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News Efficacy and Safety of Etanercept in the Therapy of Arthritis
A review by experts from Genoa, Italy, focused on the available knowledge regarding the efficacy and safety of etanercept in the treatment of inflammatory rheumatic diseases.
News Eletriptan and Its Role in Acute Migraine Therapy
In the acute treatment of moderate to severe migraine attacks, medications from the triptan group are primarily used. The following article summarizes important findings about eletriptan and its key results in clinical studies.
News Experience from Clinical Practice with Intestinal Gel LECIG in Treating Parkinson's Disease
A Swedish observational study evaluated the applicability of the LECIG intestinal gel, which contains levodopa (20 mg/ml), carbidopa (5 mg/ml), and entacapone (20 mg/ml), in clinical practice for patients with Parkinson's disease.
News Discontinuation of Methotrexate After Initiation of Tofacitinib in the Treatment of Rheumatoid Arthritis
New real-world data show that in patients with rheumatoid arthritis (RA) who started treatment with tofacitinib combined with oral methotrexate (MTX), it is possible to discontinue MTX and achieve the same treatment results as with its continued use, additionally at lower costs.
News Sequential administration of immunochemotherapy and venetoclax after failure of BCR inhibitor treatment – interactive video case study
The treatment of chronic lymphocytic leukemia (CLL) is evolving. What was impossible years ago is now becoming a reality. From chemotherapy, through immunochemotherapy, to the use of molecules targeting apoptotic pathways of tumor cells, the prognosis for patients has markedly improved. However, the wide therapeutic spectrum also brings its own specifics and complications, and the correct sequencing of treatment lines and their selection for each individual is necessary, considering the nature of CLL, overall condition, and comorbidities.
News Ceftaroline as a Treatment Option for MRSA-Induced Sepsis?
A recently published study by a team of authors from several American institutions focused on comparing the efficacy and safety of the 5th generation cephalosporin ceftaroline with the standard of care in the treatment of sepsis caused by methicillin-resistant Staphylococcus aureus (MRSA).
News Modification of Criteria for Diagnosing Irritable Bowel Syndrome in Clinical Practice
The Rome criteria for diagnosing disorders of gut-brain interaction (DGBI) have recently been modified due to discrepancies with their use in clinical practice. The Rome Foundation board has created modified Rome IV diagnostic criteria. When caring for patients with DGBI, including irritable bowel syndrome (IBS), it will be possible to diagnose even with shorter duration and lower frequency of symptoms.
News Frequency of Participation in Sports Activities and the Risk of Injury in Children with Hemophilia
In children with hemophilia, numerous positive effects of physical activity on their health have been described. However, due to concerns about injuries and joint bleeding, young hemophiliacs may often be limited in real participation in sports life. Results from published studies, however, indicate that with proper therapy, the frequency of injuries is similar to that of the general population.
News Bacterial Community Pneumonia and Its Treatment in Children
Bacterial infections remain a significant cause of child morbidity and mortality. The authors of a recent review published in the journal Pediatric Drugs focused on the treatment of complicated infections in the pediatric population. Here we bring a brief summary concerning community-acquired pneumonia.
News Overall Survival in Patients with Metastatic CRC During 1st-Line Anti-EGFR Treatment Depending on the Presence or Absence of Hypomagnesemia
Hypomagnesemia is one of the side effects of monoclonal antibody therapy against the epidermal growth factor receptor (EGFR). The study presented below examined overall survival in patients with metastatic primarily unresectable colorectal cancer (CRC) treated with anti-EGFR therapy depending on the presence or absence of hypomagnesemia.
News Options for Prevention and Treatment of Infantile Colic – A Systematic Review of Studies
The authors of the cited literature review evaluated evidence of the benefits of various preventive and therapeutic options for infantile colic. Administering probiotics appears to be a promising therapeutic strategy.
News Impact of ACEi and ARBs on Lung Function in Patients with Hypertension
Worsening respiratory functions can significantly influence the choice of antihypertensive medication. A recently published study explored whether angiotensin-converting enzyme inhibitors (ACEi) can worsen lung function and whether this effect also appears with angiotensin II receptor blockers (ARBs, i.e., sartans). These findings are crucial for clinical practice, especially in treating patients at high risk for respiratory adverse effects.
News ITP with Severe Hemorrhagic Manifestations Associated with COVID-19 – Case Study
There can be numerous causes of newly acquired immune thrombocytopenia (ITP), often being idiopathic. Severe COVID-19 can be associated with ITP manifestations where the standard first-line treatment may not be effective. In life-threatening bleeding situations, adding romiplostim has proven effective, as illustrated by the following case study from authors in Montreal, Canada.
News Development of Immune Thrombocytopenia as a Result of Past COVID-19 Illness
Immune thrombocytopenia (ITP) developing secondary to COVID-19 is a completely new experience in clinical practice. A brief summary on this topic, describing incidence and response to treatment, was published last year by authors from Cleveland.
News Analgesic Effect of Metamizole in Cold-induced Pain
The cold test is used to experimentally induce acute pain – it can thus be used, for example, to test the efficacy of analgesics. The authors of a recently published German study evaluated the analgesic effect and tolerability of metamizole compared to opioid analgesics using this method. They were led by the fact that although the drug has proven clinical efficacy and safety, it has not yet been tested using this procedure, unlike opioids.