Breast Cancer Cell Populations and its Changes Relation to Therapy

Czech version

Authors: D. Kolařík ¹; I. Netíková ²; I. Marinov ³; I. Juliš ⁴; M. Halaška jr. ⁵; K. Rauš ¹; Daniel Driák ¹; J. Záhumenský ¹; K. Benková ⁶; M. Halaška ¹
Authors‘ workplace: Gynekologicko-porodnická klinika 1. LF UK a FN na Bulovce, Praha, přednosta prof. MUDr. M. Halaška DrSc. ¹; Onkologická klinika 1. LF UK a VFN, Praha, přednosta doc. MUDr. L. Petruželka, CSc. ²; ÚHKT, Praha, přednosta prof. MUDr. P. Klener, DrSc. ³; Biolab s. r. o., Praha ⁴; Gynekologicko-porodnická klinika 2. LF UK a FN Motol, Praha, přednosta doc. MUDr. L. Rob, CSc. ⁵; Ústav patol. a soud. lékařství, FN na Bulovce, Praha, prim. MUDr. K. Benková ⁶
Published in: Ceska Gynekol 2006; 71(1): 43-60
Category: Original Article

Overview

This review summarizes the data from published studies that dealt with observation of various bioparameters changes in cancer population dependant on used therapy. Critically evaluating these studies and looking for relations among separate results we are trying to estimate prognostic value of these parameters (likelihood of recurrence, overall survival, ...) and also their value for prediction of tumor response to cytostatic, hormonal or other treatment. The aim is selection of such tumor population characteristics the testing of them would enable better patient stratification in postoperative adjuvant systemic therapy.

Key words:
breast cancer, chemotherapy, cellular changes, hormonal therapy