Anti‑N ‑⁠ Methyl ‑⁠ D ‑⁠ Aspartate Receptor Encephalitis

Czech version

Authors: Z. Libá ¹; J. Hanzalová ²; V. Sebroňová ¹; V. Komárek ¹
Authors‘ workplace: 2. LF UK a FN v Motole, Praha Klinika dětské neurologie, Ústav imunologie a neurologická klinika ¹; 2. LF UK a FN v Motole, Praha Likvorová laboratoř, Ústav imunologie a neurologická klinika ²
Published in: Cesk Slov Neurol N 2014; 77/110(5): 624-630
Category: Short Communication
doi: https://doi.org/10.14735/amcsnn2014624

Práce byla podpořena z nadačního fondu Pohyb bez pomoci. Děvana Dimmerová se podílela na zpracování mozkomíšních moků. MU Dr. David Krýsl se společně s RNDr. Jitkou Hanzalovou aktivně podílel na zavedení vyšetření autoprotilátek spojených s encefalitidami do repertoáru likvorové laboratoře ve FN v Motole. MU Dr. Zlata Baraniková se podílela na léčbě psychiatrických příznaků onemocnění. Kolegové z Pediatrické kliniky FN v Motole zajišťovali provedení eliminačních metod.

Overview

N-methyl-D-aspartate encephalitis is a recently defined autoimmune disorder of the central nervous system. Neurological symptoms are associated with antibody-dependent internalization of NMDA receptors that leads to synapse disruption. Information about the disease, therapy and diagnosis are followed by clinical experience with our group of five patients.

Key words:
anti-NMDAR encephalitis –⁠ diagnosis –⁠ therapy

The authors declare they have no potential conflicts of interest concerning drugs, products, or services used in the study.

The Editorial Board declares that the manuscript met the ICMJE “uniform requirements” for biomedical papers.

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