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Consensus on the Administration of TPO-RA as Second-Line Therapy in ITP

10. 8. 2022 Source: Immune Thrombocytopenia

What is the role of thrombopoietin receptor agonists (TPO-RA) in the second line treatment of patients with immune thrombocytopenia (ITP)? Italian authors conducted a survey using the Delphi method among selected experts to gather answers to this question and recommendations for clinical practice. Here, we briefly summarize the key points of their consensus published last year.

Brentuximab vedotin in combination with lenalidomide and rituximab in R/R DLBCL –⁠ results from the open part of the ECHELON-3 study

The aim of the open run-in phase of the randomized placebo-controlled phase III ECHELON-3 study, the results of which were presented at the ASCO and EHA 2022 congresses, was to evaluate the efficacy…

10. 8. 2022 Source: Hematologic Malignancies

pacient s klasickým Hodgkinovým lymfomem

6-year data from the ECHELON-1 study: How does combining brentuximab vedotin with chemotherapy affect overall survival of previously untreated cHL patients?

At this year's annual congress of the European Hematology Association (EHA), results from the analysis of 6-year data from the international randomized open-label phase III ECHELON-1 study on overall…

10. 8. 2022 Source: Hematologic Malignancies

How to Save a Leg from Amputation?

Feared complications in diabetics include defects in typical locations on the lower limbs. Their presence and frequent recurrences increase the risk of possible amputation of varying degrees, mainly…

10. 8. 2022 Source: Wound Healing

Prophylaxis EHL products FVIII bring improvements in clinical and pharmacokinetic results

A freshly published real-world clinical practice study from Spain highlights the experience of switching patients with hemophilia A in a prophylaxis setting from standard half-life products to newer…

8. 8. 2022 Source: Hemophilia

Emotional joyful patient telling his doctor good news

Benefit of Adding Empagliflozin to Standard Therapy in Heart Failure with Reduced Ejection Fraction

The use of empagliflozin led to a reduction in the risk of hospitalization for heart failure or death from cardiovascular (CV) causes in the EMPEROR-Reduced study in patients with adequately treated…

5. 8. 2022 Source: Heart Failure

Sequential administration of immunochemotherapy and venetoclax after failure of BCR inhibitor treatment –⁠ interactive video case study

The treatment of chronic lymphocytic leukemia (CLL) is evolving. What was impossible years ago is now becoming a reality. From chemotherapy, through immunochemotherapy, to the use of molecules…

5. 8. 2022 Source: Chronic Lymphocytic Leukemia

Hydroresponsive Dressings for Acute and Hard-to-Heal Wounds

A recently published review of clinical evidence from nearly three dozen studies demonstrates successful debridement and cleansing of various hard-to-heal wounds using HydroClean hydroresponsive…

4. 8. 2022 Source: Wound Healing

Prediabetes through the lens of current data and findings −⁠ and why hurry with intervention

Type 2 diabetes mellitus (DM2) is one of the most common causes of premature morbidity and mortality worldwide. The most serious impact on the health of the organism is mainly due to the…

27. 7. 2022 Source: Diabetes

Discontinuation of Methotrexate After Initiation of Tofacitinib in the Treatment of Rheumatoid Arthritis

New real-world data show that in patients with rheumatoid arthritis (RA) who started treatment with tofacitinib combined with oral methotrexate (MTX), it is possible to discontinue MTX and achieve…

27. 7. 2022 Source: Arthritis

Incidence of CV Events, Malignancies, and Venous Thromboembolism in Patients with RA According to Baseline CV Risk and Administered Treatment

An international team of experts evaluated the impact of cardiovascular (CV) risk on the incidence and risk of major CV events, malignancies, and venous thromboembolism (VTE) in patients with…

27. 7. 2022 Source: Arthritis

Increase in Hematocrit During Empagliflozin Treatment in a Diabetic Patient with Severe Anemia −⁠ A Case Study

In a case study involving a 78-year-old diabetic patient, where only the administration of empagliflozin led to the correction of severe anemia of unknown origin, Polish authors demonstrate the…

26. 7. 2022 Source: Heart Failure

Composition of the Intestinal Microbiota of Patients with IBS May Predetermine the Success of a Diet with Low Fermentable Carbohydrates

Some patients with irritable bowel syndrome may benefit from a diet low in fermentable carbohydrates, but the mechanism of this intervention is not yet satisfactorily explained. A study published in …

23. 7. 2022 Source: Irritable Bowel Syndrome

Can the use of sartans reduce mortality and severity of COVID-19 in hypertensives?

Existing scientific and clinical evidence suggests the involvement of the renin-angiotensin-aldosterone system (RAAS) in the pathophysiology of COVID-19. Some of the initial experimental therapy…

21. 7. 2022 Source: Sartans in the Treatment of Hypertension

Diagnosis of Skin Malignancies via Mobile Application Successfully Tested in the UK

Skin malignancies are a significant global cause of morbidity and mortality, with melanoma responsible for most deaths, and its incidence is increasing faster than any other cancer. Early detection…

21. 7. 2022 Source: proLékaře.cz

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