Authors: J. Gruberová 1; S. Biková 1; Z. Ulčová-Gallová 1; J. Reischig 2; Z. Rokyta 1 Authors‘ workplace: Gynekologicko-porodnická klinika LF UK a FN, Plzeň, přednosta doc. MUDr. Z. Rokyta, CSc. 1; Ústav biologie LF UK, Plzeň, přednosta doc. RNDr. J. Reischig, CSc. 2 Published in: Ceska Gynekol 2006; 71(1): 36-40 Category: Original Article
Objective: We studied pH of ovulatory mucus, sperm penetration through capillary filled with ovulatory mucus in one hour and presence of local spermagglutinating antibodies.
Methods: We measured pH, arborization and Kremer test in ovulatory mucus in 127 women with fertility disorder. Indirect mixed antiimunoglobulin reaction test (i-MAR-test for IgG, IgA, IgM and IgE) was used for detection of spermagglutinating antibodies. Results: pH 7.4–9.6 (physiological limit) was found in 94/127 women (74%), pH
Summary: Pathological pH of ovulatory mucus, hormonal dysbalance, and presence of local spermagglutinating antibodies evidently influence penetration of sperm cells through cervix uteri. Otherwise pathological microbial vaginal environment can start a cross reaction with the surface microbes and sperm epitopes. One sign of ovulation, arborization of cervical ovulatory mucus, is not connected directly with the presence of local sperm antibodies, but insufficient estrogen influence is a sign of the reduced immunosuppression in cervix area.
Key words: fertility disorders, ovulatory mucus, pH, arborization, antibodies, Kremmer test, i-MAR-test
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