Proteomics and biomarkers for detection of ovarian cancer


Authors: M. Kacerovský 1;  V. Tambor 2;  J. Lenčo 2;  J. Tošner 1
Authors‘ workplace: Porodnická a gynekologická klinika FN Hradec Králové, Lékařská fakulta Hradec Králové, Univerzita Karlova Praha, přednosta doc. MUDr. J. Tošner, CSc. 1;  Ústav molekulární patologie, Fakulta vojenského zdravotnictví Univerzity Obrany Hradec Králové, přednosta prof. MUDr. J. Stulík, CSc. 2
Published in: Čes. Gynek.2009, 74, č. 3 s. 163-170

Overview

Objective:
The purpose of this study was to focuse on recent developments on the evolving field of biomarker discovery and validation techniques using proteomics platforms for ovarian cancer.

Design:
Review.

Setting:
Department of Obstetrics and Gynecology Medical Faculty Charles University Hradec Kralove. Institute of Molecular Pathology. Faculty of Military Health Sciences, University of Defense, Hradec Kralove.

Methods:
The last decade has seen major changes in the technologies used to identify markers for diagnosing early stages of ovarian cancer. Currently the major developments were made in three distinct areas: protein profilig, highthroughput validation techniques and solid and liquid phase protein microarray platforms for analyzing candidate markers across stages hold significant of ovarian cancer. These new technologies hold significant promise in identifying more robust markers for ovarian cancer.

Conclusion:
The present review summarizes the results of clinical and experimental research on biomarkers of ovarian cancer.

Key words:
proteomics, ovarian cancer, biomarker.


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