Authors: D. Mach Authors‘ workplace: ARO, NIP & Urgentní příjem, Nemocnice Nové Město na Moravě, p. o. Published in: Anest. intenziv. Med., 31, 2020, č. Supplementum A, s. 14-16
Desflurane is a halogenated inhalation general anaesthetic agent with low solubility in blood and body tissues, and approximately one-fifih the potency of isoflurane. The low solubility of desflurane facilitates a rapid induction of anaesthesia and precise control of the depth of anaesthesia. Transient airway irritant effects are the most common adverse events during induction of anaesthesia with desflurane; therefore, this agent is not recommended for induction of anaesthesia in paediatric patients. Overall it embodies many of the desirable features of an ideal agent, which include stability to chemical degradation, low solubility in blood and body tissues, negligible metabolism and low potential for hepatorenal toxicity. These favourable physical and pharmacokinetic characteristics should present desflurane as a valuable inhalation anaesthetic agent for the maintenance of general anaesthesia in ambulatory surgery as well as in nonambulatory surgical procedures.
inhalation anaesthetics – desflurane
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