Hodgkin´s Lymhoma – the Treatment Aproaches Development and Current Trends


Authors: J. Kořen;  M. Trněný
Authors‘ workplace: I. interní klinika –  klinika hematologie 1. LF UK a VFN v Praze
Published in: Klin Onkol 2015; 28(Supplementum 3): 87-94
doi: 10.14735/amko20153S87

Overview

Hodgkin’s lymphoma is a relatively rare malignant disease, mostly affecting younger adults. It represents one of the most curable disease among all lymphomas and other malignant diseases of adult age, with curability more than 80%. The progress of curability and long term survival demonstrates the development of oncologic approach during the last few decades, depicted in this article, particularly by introduction of combined modality treatment (chemotherapy and radiotherapy), progress in radiotherapy technique, implementation of high intensity regimens for advanced stages and use of novel drugs as well. Because of high curability rate and young age of most of the patients, late toxic effects are of significant relevance. The ongoing clinical research is focused on better prognostic stratification offering the patients more individualized treatment by risk and response disease evaluation, aiming to reduce toxicity while maintaining high curability and introduction of novel, less toxic drugs and their use in early phases of treatment.

Key words:
Hodgkin’s lymphoma – induction chemotherapy – salvage therapy – combined modality ther­apy – hematopoietic stem cell transplantation – positron-emission tomography – brentuximab vedotin – nivolumab

This study was supported by grants of Internal Grant Agency of the Czech Ministry of Health No. NT13072-4/2012 and NT12193-5/2011.

The authors declare they have no potential conflicts of interest concerning drugs, products, or services used in the study.

The Editorial Board declares that the manuscript met the ICMJE recommendation for biomedical papers.

Submitted:
27. 9. 2015

Accepted:
1. 10. 2015


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