Cholecystectomy – the Risk Factors for Endometrial Carcinoma?

Overview

Aim:
The aim of this study was to find out if the incidence of cholecystectomy is more frequent in patiens with endometrial carcinoma and if the incidence of the anamnestic information concerning cholecystectomy in patiens with endometrial carcinoma influences the course and the result of the treatment of the said tumorous disease.

Type of study:
Retrospective study.

Methods:
470 females with endometrial carcinoma were entered into the study, the group was divided into the patients who have had cholecystectomy and those who have not had it. There was a control group of 370 females. All the said patients were diagnosed and subsequently treated at the Department of Gynecology and Obstetrics Masaryk University affiliated Hospital, Brno between January 2004 and December 2006.

Results:
We have not proved any statistically significant difference concerning the origin of the endometrial carcinoma after a performed cholecystectomy. There was no difference in grading as well as the stage according to the FIGO standards. Nonetheless, we can say that the patients with endometrial carcinoma and cholecystectomy have significantly higher BMI.

Conclusion:
The relation between cholecystectomy and the endometrial carcinoma can be influenced by various factors. However, we can assume that the pathological processes of cholelithiasis are pathophysiologically connected with the development of changes, which fall within the category of hormonal risk factors for the development of endometrial carcinoma.

Key words:
endometrial carcinoma, cholelithiasis, cholecystectomy, obesity, hormonal factors