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News New Alternative in the Treatment of Diffuse Large B-cell Lymphoma

For patients with relapsed or refractory diffuse large B-cell lymphoma (DLBCL) who are not suitable candidates for autologous stem cell transplantation, a wide range of treatment regimens is available. Recently, the addition of polatuzumab vedotin to rituximab and bendamustine therapy has shown promising efficacy in both registration studies and real-world clinical practice.

Source: Non-Hodgkin Lymphomas and CLL 4. 1. 2021

News Doc. Debora Karetová: Do Not Underestimate the Complexity of CHVO Treatment and Early Stages of the Disease

Are you applying the optimal approach to the treatment of chronic venous disease? What do the new Czech recommendations bring? And what is the current role of venopharmacs in treatment management? You can read all about this in an interview with the chair of the Czech Angiological Society ČLS JEP Doc. MUDr. Debora Karetová, CSc., from the 2nd Internal Clinic –⁠ Clinic of Cardiology and Angiology at the 1st Faculty of Medicine, Charles University, and General University Hospital in Prague.

Source: Venous Insufficiency 12. 9. 2022

News New Recommendations for Intravenous Thrombolysis in the Treatment of Acute Ischemic Stroke –⁠ ESO Guidelines 2021

Intravenous thrombolysis is the only approved systemic reperfusion therapy for patients with acute ischemic stroke (AIS). The most commonly used thrombolytic is alteplase. Earlier this year, the European Stroke Organisation (ESO) issued new evidence-based recommendations for this clinical situation. They contain 40 points, summarized below are the most important ones.

Source: Anticoagulant Treatment 1. 7. 2021

News Pharmacotherapy of Chronic Heart Failure with Reduced EF LV -⁠ Latest ESC Recommendations

The European Society of Cardiology (ESC) issued an update in 2021 for the diagnosis and treatment of heart failure. We summarize the essential points regarding the pharmacotherapy of chronic heart failure with reduced ejection fraction.

Source: Chronic Heart Failure and Lipidology 22. 11. 2021

News COPD is Treated Differently Across Europe –⁠ What Could Be the Reasons for This Variability?

As part of this year's Hradec Pneumological Days (HPD 2022), the head of the Pulmonary Clinic at Charles University Faculty of Medicine and University Hospital Hradec Králové, Assoc. Prof. Vladimír Koblížek, M.D., Ph.D., reflected on the different rates of prescription of mucoactive drugs to COPD patients in various European countries. According to him, it is clear that in real practice, this treatment works. So what is the reason for its varying prescription across the old continent?

Source: Cough Therapy 24. 5. 2022

News Ligamentous Changes as a Harbinger of Cardiac Amyloidosis –⁠ Histopathological and Clinical Study

Amyloid deposits can be present in various types of tissue. Their accumulation in connective tissue can lead to pathological changes resulting in the rupture of stressed structures (e.g., the Achilles tendon) or stenosis in areas where blood vessels and nerves pass through (e.g., carpal tunnel syndrome). Swedish doctors focused on patients with lumbar spinal stenosis to analyze how often this diagnosis is associated with amyloid deposits.

Source: Amyloidosis 10. 4. 2023

Články časopisu Uterine laceration –⁠ a rare case of postpartum hemoperitoneum

Author of the article: Macedo Silva Carlos, Domingos Pestana Cristina, Gomes Leiria Rita, Pina Zeferino, Dias Fátima Maria Source: Česká gynekologie | 5/2021 18. 10. 2021

News Prevalence of Heart Failure and Its Subtypes in the Population of Developed Countries

In developed countries, heart failure occurs in approximately 2% of the population, with an annual incidence of 5-10/1000 inhabitants. The mortality rate for patients with chronic heart failure is 7.2% per year, and 31.9% of patients with heart failure are hospitalized annually. Portuguese authors attempted to assess the prevalence of heart failure and its subtypes in a population treated within one healthcare facility over 3 years.

Source: Heart Failure 2. 1. 2023

News High pH of Wounds is Associated with Poorer Burn Healing

British scientists have shown that the pH of burn wounds decreases during healing and that higher pH at the second dressing change is associated with poorer healing and the subsequent need for skin grafts. Determining the pH of wounds at the beginning of treatment could help identify poorly healing burns that require more aggressive treatment.

Source: Wound Healing 24. 2. 2020

News Romiplostim in Newly Diagnosed ITP Resistant to 1st Line Treatment –⁠ Case Study

In patients with immune thrombocytopenia (ITP), effectively stopping and controlling bleeding can be complicated in some cases. This includes scenarios such as open wounds. One way to stabilize platelet count can be through administering a thrombopoietin receptor agonist (TPO-RA). The following case study presents a successful treatment of newly diagnosed ITP.

Source: Immune Thrombocytopenia 2. 10. 2023

News Impact of Administering Omega-3 Fatty Acids on the Risk of Metabolic Syndrome in Patients with Schizophrenia

The aim of the Polish clinical study OFFER was to assess the possibility of influencing the risk of developing metabolic syndrome (MetS) and some of its individual components in patients with first-episode schizophrenia by supplementing with eicosapentaenoic acid (EPA) and docosahexaenoic acid (DHA).

Source: Modern Treatment of Schizophrenia 13. 12. 2022

Články časopisu Idiopathic pulmonary fibrosis. Can we always diagnose and treat it right?

Author of the article: Martina Vašáková Source: Vnitřní lékařství | 11/2017 2. 1. 2018

News Current Findings on Progressive Fibrosis in Interstitial Lung Disease

Leading pulmonologists around the world recently published the first of a series of three review articles on interstitial lung disease in The Lancet Respiratory Medicine journal. This article focuses on histopathology and the relationship of this disease with lung fibrosis. It also addresses the question of whether progressive lung tissue fibrosis pertains only to usual interstitial pneumonia.

Source: Progressive Interstitial Pulmonary Processes 8. 9. 2022

News Romiplostim Before Splenectomy in a Patient with ITP -⁠ Case Report

In the following case report from authors at a university hospital in Barcelona, the successful use of romiplostim as a second-line treatment before planned splenectomy in a patient with immune thrombocytopenia (ITP), liver cirrhosis, and iatrogenic Cushing's syndrome is demonstrated.

Source: Immune Thrombocytopenia 25. 11. 2022

News Effect of Romiplostim in Refractory ITP with Possibility of Maintaining Response Without Treatment –⁠ Case Report

This case report from the United States features an ideal therapeutic response to romiplostim in a patient with refractory immune thrombocytopenia (ITP). After several years of successful therapy, the medication could even be gradually discontinued while maintaining the therapeutic response.

Source: Immune Thrombocytopenia 25. 10. 2022