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Trastuzumab Deruxtecan in Patients with HER2+ Metastatic Breast Cancer

12. 3. 2024 Source: Ovarian and Breast Cancer

Last year, results of studies published in the Lancet journal demonstrated a significant clinical benefit of trastuzumab deruxtecan in patients with HER2⁺ metastatic breast cancer (mBC) pre-treated with anti-HER2 therapy, in the 2nd or later lines of treatment compared to trastuzumab emtansine (DESTINY-Breast03 study, second interim overall survival analysis) and after failure of trastuzumab emtansine compared to physician's choice of therapy (DESTINY-Breast02 study).

Benefits of Time-Limited CLL Therapy

The advent of new targeted molecules has significantly influenced the possibilities of therapy for chronic lymphocytic leukemia (CLL) and are now an integral part of treatment regimens, including the…

5. 3. 2024 Source: Chronic Lymphocytic Leukemia

Improving treatment outcomes of HF with preserved ejection fraction according to JACC: What does the success of gliflozins mean for the future?

The Journal of the American College of Cardiology (JACC) recently issued a scientific statement in which the authors thoroughly examined current knowledge on the epidemiology, pathophysiology,…

4. 3. 2024 Source: Heart Failure

Current Reimbursement Conditions for the Dual Inhibitor IL-4/IL-13 Dupilumab

The biologic dupilumab is approved for the treatment of several diseases with type 2 inflammation. What is the current reimbursement situation in key indications? We summarize in the following brief…

4. 3. 2024 Source: Systemic treatment of atopic dermatitis, asthma, and chronic rhinosinusitis with nasal polyposis – Type 2 inflammation

Digital Bridge Between the Brain and Spine: How an Implant Restored Walking Ability to a Paralyzed Patient −⁠ Case Study

When a spinal cord injury occurs, communication between the brain and peripheral nerves is interrupted, causing paralysis. Until recently, it was not possible to restore mobility for most of these…

4. 3. 2024 Source: proLékaře.cz

A Cloned Monkey Survived to Adulthood for the First Time. Will We Soon Be Able to Clone Humans?

A macaque named ReTro, born as a result of a cloning experiment by Chinese scientists, has reached adulthood. This is the first such successful cloning that could pave the way for further primate…

4. 3. 2024 Source: proLékaře.cz

Can we properly manage osteoporotic fractures?

Osteoporotic fractures are associated with increased morbidity and mortality and often lead to an overall deterioration in the quality of life. We should not forget to diagnose osteoporosis in…

29. 2. 2024 Source: Osteoporosis – Trends in Sequential Therapy

Meta-analysis of the Effectiveness of Romosozumab in the Treatment of Postmenopausal Osteoporosis

Osteoporosis is a prevalent disease with unmet therapeutic needs. Whether the anti-sclerostin antibody romosozumab can offer an effective improvement in osteoporosis treatment outcomes in…

29. 2. 2024 Source: Osteoporosis – Trends in Sequential Therapy

Lurasidone in a Patient with Paranoid Schizophrenia and Asperger's Syndrome –⁠ A Case Study

Lurasidone is an effective and very gentle antipsychotic which is establishing a prominent position in modern psychopharmacotherapy. Its unique receptor profile makes it a suitable choice for…

27. 2. 2024 Source: Modern Treatment of Schizophrenia

Clinical Significance of Smaller Gaps Between Strengths of Levothyroxine Preparations in the Treatment of Hypothyroidism

Many levothyroxine preparations have relatively large intervals between doses (25 µg, 50 µg, and 75 µg), creating obstacles for some patients to achieve an optimal maintenance dose. The availability…

23. 2. 2024 Source: Thyroid Disorders

Generic Substitution of Levothyroxine in Practice

The active ingredient levothyroxine is found in a significant number of medicinal products (MP) in the Czech Republic. The question of its generic substitution remains current, primarily because the…

22. 2. 2024 Source: Thyroid Disorders

Options for Systemic Therapy of Advanced Stage Small Cell Lung Cancer

Small cell lung cancer (SCLC) is the most aggressive type of lung tumor. Although it responds well to chemotherapy and radiotherapy, due to the early onset of treatment resistance, the 5-year…

22. 2. 2024 Source: Small Cell Lung Cancer

Current Sequence of Treatment for Metastatic HER2+ Breast Cancer

In September 2023, experts from Miami Cancer Institute published their consensus statement on the treatment of HER2-positive advanced breast cancer (BC). The latest change in therapeutic strategy is…

22. 2. 2024 Source: Ovarian and Breast Cancer

Artificial Intelligence and Deep Learning as the Future of Glaucoma Diagnosis

Glaucoma represents a group of eye diseases characterized by changes to the optic nerve. It is the second most common cause of blindness, currently affecting more than 90 million people worldwide. It…

21. 2. 2024 Source: proLékaře.cz

MUDr. Jana Zárubová: Experiences with buccal midazolam in real practice are positive and we can significantly improve patients' quality of life

Recently, it has emerged as an alternative to traditionally rectally administered diazepam for stopping prolonged convulsive seizures in patients with epilepsy. What can buccal midazolam offer them…

21. 2. 2024 Source: Quick aid for acute convulsive seizures in children and adolescents

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