Analysisof Clinical and Laboratory Data in a Group of Patients with Juvenile Idiopathic Arthritis (JIA)inThe Framework of the National Register

Authors: K. Jarošová;  Ga T T E R O Vá J.;  D. Němcová;  Va V Řincová P.;  Br E J Chová I.;  V. Lád;  Mi N X O V Á L .;  Ně Me C V.;  Z. V Á R O V Á J.;  Ky L O U Š K O V Á M.;  Ci Ml E R O V Á P.
Authors‘ workplace: Revmatologický ústav, Praha Klinika dětského a dorostového lékařství 1. LF UK a VFN v Praze, Dětská klinika 2. LF UK a FN, Praha-Motol, Dětské oddělení nemocnice České Budějovice, Dětská klinika FN, Plzeň, Dětská klinika LF UK a FN, Hradec Králové, 6 Děts
Published in: Čes. Revmatol., , 2002, No. 2, p. 65-70.


Objective .
The objective of the presented work was to analyze data from the nationwide register ofinflamatory rheumatic diseases which comprises also a group with juventile idiopathic arthritis.Method .The authors evaluated data froma total of 407 patients with JIA.The whole group of patientswas divided into subgroups according to the last classification (Durban,1997).In the whole groupand in individual subgroups they evaluated clinical data (type of articular affection,systemicsymptoms,opthalmological and skin manifestations,functional affections),some laboratory para-meters and X-ray changes.Contemporary treatment was elaborated in greater detail,i.e.corticos-teroid therapy as well as treatment with drugs modifying the disease.Results .The results confirmedthe great heterogeneity of the disease.Serious functional affections at the time of registration wereobserved in 44 patients (10.8 %,functional class c+d ).After classification of patients into subgroupsthe most severe functional affection was observed in systemic arthritis,where functional class c wasrecorded in 12 (30.0 %)patients.Advanced X-ray changes were present in 109 (26.8 %)patients,mostfrequently in seropositive polyarthritis (23;63.9 %).Uveitis was diagnosed in 41 (10.1 %)patients,in28 (6.9 %)chronic uveitis and in 13 (3.2 %)acute uveitis.Complications,such as synechiae,zonularkeratopathies and cataract or glaucoma were present in 18 (4.4 %)of the patients with JIA.Contemporary treatment with oral corticosteroids was recorded in 186 (45.7 %)patients with JIA,in particular in systemic arthritis (35;87.5 %)and seropositive polyarthritis (19;52.8 %).As to diseasemodifying druha,methotrexate was administered most frequently on half of the patients with JIA(200;50.6 %),and sulfasalazine (128;31.5 %).As to orthopaedic operations total endoprostheses wereimplanted in 22 (5.4 %)and synovectomies in 57 (14.1 %)JIA.Conclusion .The first analysis of datafrom the nationwide register indicates that JIA is a serious disease and that in a great proportionof patients it leads to functional affection and advanced X-ray changes.

Key words:
register of rheumatic diseases,juvenile idiopathic arthritis,uveitis,therapy

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Dermatology & STDs Paediatric rheumatology Rheumatology
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