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News How do IL-17 and IL-23 inhibitors fare in the treatment of psoriasis in direct comparison?

A recent study published in the British Journal of Dermatology is only the second paper to provide a direct comparison of the efficacy and onset speed of treatment with IL-17 and IL-23 inhibitors in patients with moderate to severe plaque psoriasis. The authors monitored the early response to treatment (at week 12), and the efficacy and safety of ixekizumab and guselkumab.

Source: Biological Treatment 3. 4. 2020

News Early Implementation of Highly Effective Therapy for Multiple Sclerosis

The ongoing debate about changing the approach to treating relapsing-remitting multiple sclerosis (RRMS) from an escalation strategy to the early implementation of highly effective therapy (HET) is based on the documented high inflammatory activity of the disease in its early stages and the concept of a therapeutic window for its suppression shortly after diagnosis. We bring you a summary of several recent pieces of information about the benefits and safety of HET as an initial treatment for RRMS.

Source: Neurology - Multiple Sclerosis 20. 9. 2023

News Thromboprophylaxis as a Common Part of Care for At-Risk Patients Requiring Hospitalization: Yes or No?

The proportion of patients requiring hospitalization who are at high risk of developing thromboembolic disease is relatively high. However, not all of these patients have this risk identified and thromboprophylaxis initiated.

Source: Thromboprophylaxis 28. 5. 2021

News What are the patients' needs during acute phase schizophrenia therapy and how to increase their adherence?

Treatment of an acute episode of schizophrenia usually requires hospitalization in a psychiatric ward. Even though hospitalization causes discomfort and represents a burden for many patients, it enables quick and relatively precise diagnosis and timely initiation of adequate treatment and monitoring of its effectiveness. Recommended practices guide how to conduct such diagnostics and therapy. One of the symposiums at the 65th Czech-Slovak Psychopharmacological Conference, which took place in mid-January 2023 in Mariánské Lázně, also focused on the management of care for these patients during the first days of hospitalization and after discharge from acute inpatient care.

Source: Modern Treatment of Schizophrenia 21. 2. 2023

News Longer survival without liver transplant in patients with PBC treated with OCA?

Obeticholic acid (OCA) is a second-line treatment for patients with primary biliary cholangitis (PBC) who have an inadequate response to ursodeoxycholic acid (UDCA) or intolerance to it. The study presented below, the results of which were recently published, examined the effectiveness of OCA in reducing cholestatic enzymes as well as the length of survival without liver transplant in patients with PBC.

Source: Primary Biliary Cholangitis 20. 3. 2023

News Interaction of the 'Big Five' Helps Predict Depression

Experts refer to the 'Big Five' as a personality model that encompasses the following five dimensions: openness to experience, conscientiousness, extraversion, agreeableness, and neuroticism. Can this model be helpful in diagnosing depression?

Source: Depression and Anxiety 5. 10. 2020

News Update of International Recommendations for the Diagnosis and Treatment of Hereditary Angioedema from 2021

The aim of the 2021 update of the recommendations for the diagnosis and treatment of hereditary angioedema (HAE) is to help doctors answer important clinical questions: How to diagnose HAE? When and what prophylactic treatment to administer? What are the treatment goals? How do treatment of children and pregnant women differ? How to monitor disease activity, its impact, and control?

Source: Hereditary Angioedema 18. 5. 2022

News The Potential of Vinpocetine in the Treatment of Cardiovascular Diseases

Vinpocetine is a nootropic indicated for the symptomatic treatment of cerebral ischemic hypoperfusion, vascular dementia, and reducing the psychological and neurological consequences of cerebral blood supply disorders. Due to its excellent safety profile, tolerance, and complex mechanism of action, it is currently being studied in experimental models of various disorders such as obesity and cardiovascular (CV) diseases including atherosclerosis, neointimal hyperplasia, vasoconstriction, pathological heart remodeling, and ischemic stroke (iCMP). We present an overview of the research findings on vinpocetine in CV diseases.

Source: Pain Management 29. 5. 2024

Články časopisu Guidelines of the Czech Society of Hepatology for diagnosis and treatment of primary biliary cholangitis

Author of the article: T. Fejfar, T. Vaňásek, P. Hůlek, L. Vítek, S. Fraňková, R. Brůha Source: Gastroenterologie a hepatologie | 2/2018 4. 5. 2018

Články časopisu Czech Society of Hepatology guidelines for diagnosis and treatment of acute porphyrias

Author of the article: R. Brůha, L. Vítek, J. Šperl, P. Urbánek Source: Gastroenterologie a hepatologie | 2/2017 21. 4. 2017

News Postoperative Bleeding in Children with Hypofibrinogenemia Induced by Cardiopulmonary Bypass

Patients undergoing cardiac surgery with the use of cardiopulmonary bypass are at risk of up to a 40% reduction in plasma fibrinogen levels, with subsequent risk of perioperative bleeding. Children undergoing surgery for congenital heart defects are even more sensitive to the reduction in fibrinogen. What are the possible solutions, and is any one of them significantly better?

Source: Life-threatening Bleeding 7. 7. 2022

News Expression of PD-L1 as a Predictive Biomarker for Therapy Selection in mRCC

A newly published systematic review and meta-analysis of studies involving patients with metastatic renal cell carcinoma (mRCC) evaluates the predictive significance of PD-L1 expression in the treatment with immune checkpoint inhibitors.

Source: Kidney Carcinoma 1. 7. 2021

News Focus on the Connections Between Gastroesophageal Reflux Disease and COPD Exacerbations

In recent years, evidence has emerged of a higher prevalence of gastroesophageal reflux disease (GERD) in patients with chronic obstructive pulmonary disease (COPD). GERD symptoms are more common in them, especially in patients with severe COPD and frequent exacerbations. Why is this, and what direct links can be traced between the two diseases?

Source: Treatment of Asthma and COPD 1. 9. 2020

News What affects the elimination of bisoprolol in diabetics and patients with acute coronary syndrome?

Beta-blockers are widely used to reduce cardiovascular (CV) risk in a number of diseases. However, information about the pharmacokinetics of these drugs is still far from complete. Two studies focused on the population pharmacokinetics (PopPK) of bisoprolol in patients with type 2 diabetes mellitus (DM2) and ischemic heart disease (IHD), and we summarize their conclusions.

Source: Cardiovascular Continuum 16. 9. 2022

News Impact of Vitamin D Deficiency on Inflammatory Cytokine Concentrations in Patients with Diabetic Foot Syndrome

Vitamin D deficiency is relatively common in the population. Vitamin D plays an important role, among other things, in the functioning of the immune system. The aim of the presented study was to determine whether there is a connection between vitamin D levels and the profile of inflammatory cytokines in patients with wound infections in the context of diabetic foot syndrome.

Source: Wound Healing 18. 6. 2020