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What to add to amlodipine when it alone is not enough for hypertension?

18. 3. 2024 Source: Cardiovascular Continuum

Treating hypertension is a daily task for not only general practitioners and cardiologists. Polish doctors evaluated the effect of adding bisoprolol on the blood pressure of patients with inadequately controlled hypertension on amlodipine monotherapy in a placebo-controlled AMCOR study.

Effect of Extended-Release Metformin on Cognitive Functions in Older Frail Women with Diabetes and Hypertension

Women have a higher risk of geriatric frailty regardless of age and menopausal status. This risk further increases with the presence of diabetes and hypertension, which also elevate the risk of…

14. 3. 2024 Source: Cardiovascular Risks

ACC 2023 Expert Consensus: How to Optimize Diagnosis and Treatment of Heart Failure with Preserved EF LK

Heart failure (HF) remains a significant cause of morbidity and mortality, with the incidence and prevalence of HF with preserved left ventricular ejection fraction (HFpEF) rising. The following…

14. 3. 2024 Source: Heart Failure

Causes, Consequences, and Solutions to Weight Gain in Schizophrenia Treatment

The use of antipsychotics in the treatment of schizophrenia is often associated with the development of overweight and obesity, which poses a risk for the onset of many diseases and increases…

13. 3. 2024 Source: Modern Treatment of Schizophrenia

Current findings on the treatment of gestational diabetes and DM2 in pregnancy with metformin

Recent reviews have shown that metformin is a safe alternative to insulin in the treatment of diabetes during pregnancy. For gestational diabetes (GDM) and type 2 diabetes mellitus (DM2), metformin…

12. 3. 2024 Source: Modern Treatment of Diabetes

Trastuzumab Deruxtecan in Patients with HER2+ Metastatic Breast Cancer

Last year, results of studies published in the Lancet journal demonstrated a significant clinical benefit of trastuzumab deruxtecan in patients with HER2⁺ metastatic breast cancer (mBC) pre-treated…

12. 3. 2024 Source: Ovarian and Breast Cancer

Benefits of Time-Limited CLL Therapy

The advent of new targeted molecules has significantly influenced the possibilities of therapy for chronic lymphocytic leukemia (CLL) and are now an integral part of treatment regimens, including the…

5. 3. 2024 Source: Chronic Lymphocytic Leukemia

Improving treatment outcomes of HF with preserved ejection fraction according to JACC: What does the success of gliflozins mean for the future?

The Journal of the American College of Cardiology (JACC) recently issued a scientific statement in which the authors thoroughly examined current knowledge on the epidemiology, pathophysiology,…

4. 3. 2024 Source: Heart Failure

Current Reimbursement Conditions for the Dual Inhibitor IL-4/IL-13 Dupilumab

The biologic dupilumab is approved for the treatment of several diseases with type 2 inflammation. What is the current reimbursement situation in key indications? We summarize in the following brief…

4. 3. 2024 Source: Systemic treatment of atopic dermatitis, asthma, and chronic rhinosinusitis with nasal polyposis – Type 2 inflammation

Digital Bridge Between the Brain and Spine: How an Implant Restored Walking Ability to a Paralyzed Patient −⁠ Case Study

When a spinal cord injury occurs, communication between the brain and peripheral nerves is interrupted, causing paralysis. Until recently, it was not possible to restore mobility for most of these…

4. 3. 2024 Source: proLékaře.cz

A Cloned Monkey Survived to Adulthood for the First Time. Will We Soon Be Able to Clone Humans?

A macaque named ReTro, born as a result of a cloning experiment by Chinese scientists, has reached adulthood. This is the first such successful cloning that could pave the way for further primate…

4. 3. 2024 Source: proLékaře.cz

Can we properly manage osteoporotic fractures?

Osteoporotic fractures are associated with increased morbidity and mortality and often lead to an overall deterioration in the quality of life. We should not forget to diagnose osteoporosis in…

29. 2. 2024 Source: Osteoporosis – Trends in Sequential Therapy

Meta-analysis of the Effectiveness of Romosozumab in the Treatment of Postmenopausal Osteoporosis

Osteoporosis is a prevalent disease with unmet therapeutic needs. Whether the anti-sclerostin antibody romosozumab can offer an effective improvement in osteoporosis treatment outcomes in…

29. 2. 2024 Source: Osteoporosis – Trends in Sequential Therapy

Lurasidone in a Patient with Paranoid Schizophrenia and Asperger's Syndrome –⁠ A Case Study

Lurasidone is an effective and very gentle antipsychotic which is establishing a prominent position in modern psychopharmacotherapy. Its unique receptor profile makes it a suitable choice for…

27. 2. 2024 Source: Modern Treatment of Schizophrenia

Clinical Significance of Smaller Gaps Between Strengths of Levothyroxine Preparations in the Treatment of Hypothyroidism

Many levothyroxine preparations have relatively large intervals between doses (25 µg, 50 µg, and 75 µg), creating obstacles for some patients to achieve an optimal maintenance dose. The availability…

23. 2. 2024 Source: Thyroid Disorders

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