Vulvovaginal Candidiasis and Susceptibility ofPathogens to Antifungal Agents
M. Sojáková 1; D. Liptajová 2; M. Šimončičová 3; M. Borovský 1; J. Šubík 2
I. gynekologicko-pôrodnícka klinika LFUK a FN, Zochova 7, 811 03 Bratislava, prednosta prof. MUDr. M. Borovský, CSc. 2Katedra mikrobiológie a virológie, Prírodovedecká fakulta, Univerzita Komenského, 842 15 Bratislava, vedúci katedry prof. RNDr. Ing. M. K
Ceska Gynekol 2003; (1): 24-29
Analysis of the prevalence and species representation of pathogenic yeasts in patientswith vulvovaginal candidiasis. Determination of in vitro susceptibility of yeast isolates to clinicallyused antimycotic agents.Design: A retrospective clinical study of patients with positive vaginal cultures for the presence ofpathogenic yeast species.Setting: I. gynekologicko-pôrodnícka klinika LF UK a FN, Zochova 7, 811 03 Bratislava, Slovenskárepublika. Methods: Identification of yeast pathogens on the chromogenic medium CHROMagar CANDIDAand with API-CANDIDA identification system. In vitro susceptibility assays of clinical yeast isolatesto antifungal agents using the plate dilution method, NCCLS method and ATB-FUNGUS testsystem.Results: The highest prevalence of vulvovaginal candidiasis was found in women aged between20–30 years. Candida albicans was the most commonly identified species of pathogenic yeasts(87.4%). Of the non-albicans species, C. glabrata (6.3%) was the most prevalent species. C. glabrataand C. krusei clinical isolates were found to be generally less susceptible to several antifungals invitro as compared to C. albicans strains. A minimal number of resistant yeast isolates was observedfor econazole, clotrimazole and nystatin. A relatively high number of resistant strains wasobserved for some other azole antifungals (miconazole, ketoconazole, itraconazole, fluconazole).Conclusion: A successful treatment of vaginal mycotic infections requires the results of the microbiologicalanalyses. They will bring evidence to a physician of the presence and fate of the pathogen,of its sensitivity to antifungals, both of which are essential for the rational and successfultherapy of Candida vaginitis.
vulvovaginal candidiasis, in vitro resistance, antifungal agents
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Gynaecology and obstetrics