Compatibility index: does this apply to patients following a heart transplant?


Authors: H. Bedáňová;  J. Ondrášek;  J. Černý;  P. Němec
Published in: Kardiol Rev Int Med 2011, 13(1): 48-51
Category: From Heart Failure to Heart Transplantation

Overview

Based on the Compatibility Index, routinely used in renal transplants, we attempted to identify those patients who had just had a heart transplant for whom a number of agreements in the HLA system meant that they could be receptive to lower doses of immunosuppressants. We carried out a retrospective analysis of 182 consecutive patients who had received transplants in the Centre of Cardiovascular and Transplantation Surgery in Brno from January 2001 to April 2010. According to their Compatibility Index, patients were arbitrarily divided into Group A (83 patients) with Compatibility Index 0–17 and Group B (99 patients) with Compatibility Index 18–26. We recorded a significantly lower incidence of step 2 acute cellular rejection in group A (p ≤ 0,05), with the incidence of level 3 being the same in both groups. There were no significant diffe­rences in rates of infections, nor in the malignancy rate, which was relatively low. Long-term survival was similar in both groups, with a tendency to better progress in Group A in the period from the 2nd–5th years following the transplant.

Keywords:
compatibility index – heart transplant – acute cellular rejection – infections – tumours


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Labels
Paediatric cardiology Internal medicine Cardiac surgery Cardiology
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