Amisulpride - a New Benzamide Antipsychotic of the Second Generation
Psychiatrická klinika MU, Fakultní nemocnice, Brno, přednosta prof. MUDr. E. Češková, CSc.
Čes. a slov. Psychiat., , 2000, No. 8, pp. 411-415.
The article reviews data about amisulpride, a new benzamide antipsychotic of the second genera-tion. Amisulpride is pharmacologically characterized by 1. selective high affinity to D2 and D3receptors, 2. higher binding activity to D3 /D2 in the limbic system in relation to striatal receptors,3. double dopamine blockade, e.g. in low doses a preferential blockade of presynaptic D3 /D2 , inhigher doses postsynaptic dopamine receptors. In doses of 50-300 mg it was significantly moresuccessful than placebo in schizophrenics with deficiency syndrome. Positive symptoms impro-ved minimally to the same degree with amisulprid as with haloperidol, flupenthixol and risperi-done. The safety profile of amisulpride is similar to that of risperidone, especially as toextrapyramidal and endocrinological side effects, and better than the safety profile of typicalantipsychotics.
amisulpride, antipsychotics of the second generation, pharmacological profile, defici-ency schizophrenia, side-effects.
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