatol., , 2002, No. 3, p. 117-124.
The only iso-form of cyclooxygenase expressed in thrombocytes is cyclooxygenase-1. In endothelialcells and in smooth muscle cells of the vascular wall both iso-forms are expressed. Selectiveinhibition of cyclooxygenase-2 by coxibs in the vascular system deprives this class of non-steroidantirheumatics of their anti-aggregation effect. At present a discussion is under way on the „prothrombogenicpotential“ of coxibs, which however so far was not unequivocally proved.On the otherhand the antiphlogistic effect of coxibs could have a favourable impact on the „inflammatorycomponent“ in the genesis of atherosclerosis. Further investigations are needed for evaluation ofthese problems.
cyclooxygenase-1, cyclooxygenase-2, prothrombogenic potential, cardiovascularrisk, cardiovascular safety
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