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News Options for Systemic Therapy of Advanced Stage Small Cell Lung Cancer
Small cell lung cancer (SCLC) is the most aggressive type of lung tumor. Although it responds well to chemotherapy and radiotherapy, due to the early onset of treatment resistance, the 5-year survival rate is less than 10%. After more than 30 years of very limited progress in treating advanced SCLC patients, immune checkpoint inhibitors (checkpoints) have been introduced to the market, significantly prolonging survival. What are the current recommendations for treating patients with advanced SCLC?
News Kadcyla in a New Indication – Adjuvant Therapy for Early HER2+ Breast Cancer
In December, the European Commission approved the expansion of the indication for Roche's medicinal product Kadcyla, which contains the active substance trastuzumab emtansine. This expansion makes adjuvant treatment accessible to a much larger number of patients with early HER2-positive breast cancer and reduces the likelihood of disease recurrence or progression.
News Revolutionary Change in the Paradigm of Multiple Sclerosis (MS) Treatment in the Czech Republic
At the beginning of last year, there was a revolutionary change in the paradigm of multiple sclerosis (MS) treatment in the Czech Republic. Patients with MS and an unfavorable prognosis no longer have to go through ineffective medications on their way to highly effective therapy (HET, High Efficacy Therapy), but can be treated with the highly effective drug Ocrevus® from the first symptoms of the disease.
News According to which parameters can we best assess the quality of incontinence aids?
Properly chosen incontinence aid significantly influences the user's quality of life. When selecting incontinence aids, it is very important to consider their individual properties and parameters. While in European countries the absorbency of the aid is mainly assessed alongside the product's size and the user's gender, other parameters are evaluated elsewhere in the world. So what should we primarily focus on when choosing an aid?
News New Solution for Moderate Incontinence – Discreet Pull-Up Diaper Pants
The range of products for people with incontinence is constantly expanding – recent additions include pull-up diaper pants labeled Seni Active Basic and Seni Active Classic.
News Care of Surgical Wounds and Choice of Dressings − Main Findings of the Latest International Expert Consensus
In December 2022, Wounds International published a summary of consensus outputs from six international expert meetings dedicated to postoperative care of surgical wounds and the selection of their dressings.
News How to Reduce the Risk of Venous Thromboembolism in Users of Combined Hormonal Contraceptives?
The use of combined oral contraceptives (COCs) is a known risk factor for thromboembolism. Therefore, we should consider the individual risk of each patient before prescribing COCs. Women with a positive personal or family history of thromboembolic events should undergo molecular genetic testing for the presence of thrombophilic mutations.
News Definition and Classification of Chronic Kidney Disease According to KDIGO
We provide a brief overview of the definition and classification of chronic kidney disease based on the updated KDIGO (Kidney Disease: Improving Global Outcomes) clinical practice guidelines from 2012 (published in 2013).
News Alternative to benzodiazepines or clomethiazole in the treatment of alcohol withdrawal syndrome?
Alcohol withdrawal syndrome (AWS) is a potentially life-threatening condition. A meta-analysis published in the journal Pharmacopsychiatry in September 2019 examines the effect of the combination of tiapridal and carbamazepine in the treatment of AWS. Is this combination a viable alternative to benzodiazepines or clomethiazole?
News When and why to consider the diagnosis of myasthenia gravis in neurological practice, and what treatment options do we currently have?
Myasthenia gravis (MG) is a clinically heterogeneous disease characterized by fluctuating muscle weakness and fatigability that worsens after physical exertion or mental stress. Accurate diagnosis is essential because treatment can lead to permanent remission and full functional capacity of the patient.
News Prof. Petr Marusič: Is the Success of Therapy Changing with the Arrival of New Antiepileptics?
At the XXV. postgraduate course in epileptology, 'Jiří Dolanský Days', prof. MUDr. Petr Marusič, Ph.D., from the Neurological Clinic of the 2nd Faculty of Medicine, Charles University, and Motol University Hospital, lectured on the topic of changes in the efficacy of epilepsy treatment with the arrival of new anti-seizure medications.
News Diosmin and Hesperidin: What Does Pharmacokinetics Show?
Flavonoids are plant-derived compounds that have a number of beneficial pharmacological effects. Among the most well-known flavonoids, alongside rutin, are diosmin and hesperidin, which are used as venotonics and vasoprotectives in chronic venous insufficiency (CVI).
News Efficacy and Safety of Ozanimod in the Treatment of Relapsing-Remitting MS
The sphingosine-1-phosphate receptor (S1PR) modulator ozanimod has recently been approved for the treatment of active relapsing-remitting multiple sclerosis (RRMS). We summarize the current knowledge on its mechanism of action and the results of available studies evaluating its efficacy and safety.
News Ozanimod Expands Treatment Options for Ulcerative Colitis in Adult Patients
As a review article published last year in the journal Drugs suggests, ozanimod is an effective and well-tolerated medication for adult patients with moderate to severe ulcerative colitis (UC), both in the initial phase of treatment and in the maintenance phase after achieving remission.
News Two Current Perspectives on the Importance of (Par)enteral Nutrition in Cancer Patients
Adequate (par)enteral nutrition is crucial for cancer patients in terms of prognosis and quality of life. The following recent studies examined parenteral nutrition as an alternative to ileostomy in patients with colorectal anastomosis and muscle mass loss in patients with metastatic cancer.