Effect of vitamin K on musculoskeletal health in postmenopausal women

Authors: Rosa Jan 1;  Stančíková Mária 2
Authors‘ workplace: Osteocentrum Affidea Praha, s. r. o. 1;  Národný ústav reumatických chorôb Piešťany 2
Published in: Clinical Osteology 2019; 24(1): 5-13


Vitamin K plays an important role not only in blood clotting, but also in the regulation of mineralization of bones and cartilage. It appears that vitamin K needs for musculoskeletal health are higher than currently recommended daily doses that are optimal for vitamin K1 but suboptimal for vitamin K2. Epidemiological and observational studies have shown that low vitamin K content in the diet and/or serum is associated with the risk of fracture and osteoarthritis in elderly. However, the randomized controlled intervention trials with vitamin K supplementation in Caucasian population are not convincing regarding the increase in bone mineral density at important regions of interest. Combination of vitamin K and D appears to be effective in osteoporosis. Long-term randomized controlled clinical trials with a large number of subjects and well-defined criteria for bone and joint health are required to confirm current observations.


bone – cartilage – osteoarthritis – osteoporosis – vitamin K

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Clinical biochemistry Paediatric gynaecology Paediatric radiology Paediatric rheumatology Endocrinology Gynaecology and obstetrics Internal medicine Orthopaedics General practitioner for adults Radiodiagnostics Rehabilitation Rheumatology Traumatology
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