Nine-valent HPV vaccine -⁠ new generation of HPV vaccine

Czech version

Authors: Tomáš Fait ^1,2; V. Dvořák ^1,4; R. Pilka ^1,3
Authors‘ workplace: HPV College o. s., prezident MUDr. J. Ondruš, CSc., MIAC ¹; Gynekologicko-porodnická klinika 1. LF UK a VFN, Praha, přednosta prof. MUDr. A. Martan, DrSc. ²; Porodnicko-gynekologická klinika FN a LP UP, Olomouc, přednosta prof. MUDr. R. Pilka, Ph. D. ³; Centrum ambulantní gynekologie a primární péče, Brno ⁴
Published in: Ceska Gynekol 2015; 80(6): 397-400

Overview

Objective:
To evaluate current knowledge about new generation of HPV vaccine –⁠ nine-valent vaccine Gardasil9.

Design:
Review article.

Results:
The nine-valent vaccine against HPV 6/11/16/18/31/33/45/52/58 could improve efficacy of quadrivalent vaccine from 70 to 90 percent for cervical cancer. In addition this vaccine has covered around85-90% of HPV-related vulvar, vaginal and anal cancers. Efficacy and immunogenicity against HPV 6/11/16/18 is the same as for quadrivalent vaccine. Efficacy against HPV 31/33/45/52/58 associated lesions is 97%.

Keywords:
HPV infection, prevention, nine-valent HPV vaccine

Sources

1. Castellsague, X., Guiliano, A., Goldstone, S., et al. Tolerability and immunogenicity of a multivalent HPV L1 virus-lik partije vaccine in 16 -⁠ to 26-year old men. Eurogin, 2015, abstract, p. 174.

2. Joura, AE., Guiliano, AR., Iversen, O., et al. A 9-valent HPV vaccne infekcion and intraepitelial neoplasia in woman. N Engl J Med, 2015, 372(8), p. 711–723.

3. Malagón, T., Drolet, M., Boily, MC., et al. Cross-protective efficacy of two human papillomavirus vaccines: a systematic review and meta-analysis. Lancet Infect Dis, 2012, 12, p. 781–789.

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8. Serrano, B., deSanjosé, S., Tous, S., et al. HPV genotype attribution for HPVs 6, 11, 16, 18, 31, 33, 45, 52 a 58 in female anogenital lesions. Eur J Cancer, 2015, 51(13), p. 1732–1741.

9. Schilling, A., Parra, MM., Gutierrez, M., et al. Coadmnistration of a 9-valent HPV vaccine with meningococcal and Tdap vaccine. Pediatrics, 2015, 136(3), p. 563–572.

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Labels

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Article was published in

Czech Gynaecology

2015 Issue 6