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News The Choice of Incontinence Aids Matters − But How Not to Get Lost Among Them?
Despite significant advances in medicine, a large number of patients still struggle with incontinence, which limits their comfort and reduces their quality of life. If treatment options have been exhausted, these patients rely on the use of incontinence aids, and therefore every urologist and general practitioner should be familiar with the current offerings and their applications.
News Metformin in Pregnancy and Its Safety Profile
In Finland, a comprehensive analysis of data from the national registry was conducted to assess whether exposure to metformin during intrauterine development is associated with an increased risk of long-term or short-term health problems.
News Patient with a History of DOAC Usage in Neurological ICU with Stroke – Case Study
How should we approach patients with a stroke who are taking direct oral anticoagulants (DOACs) and correctly assess the situation? When should we administer the available antidote according to guidelines? The following case study from the Regional Hospital Liberec illustrates this increasingly common situation.
News Spiolto Respimat System – Innovation for Easier Inhalation
Inhalation delivery is the most preferred method of drug administration in chronic obstructive pulmonary disease and bronchial asthma. The effectiveness of therapy is also conditioned by the correct inhalation technique. The aim of the following article is a brief comparison of inhalation systems, focusing on a new addition to the group of aerosol inhalers.
News Pregabalin in the Hands of a General Practitioner
A recent Cochrane systematic review by authors from Oxford University examined the effect of pregabalin in the treatment of postherpetic neuralgia and diabetic neuropathy – conditions that general practitioners frequently encounter in their practice. Is pregabalin a suitable choice in these indications?
News How Does Artificial Intelligence Help in Drug Development?
In recent years, technologies leveraging artificial intelligence have transitioned from potentially interesting novelties to real clinical development programs. What can artificial intelligence offer the development of new drugs?
News Pain Management After Day Surgery
Effective pain control is a crucial part of recovery for patients after painful surgical procedures. In clinical practice, combined analgesia using paracetamol and nonsteroidal anti-inflammatory drugs (NSAIDs) is commonly utilized, which, however, is not suitable for up to a quarter of patients. An alternative could be metamizole. A study published in the European Journal of Anaesthesiology evaluated the non-inferiority of the combination of paracetamol/metamizole versus paracetamol/ibuprofen in pain management for patients after day surgery.
News Lurasidone in the Treatment of Adolescent Schizophrenia: How Does It Compare with Other Atypical Antipsychotics?
A meta-analysis of 13 studies comparing lurasidone with other atypical antipsychotics in monotherapy for adolescent patients with schizophrenia evaluated the effectiveness of the treatment, the rate of weight gain, and the frequency of medication discontinuation for each modality.
News MUDr. Jana Zárubová: Experiences with buccal midazolam in real practice are positive and we can significantly improve patients' quality of life
Recently, it has emerged as an alternative to traditionally rectally administered diazepam for stopping prolonged convulsive seizures in patients with epilepsy. What can buccal midazolam offer them and how has it proven itself in real practice? MUDr. Jana Zárubová from the Neurological Clinic of the 2nd Faculty of Medicine, Charles University and Motol University Hospital in Prague describes.
News American Heart Association: Side Effects of Statins Overview and Context
The American Heart Association (AHA) report provides an updated summary of knowledge on the safety of statin use. Despite warnings appearing in professional literature and general media, it assures that statins are an effective and safe modality for treating hypercholesterolemia.
News Impact of Azacitidine Maintenance Therapy on Survival of Patients with AML in Remission Depending on Initial Chemotherapy
The QUAZAR AML-001 study showed that oral azacitidine maintenance therapy significantly prolongs relapse-free survival (RFS) and overall survival (OS) in patients with acute myeloid leukemia (AML) in first remission after intensive chemotherapy (including induction ± consolidation therapy), who are not candidates for hematopoietic stem cell transplantation (HSCT), compared to placebo. In October 2023, results of a subgroup analysis of patients stratified according to the use/non-use of consolidation chemotherapy and the number of consolidation chemotherapy cycles administered before entering the study were published.
News Perioperative Management in Patients with Atrial Fibrillation Treated with NOACs
The recommended procedures for perioperative management in patients using novel oral anticoagulants (NOACs) stem from the requirement to minimize treatment interruption before and after surgical procedures to reduce the risk of bleeding and thromboembolism. The safety of these regimens in patients with atrial fibrillation was examined in the prospective PAUSE study presented below.
