Hormonal treatment effectivity in hyperandrogenic syndrome


Authors: J. Višňovský 1;  K. Biringer 1;  I. Švecová 1;  Z. Biringerová 2
Authors‘ workplace: Gynekologicko-pôrodnícka klinika JLF UK, Martin, Slovensko, prednosta prof. MUDr. J. Danko, CSc. 1;  Klinika anesteziológie a intenzívnej medicíny JLF UK, Martin, Slovensko, prednosta doc. MUDr. B. Sániová, CSc. 2
Published in: Čes. Gynek.2010, 75, č. 5 s. 481-485

Overview

Objective:
To evaluate effectiveness of hormonal treatment of hyperandrogenic syndrome (HAS).

Design:
Prospective randomized study.

Setting:
Department of Gynecology and Obstetrics, Jessenius Faculty of Medicine, Comenius University, Martin, Slovak Republic.

Methods:
We assessed effect of one-year-long hormonal treatment on menstrual cycles (MC), clinical signs of HAS, and ultrasound finding (USG) in 90 patients with HAS. Patients were divided into three groups with 30 females: A – 35 μg ethinylestradiol (EE) with 2.0 mg cyproterone acetate/day; B – 30 μg EE with 2.0 mg dienogest/day; C – 30 μg EE with 3.0 mg drospirenone/day.

Results:
It was achieved a positive effect on MC regularity in every group during the first six months of treatment (p<0.001). Signs of hirsutism, virilization, and USG finding were significantly better in group A.

Conclusion:
The most effective hormonal treatment in our study was the combination of 35 μg EE with 2.0 mg cyproterone acetate/day.

Key words:
hyperandrogenic syndrome, HAS, PCOS, menstrual bleeding, ultrasound.


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Labels
Paediatric gynaecology Gynaecology and obstetrics Reproduction medicine
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