The Possibility of Epidermal Growth Factor Receptor Inhibition in Anal Cancer
Authors:
I. Richter 1; J. Dvořák 2; T. Jirásek 3; J. Bartoš 1
Authors‘ workplace:
Onkologické oddělení, Krajská nemocnice Liberec, a. s.
1; Onkologická klinika 1. LF UK a Thomayerova nemocnice, Praha
2; Oddělení patologie, Krajská nemocnice Liberec, a. s.
3
Published in:
Klin Onkol 2015; 28(4): 260-264
Category:
Review
doi:
https://doi.org/10.14735/amko2015260
Overview
Anal cancer is a relatively rare tumour. In local and locally advanced disease, concomitant chemoradiation based on mitomycin C and 5-fluorouracil, remains golden standard of treatment. However, this treatment is associated with significant morbidity. With the developing of molecular biology, new treatment strategies can be investigated. Epidermal growth factor receptor (EGFR) expression in anal cancer is observed in 55–100% of cases. Some studies demonstrated that KRAS mutations, mechanism marker of resistance to antiEGFR therapy, are rare in anal cancer. This paper presents current view on the possibilities of antiEGFR therapy in locally advanced and metastatic anal cancer.
Key words:
anal cancer – chemoradiotherapy – monoclonal antibodies – epidermal growth factor receptor
The authors declare they have no potential conflicts of interest concerning drugs, products, or services used in the study.
The Editorial Board declares that the manuscript met the ICMJE “uniform requirements” for biomedical papers.
Submitted:
29. 3. 2015
Accepted:
29. 4. 2015
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Paediatric clinical oncology Surgery Clinical oncologyArticle was published in
Clinical Oncology
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