Acute immune trobocytopenic purpura in pregnant adolescent

Authors: T. Binder 1;  J. Biolek 2;  A. Srbová 3;  D. Procházková 4;  A. Vašková 5;  F. Fadi 1;  M. Pánek 6
Authors‘ workplace: Gynekologicko-porodnická klinika UJEP a Masarykovy nemocnice, Ústí nad Labem, přednosta doc. MUDr. T. Binder, CSc. 1;  Dětské a dorostové oddělení nemocnice Most, primářka MUDr. M. Váchová 2;  Ústav hematologie a krevní transfuze, Praha, ředitel prof. MUDr. P. Cetkovský, Ph. D., MBA 3;  Dětská klinika UJEP a Masarykovy nemocnice, Ústí nad Labem, přednosta MUDr. J. Škvor, CSc. 4;  Oddělení klinické hematologie Masarykovy nemocnice, Ústí nad Labem, primářka MUDr. J. Ullrychová 5;  Neonatologická klinika UJEP a Masarykova nemocnice, Ústí nad Labem, přednosta MUDr. P. Hitka, Ph. D. 6
Published in: Ceska Gynekol 2019; 84(6): 443-449


Objective: The article reviews the causes of thrombocytopenia in pregnancy and the basic examination scheme. Further, it deals in more details with diagnosis of immune thromocytopenic purpura (ITP) and presents a case report of a rare case of acute severe ITP in pregnant adolescent.

Design: Review article and case report.

Settings: Department Obstet/Gynecol Uni J. A. Purkyně and Masaryk´s Hospital, Ústí nad Labem; Children and adolescent dep. Hospital Most; Institute of Hematology and Blood Transfusion Prague; Department of Children Med. Uni J. A. Purkyně and Masaryk´s Hospital, Ústí nad Labem; Department of Clinic Hematology Masaryk´s Hospital, Ústí nad Labem; Department of Neonatology Uni J. A. Purkyně and Masaryk´s Hospital, Ústí nad Labem.

Methods: Based on a review of the published papers, general rules for diagnosis, treatment, fetal risks, pregnancy management and labor in women with immune thrombocytopenic purpura (ITP) are given. Further we present the case of a 16-year-old pregnant girl with an acute severe form of ITP not responding to corticosteroid treatment who underwent twice critical decline of platelets up to 1×109 and repeatedly it was necessary to access the application of IVIG and Azathioprim (Imuran) was also used in her treatment. Pregnancy was unplanned terminated for dg. placental abortion in gestational age 32+4.The girl of 1740 g/42 cm was born with Apgar score 10–10–10 with no signs of thrombocytopenia. Surgery and postoperative course in the mother without complications. The newborn was discharged from the hospital into home care at a gestational age of 36+1 along with his mother.

Results: We present a case of acute severe form of ITP in pregnancy with a successful though somewhat dramatic end.

Conclusions: These rare cases are demanding in terms of logistical, personnel and material provision. The aim of the treatment is to achieve a satisfactory maturity of the fetus, the treatment is financially demanding and is not without risks. Therefore, these cases should only be dealt with at Perinatology Centers in close cooperation with hematologists and neonatologists.


pregnancy – immune trobocytopenic purpura


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Paediatric gynaecology Gynaecology and obstetrics Reproduction medicine

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2019 Issue 6

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