Influence of the degree of substitution on the absorptivity of acidic carboxymethyl cellulose in the form of nonwoven fabric


Authors: Ruta Masteiková;  Lenka Vinklárková;  Jan Muselík;  David Vetchý;  Jurga Bernatoniene;  Tomáš Sopuch
Authors‘ workplace: Veterinární a farmaceutická univerzita Brno, Farmaceutická fakulta, Ústav technologie léků ;  Katedra technologie léků a sociální farmacie, Farmaceutická fakulta, Akademie medicíny, Litevská univerzita zdravotních věd, Litva ;  Holzbecher spol. s r. o. barevna a bělidlo Zlíč, divize Holzbecher Medical
Published in: Čes. slov. Farm., 2013; 62, 89-94
Category: Original Articles

Overview

Modern wound treatment is based on the creation of moist wound environment which accelerates healing. For these purposes some devices and materials may be used, including carboxymethyl cellulose (CMC). Wound dressings currently available on the market contain CMC in the form of sodium salt. CMC in the acidic form has not been used in wound healing therapy yet. Likewise, there are only a few papers describing the acidic CMC preparation and properties, which are inter alia dependent on the degree of substitution (DS). Therefore, the aim of the study was to evaluate the influence of DS on absorptivity, which is one of the main features of dressings after application on the wound. Samples with DS from 0.1 to 0.45 were examined using five media: purified water, normal saline, buffer solution with pH 7.4, physiological buffer solution with pH 7.2, and solution A. Absorptivity was evaluated using a model wound created by us. It has been found that from the viewpoint of absorptivity the optimal DS of acidic CMC in the form of nonwoven fabric lies in the range from 0.25 to 0.35. Below or above these values the absorptivity is worse.

Keywords:
moist wound healing – carboxymethyl cellulose – degree of substitution – absorptivity


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