Authors: J. Dolejšová; R. Karlíček; M. Pospíšilová Authors‘ workplace: Katedra analytické chemie Farmaceutické fakulty Univerzity Karlovy, Hradec Králové Published in: Čes. slov. Farm., 2000; , 199-200 Category:
A flow injection-spectrophotometric determination at 540 nm of hydroxyamphetamine is reported.The procedure is based on a coloured reaction with 2-hydrazono-3-methylbenzothiazole (MBTH)and ceric ammonium nitrate (Ce IV ) as the oxidation reagent. Under optimised conditions, thedetermination of hydroxyamphetamine is achieved in a range of 0.01–0.2 mmol.l -1 with a relativestandard deviation of 0.78 % for 0.05 mmol.l -1 (n=10) and a sample throughput of 75.h -1. The methodwas used for the determination of medicinal drug in the mass-produced dosage form of Czech origin:Pedrolon drops, Galena a.c.
Key words: hydroxyamphetamine – Ce IV – flow injection analysis – spectrophotometricdetermination – drops
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