Genetics of Autoimmune Disease I. Rheumatoid Arthritis
Š. Růžičková 1,2; J. Vencovský 2,1
Laboratoř genové exprese, 3. lékařská fakulta UK, Praha 2 Revmatologický ústav, Praha
Čes. Revmatol., , 2001, No. 1, p. 14-20.
Rheumatoid arthritis is a chronic systemic autoimmune disease characterized by inflammation ofthe joints, extraarticular involvement and the production of autoantibodies. In the affected jointsproliferation of the synovial membrane occurs as well as neovascularization and infiltration ofdifferent cell types. Clinically rheumatoid arthritis is manifested as a heterogeneous disease andtherefore it is not easy to investigate its genetic background. The genetic basis of rheumatoidarthritis is very complex with a significant contribution of molecules of the main histocompatibilitycomplex. The authors discuss the part played by these genetic factors as well as the polymorphismof genes for some cytokines, immunoglobulins and the T cell receptor in the pathogenesis ofrheumatoid arthritis.
rheumatoid arthritis, genetic predisposition, genes, polymorphism, HLA, TNF-al-pha, TCR, Ig
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Dermatology & STDs