Membranes V - Epilogue of the Cycle

Authors: J. Mourek 1,2;  J. Pokorný 1;  D. Marešová 1;  I. Paclt 3
Authors‘ workplace: Fyziologický ústav 1. LF UK, Praha ;  přednosta prof. MUDr. O. Kittnar, CSc. Zdravotně-sociální fakulta Jihočeské univerzity, České Budějovice 1;  přednosta prof. MUDr. M. Velemínský, CSc. Psychiatrická klinika l. LF UK a VFN, Praha 2;  přednosta prof. MUDr. J. Raboch, DrSc. 3
Published in: Čes. a slov. Psychiat., 105, 2009, No. 6-8, pp. 269-274.
Category: Comprehensive Reports


Lipoid character of plasma membrane and its hydrophobic properties enable to form delimited spaces, representing the beginning of the intracellular space. Together with the development of organisms and their functions, molecules of fatty acids in the membrane become more and more complex. The rise of complexity is also apparent during ontogeny when the ratio of unsaturated fatty acids OMEGA-3 in plasma of newborns directly correlates with thier birth weight.

Plasma membrane is functionally specialized. It resides in variable expression of individual membrane components in spatially limited regions called domains. Specialized domains of nerve cells determine the function of dendrites, soma, axon, axon hillock act.

In childhood and adolescence a markedly higher plasticity of CNS, variability in oxygen consumption, the yield of aerobic and anaerobic ATP generation, the changeable numbers of ion channels and plasticity of glutamatergic synapses namely in the hippocampus, cerebellum and cerebral cortex can be related to changes in various psychic disorders. Mental diseases in childhood are characteristic by the difficulty to identify by biological methods, including genetic, biochemical and brain imaging techniques.

Structure and organization of plasma membrane domains determines the neuronal plasticity and determine both the optimal function and the potential for a pathogenetic development.

Key words:
lipid bilayer, fatty acids, plasma membrane domains, cell adhesion molecules, matrix-metalloproteinase, hyperkinetic disorder, aggressiveness, depressive disorder, infantile autism.


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Addictology Paediatric psychiatry Psychiatry
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