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Critical Overview of Clinical Studies on EHL FVIII Preparations

1. 2. 2023 Source: Hemophilia

An international team of experts recently published a comprehensive work evaluating the methodology used in clinical trials of various extended half-life (EHL) factor VIII (FVIII) products. Their work does not directly compare the individual products but aims to assess the results of key registration clinical trials from the perspective of the hematologist and everyday clinical practice.

Overview of Regimen Measures for House Dust Mite Allergy

House dust mite allergy is one of the significant causes of respiratory allergies in both children and adult patients. In addition to pharmacological treatment, the cornerstone of therapy also…

31. 1. 2023 Source: Dust Mite Allergy

Long-term Safety of Dupilumab in Adult Patients with Moderate to Severe Atopic Dermatitis

Moderate to severe atopic dermatitis (AD) often requires systemic therapy. The long-term safety of dupilumab in patients with this condition was evaluated in an open-label extension (OLE) of the…

24. 1. 2023 Source: Systemic treatment of atopic dermatitis, asthma, and chronic rhinosinusitis with nasal polyposis – Type 2 inflammation

Treatment of Tumors Using Ultrasound? The First Results of the Use of Histotripsy Look Promising

Histotripsy represents a new therapeutic method that allows the non-invasive removal of tumor tissue using the principle of so-called ultrasound cavitation. The method has been successfully tested in…

24. 1. 2023 Source: proLékaře.cz

Tiapride versus Haloperidol in the Therapy of Aggressiveness and Agitation in Elderly Patients with Cognitive Impairment

Acute restlessness, agitation, and aggression can be associated with psychiatric disorders but also be manifestations of somatic illnesses. Psychomotor agitation combined with disorientation is…

19. 1. 2023 Source: Viral infections

Non-Invasive Diagnosis of Cardiac Amyloidosis

Cardiac amyloidosis has always been considered a rare pathology. However, thanks to advancements in imaging methods and laboratory tests, it is now evident that it might be responsible for a larger…

16. 1. 2023 Source: Amyloidosis

Memantine, Acetylcholinesterase Inhibitors, and Their Combination in the Treatment of Alzheimer's Disease −⁠ Findings from Meta-Analyses

Is memantine, an acetylcholinesterase inhibitor (donepezil), or their combination more advantageous in the therapy of Alzheimer's disease? Two meta-analyses tried to answer this question, and we…

12. 1. 2023 Source: Cognitive in the treatment of Alzheimer's disease

Long-term Efficacy, Safety, and Tolerability of Normal Human IgG with Facilitated Absorption in Patients with Humoral Immunodeficiency

The treatment of patients with humoral immunodeficiency is long-term and therefore needs to be not only effective but also safe and well-tolerated. Below, we present the outcomes from an Italian…

12. 1. 2023 Source: Primary and Secondary Immunodeficiencies

fSCIG in Elderly Patients with PID or SID in Real Clinical Practice

The work of a team of German and Dutch authors presents data on the real clinical use of 10% subcutaneous immunoglobulin facilitated by hyaluronidase (fSCIG) in elderly patients with primary (PID) or…

12. 1. 2023 Source: Primary and Secondary Immunodeficiencies

Current NCCN Recommendations for Classification and Risk Symptoms in SLL/CLL

The new recommendations from the National Comprehensive Cancer Network (NCCN) regarding chronic lymphocytic leukemia (CLL) and small lymphocytic lymphoma (SLL) from August 2022 also include a brief…

12. 1. 2023 Source: Chronic Lymphocytic Leukemia

Electronic Cigarettes as an Alternative Option for Quitting Smoking?

Diseases caused by smoking tobacco products are a significant cause of global morbidity and mortality. One of the options for quitting smoking is electronic cigarettes, which, although not entirely…

12. 1. 2023 Source: MDT Board

Diabetes mellitus and heart failure −⁠ interconnected units with complex pathogenesis

Diabetes mellitus (DM) represents a significant risk factor for the development of heart failure. The pathogenesis of this condition is very complex, involving hyperglycemia and other metabolic…

12. 1. 2023 Source: Heart Failure

Teriflunomide "under the microscope" or what it's like to live with MS in the North

The Teri-LIFE study examined teriflunomide very comprehensively. How does it manage to affect the quality of life of patients with multiple sclerosis (MS) according to data from real clinical…

12. 1. 2023 Source: Multiple Sclerosis

Cardiovascular Interventions with Continued Therapy with Dabigatran −⁠ Insights from the GLORIA-AF Study

An analysis using data from an international registry of patients with newly diagnosed atrial fibrillation evaluated the safety and efficacy of continued therapy with dabigatran during cardioversion…

12. 1. 2023 Source: Anticoagulant Treatment

Smouldering Multiple Sclerosis: How Can MRI Help in Its Identification?

With the changing understanding of the etiopathogenesis of multiple sclerosis, several new questions arise. One of them is the question of identifying the progressive phase of the disease. Can…

4. 1. 2023 Source: Multiple Sclerosis

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