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ESMO Recommendations for the Treatment of Low-Risk Myelodysplastic Syndrome
6. 9. 2023 Source: proLékaře.czThe priority in the treatment of low-risk myelodysplastic syndrome (MDS) is managing cytopenia, primarily anemia, as well as neutropenia and thrombocytopenia. The following summary of recommendations sets the criteria for response to treatment and lists current therapeutic options for the 1st and 2nd lines.
Effect of Luspatercept Treatment in Patients with MDS/MPN-RS-T
The presented post hoc analysis of the MEDALIST study demonstrates the effect and good tolerance of luspatercept in the rare disease from the myelodysplasia group − MDS/MPN-RS-T.6. 9. 2023 Source: proLékaře.cz
Association between Hypothyroidism, Depression, and Anxiety Disorder – Results of Meta-Analyses
The prevalence of autoimmune thyroiditis in the USA ranges between 4 and 13%. Subclinical hypothyroidism affects 3–8.5% of the general population. Patients with this condition are at risk not only…6. 9. 2023 Source: Thyroid Disorders
A Look at Tongue and Its Care from the Perspective of Western and Traditional Chinese Medicine
The tongue is a valuable diagnostic tool used in both Traditional Chinese Medicine (TCM) and Western medicine. While the approaches to tongue care between these two medical systems differ…6. 9. 2023 Source: Dental Care
Management of Adverse Effects During Maintenance Treatment of AML Patients
The randomized phase III study QUAZAR AML-001 evaluated the maintenance treatment of acute myeloid leukemia (AML) in patients after first remission. The following text summarizes the findings…4. 9. 2023 Source: Acute Myeloid Leukemia
SCOPE 2021 – State of Osteoporosis and Its Treatment in European Countries
The SCOPE 2021 project (The Scorecard for Osteoporosis in Europe) by the International Osteoporosis Foundation (IOF) gathered and tabulated data from 29 European countries on the burden of…4. 9. 2023 Source: Osteoporosis – Trends in Sequential Therapy
Risk of Subsequent Fractures in Postmenopausal Women After Initial Fracture
Osteoporosis is associated with an increased risk of fractures. The prospective analysis presented below examined the risk of subsequent fractures in postmenopausal women after an initial fracture…4. 9. 2023 Source: Osteoporosis – Trends in Sequential Therapy
Laboratory Safety of Dupilumab Treatment in Children with Atopic Dermatitis Aged 6 Months to 6 Years
Previous clinical studies in children aged 6–12 years with moderate-to-severe atopic dermatitis have demonstrated laboratory safety during dupilumab treatment. The randomized study presented below…
Long-term Safety and Efficacy of Ozanimod in the Treatment of Relapsing Forms of MS
Ozanimod is classified as a modulator of sphingosine-1-phosphate (S1P) receptors types 1 and 5. It is approved for the treatment of relapsing-remitting multiple sclerosis (RRMS) and moderate to…28. 8. 2023 Source: Modulation of S1P in the Treatment of Autoimmune Diseases
How does empagliflozin perform in older type 2 diabetics compared to liraglutide and sitagliptin in terms of HHF and MACE risks?
Last fall, a study was published in JAMA Network Open, focusing on older patients with type 2 diabetes mellitus (DM2), examining the cardiovascular risk impact when treated with empagliflozin,…28. 8. 2023 Source: Diabetes
Prof. Roman Chlíbek: Role of Multivalent Pneumococcal Conjugate Vaccines in Healthy and Premature Children
Children are frequent carriers of pneumococci, which can cause both common non-invasive and more severe, life-threatening invasive pneumococcal diseases, especially in children under 1 year of age…25. 8. 2023 Source: Regular Vaccination
Efficacy of Empagliflozin in HFpEF Patients – Comparison of Subpopulations with Preserved and Mid-Range LV EF
A sub-analysis of the EMPEROR-Preserved clinical trial examined the effects and safety of empagliflozin in patients with heart failure with a left ventricular ejection fraction (LV EF) > 40%. What…24. 8. 2023 Source: Heart Failure
EULAR 2023: How does tofacitinib affect cardiovascular risk in rheumatoid arthritis?
At this year's European League Against Rheumatism (EULAR) congress, held at the turn of May and June in Milan, Italy, a study was presented that examined the impact of tofacitinib use on…23. 8. 2023 Source: Arthritis
Efficacy of Ceftazidime/Avibactam in the Treatment of Infections Caused by Carbapenemase-Producing Enterobacteria
Infections caused by carbapenemase-producing enterobacteria are associated with high mortality, and their incidence continues to rise. The study presented below investigated the efficacy of therapy…22. 8. 2023 Source: Anti-Infectives
EULAR 2023: What Do CRP Levels Reveal About the Efficacy and Safety of Tofacitinib in Patients with Ankylosing Spondylitis?
What is the impact of baseline C-reactive protein (CRP) levels on the efficacy and safety of treating ankylosing spondylitis (AS) with the Janus kinase inhibitor (JAKi) tofacitinib? The authors of…22. 8. 2023 Source: Arthritis
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