Authors: J. Ludvík; J. Prokeš; A. Galatík; J. Fanta Authors‘ workplace: Ústav fyzikální chemie J. Heyrovského Akademie věd ČR, Praha, Ústav toxikologie, 1. lékařské fakulty Univerzity Karlovy, Praha, HYPRO, Otrokovice, Chirurgická klinika Fakultní nemocnice Královské Vinohrady, Praha Published in: Čes. slov. Farm., 2000; , 185-189 Category:
The paper presents an introductory physicochemical study dealing with the preparation of atelocol-lagen felt saturated with local anesthetics, with the modelling of the release of the anesthetic fromthe collagen matrix in vitro, and with the checking of the corresponding analytical procedures(dc-polarography and UV-VIS spectrophotometry) for the determination of cinchocaine. The studyis supplemented with experiments in vivo that confirm the usability of the new material for thedepot formation of local anesthetics.
Key words: atelocollagen – local anesthetics – cinchocaine – depot formation – dc-polarography – UV-VIS spectrophotometry – LD50
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