Fertility after Chemotherapy of Gestational Trophoblastic Disease

Authors: M. Korbeľ 1;  Ľ. Danihel 2;  J. Vojtaššák 3;  J. Šufliarsky 4;  M. Redecha 1;  Nižňanská
Authors‘ workplace: Centrum pre trofoblastovú chorobu Slovenskej republiky (CTCH SR), vedúci doc. MUDr. M. Korbeľ, CSc. 1 I. gynekologicko-pôrodnícka klinika LFUK a FN Bratislava, prednosta doc. MUDr. M. Borovský, CSc. 2 Ústav patologickej anatómie LFUK a FN Bratislava, pred 1,2,3,4
Published in: Čes. Gynek.2000, , č. 3 s. 167-170


To evaluate subsequent pregnancy experience in patients following chemotherapy formalignant form of gestational trophoblastic disease.Design: Retrospective clinical study.Setting: Slovak Center of Trophoblastic Disease, Bratislava, Slovak Republic.Methods: There were evaluated subsequent pregnancy experiences in 38 patients after chemothe-rapy for malignant form of gestational trophoblastic disease registrated in Slovak center of gesta-tional trophoblastic disease. Histological and cytogenetical analysis of all placentas afterdeliveries and material from curettage specimens after miscarriages, abortions and ectopic preg-nancies were performed.Results: 11 women concieved following successful chemotherapy of gestational trophoblastic dise-ase became pregnant a total 19 times. Out of them there were 9 full-term deliveries, 2 spontaneousabortion, 1 ended in ectopic pregnancy and 7 pregnancies were termined in therapeutic abortion.Cytogenetical analysis was successful in 7 to 10 reproductive losses with normal karyotype in allanalysed cases.Conclusion: Patients after successful chemotherapy of gestational trophoblastic disease havea normal reproductive outcome.

Key words:
gestational trophoblastic disease, choriocarcinoma, pregnancy, chromosomal and DNA

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Paediatric gynaecology Gynaecology and obstetrics Reproduction medicine
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