Anti-Inflammatory Activities of Copper(II) and Zinc(II) p-Cresotates Dihydrates

Czech version

Authors: J. Sokolík; I. Tumová; M. Bláhová; M. Daňková; P. Švec
Authors‘ workplace: Katedra chemickej teórie liečiv a Katedra farmakológie a toxikológie Farmaceutickej fakulty Univerzity Komenského, Bratislava
Published in: Čes. slov. Farm., 2000; , 204-206
Category:

Overview

Using rat paw dextran-induced and carrageenan-induced edemas, the antiedematous activities ofdihydrate of diaquatetrakis(p-cresotato)dicopper(II) complex (CupC) and diaquabis(p-cresotato)zinc(II) complex (ZnpC) were assayed plethysmometrically. Dihydrate of diaquabis(salicyla-to)copper(II) complex (CuS) and diaquabis(salicylato)zinc(II) complex (ZnS) were used as standardsof comparison. All compounds were applied i.p. in a single dose of 50 mmol/kg body weight (calculatedfor the RCOO-fragment) 30 min before injecting the irritant. The antidextran/anticarrageenanactivities of the species (expressed as a mean edema reduction) were found: CupC 46/74 % – ZnpC50/26 % – CuS 71/52 % – ZnS 63/10 %. The relationships between the coordination-chemicalproperties and the biological effects of the corresponding complexes are discussed.

Key words:
copper(II) and zinc(II)p-cresotates – rat paw dextran-induced andcarrageenan-induced edemas – anti-inflammatory activity

Full text is not available online.

If interested in a scan of this journal, contact NTO ČLS JEP.