Evaluation of the Quality of Mexiletine Hydrochloride by Means of CapillaryElectrophoresis

Czech version

Authors: B. Proksa; A. Proksová
Authors‘ workplace: Slovakofarma, a. s., Hlohovec
Published in: Čes. slov. Farm., 2000; , 195-198
Category:

Overview

Mexiletine hydrochloride and its potential impurity xylenol were determined by micelar electrokinetic chromatography in a 25 cm long capillary. The effect of parameters – temperature, electricfield, concentration of analyzed compounds, type and composition of background electrolyte – on theseparation of analytes and precision of analysis was studied. The advantage of the elaboratedmethod is a very short time of analysis (2.3 min) at the sufficient level of precision and reliabilityof results.

Key words:
mexiletine hydrochloride – xylenol – separation – determination – micelarelectrokinetic chromatography.

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