News Comparison of BEAM and TEAM Conditioning Regimens Before Autologous Hematopoietic Stem Cell Transplantation in the Treatment of Lymphomas
At the beginning of this year, one of the few studies comparing the most commonly used conditioning regimen before autologous hematopoietic stem cell transplantation (ASCT) in patients with lymphomas (BEAM) with a regimen containing thiotepa instead of carmustine (TEAM) was published.
News Results of Levothyroxine Treatment in Pregnant Women with Recurrent Pregnancy Losses with Subclinical Hypothyroidism or Anti-TPO Antibody Positivity
A recent meta-analysis of 15 studies involving a total of 1911 women with a history of recurrent pregnancy losses and positivity for thyroid peroxidase antibodies (TPOAb) or subclinical hypothyroidism showed the benefits of administering levothyroxine on pregnancy outcomes. Women with TPOAb experienced reductions in preterm births, miscarriages, premature rupture of membranes, and fetal growth retardation. Women with subclinical hypothyroidism saw an increase in live births and a decrease in miscarriages.
News Anabolic Antiosteoporotic Treatment as a First Step in Patients with Very High Fracture Risk
According to the 2022 opinion of the ESCEO (European Society for Clinical and Economic Aspects of Osteoporosis, Osteoarthritis and Musculoskeletal Diseases) working group, it is advisable to identify patients with osteoporosis who have a very high risk of fracture and to use an anabolic antiosteoporotic drug as the initial pharmacotherapeutic intervention, followed by necessary antiresorptive treatment to be addressed over the entire expected length of life.
News Don't Hesitate to Refer a Patient to the MS Center: Time is Brain! Or What Recent Czech Research Has Shown?
Time is crucial for every disease, but it is doubly true for diseases of the nervous system! Why is it important to diagnose and treat multiple sclerosis (MS) early? How to do it? And how are we doing with speed here in the Czech Republic?
News Recent findings on the role and potential of L. reuteri in the therapy of GIT diseases
Probiotics contain bacterial or yeast strains similar to beneficial types naturally occurring in the human gastrointestinal tract. Their role in the therapy of gastrointestinal diseases has been extensively researched, demonstrating significant effects on a number of nosological units. One modality of probiotic therapy involves the administration of the bacteria L. reuteri, specifically the laboratory-modified strain DSM 17938.
News Fatigue as a Significant Symptom of Immune Thrombocytopenia from the Patients' Perspective
The I-WISh survey assessed the impact of immune thrombocytopenia (ITP) and its treatment on patients' lives. Patients identified fatigue as the most frequent, severe, and persistent symptom associated with ITP, unlike doctors who did not attribute such significance to this symptom. Recently published survey results also showed that patients need support from multiple sources, including doctors, family, friends, and patient groups.
News Atectura® and Enerzair® from May 1, 2021 with Health Insurance Coverage
The fixed combination of indacaterol acetate (LABA) and mometasone furoate (ICS) Atectura® and the fixed triple combination, which in addition to these two substances also includes glycopyrronium bromide (LAMA), Enerzair® for maintenance inhalation treatment of bronchial asthma, approved in the EU last year, have established health insurance coverage in the Czech Republic from May 1, 2021. We bring a summary of the conditions for reimbursement.
News Pregabalin in Seniors Confirmed Its Safety and Effectiveness
A pooled analysis of 11 studies investigated the safety and effectiveness of pregabalin in seniors with neuropathic pain. Are the outcomes in these indicators different for older individuals than in the general population sample?
News Anxiety Disorders and Autoimmune Thyroiditis – A Connection Rather Than Coincidence?
Anxiolytics commonly target the central nervous system. Newly published research by Ukrainian authors offers a different perspective – according to their findings, anxiety may be related to thyroid inflammation.
News Tapentadol Hydrochloride in Clinical Practice – To Whom, When, How, and Why?
Thanks to its specific properties, tapentadol hydrochloride ranks among the most effective opioids for managing chronic non-cancer pain. Unlike most opioids, it also exhibits an analgesic effect in neuropathic pain. The following brief overview summarizes its mechanism of action and resulting benefits, reimbursement and prescription conditions, its place in the pain management algorithm, and examples of its application in clinical practice.
News Does Peritoneal Dialysis Have Its Place Even in Acute Cases?
In patients who urgently need to replace kidney function, hemodialysis traditionally played the role of the gold standard. Can peritoneal dialysis fully replace it?