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News Omalizumab and Treatment of Severe Refractory Asthma in Pregnant Women

Omalizumab is commonly recommended for the treatment of severe refractory asthma. A special group of patients are pregnant women with asthma, for whom the risks of inadequately treated asthma must be weighed against the risks of biological treatment for the fetus. EXPECT is a pregnancy registry that has served since 2006 as a prospective observational study; its aim is to collect data on women treated with omalizumab during pregnancy and compare it with data from asthmatic women who did not receive omalizumab.

Source: Asthma under control 11. 5. 2020

News How does the level of uric acid affect the incidence of cardiorenal events in patients with T2DM and CVD?

One of the post hoc analyses of the well-known EMPA-REG OUTCOME study provided data on the relationship between uric acid levels and the incidence of cardiorenal events in type 2 diabetics with existing cardiovascular disease.

Source: Diabetes 21. 7. 2023

News View on the Treatment of Rheumatoid Arthritis with Baricitinib Using the NNT Indicator

Clinical parameters assessed by patients themselves are an important tool in evaluating the effectiveness of new drugs and are particularly significant in the evaluation of treatments for chronic painful conditions, such as rheumatoid arthritis (RA). An analysis of clinical trial results presented at the European Rheumatology e-Congress in June 2020 focused on the effectiveness of the Janus kinase inhibitor baricitinib on parameters assessed directly by patients. Effectiveness was analyzed using the NNT indicator.

Source: Biological Treatment 30. 11. 2020

News Excellent effect of sotorasib in a higher line of treatment in a patient with NSCLC with G12C mutation of KRAS –⁠ a case study

We present a case study of an elderly patient with non-small cell lung cancer (NSCLC) treated with the selective KRASG12C inhibitor sotorasib in the 5th line of oncological treatment, but with a very exceptional effect.

Source: Lung Cancer 30. 10. 2024

News Should patients with primary immunodeficiencies fear COVID-19 more than the general population?

The body fights the new SARS-CoV-2 virus, which causes COVID-19, in a similar way to other viral infections -⁠ by intensely engaging the immune system. But what if it's weakened?

Source: Primary and Secondary Immunodeficiencies 7. 5. 2020

News Analysis of Data from the EMPEROR-Preserved Study Revealed Whether Blood Pressure Affects the Effectiveness of Empagliflozin in Patients with Heart Failure with Preserved Ejection Fraction

Hypertension is among the most common etiological factors of heart failure with preserved ejection fraction (HFpEF), where pressure overload of the left ventricle leads to its eccentric hypertrophy and diastolic dysfunction. According to recent study results, empagliflozin significantly reduces the risk of cardiovascular (CV) complications in patients with HFpEF. The EMPEROR-Preserved sub-analysis further examined the impact of baseline systolic blood pressure (sBP) on treatment outcomes and patient prognosis.

Source: Heart Failure 19. 6. 2023

News Does The Use of Levothyroxine in Women with Thyroid Peroxidase Antibodies Affect The Risk of Miscarriage and Premature Birth?

Women with thyroid peroxidase antibodies have a higher risk of miscarriage and premature birth, even if they have normal thyroid function. The British study presented below aimed to clarify whether the use of levothyroxine affects the incidence of these complications.

Source: Thyroid Disorders 10. 2. 2020

News Dust Mite Allergy and the Risk of Sleep-Disordered Breathing

New York authors in their recently published retrospective analysis tested the hypothesis that individuals with allergic rhinitis caused by dust mite allergy have an increased risk of breathing disorders during the REM phase of sleep, based on objective polysomnography evaluation.

Source: Dust Mite Allergy 29. 10. 2021

News Tool for Predicting Cardiometabolic Risk in Young Patients with Psychotic Disorder

A study describing the development and validation of an algorithm for predicting cardiometabolic risk in patients with psychotic disorder, PsyMetRiC (Psychosis Metabolic Risk Calculator), was recently published in Lancet Psychiatry. British scientists have created a tool to estimate the risk of developing metabolic syndrome over the next 6 years, serving as a predictor of cardiovascular morbidity and mortality in young people with psychosis aged 16–35 years.

Source: Modern Treatment of Schizophrenia 13. 12. 2022

News Neutralizing Antibodies Against Emicizumab –⁠ Detailed Analysis Based on a Case Study

Japanese authors investigated the mechanism of reduced efficacy of emicizumab in an adult patient with hemophilia A and an inhibitor, whose treatment was discontinued due to repeated bleeding episodes with prolonged aPTT.

Source: Hemophilia 22. 11. 2021

News Efficacy of Empagliflozin in HFpEF Patients –⁠ Comparison of Subpopulations with Preserved and Mid-Range LV EF

A sub-analysis of the EMPEROR-Preserved clinical trial examined the effects and safety of empagliflozin in patients with heart failure with a left ventricular ejection fraction (LV EF) > 40%. What insights does it provide regarding the impact on cardiovascular (CV) mortality or the need for hospitalization for heart failure (HHF) concerning left ventricular function?

Source: Heart Failure 24. 8. 2023

Články časopisu Exogenous allergic alveolitis in automobile industry –⁠ case report

Author of the article: Kunová Magdalena, Machartová Vendulka, Bejčková Hana Source: Pracovní lékařství | 1/2014 2. 4. 2014

News Care of Dental Dentures According to the Recommendations of the American Society of Dental Prosthetists

Dental dentures are the most common solution for missing teeth in the jaw. They should serve patients for several years, so proper care is essential. Therefore, dental professionals should not only be able to make them perfectly but also provide their patients with quality information about their maintenance. However, individual experts often differ in their recommendations, advising based on their own experiences, and even national dental organizations do not always have these information easily accessible. The American Society of Dental Prosthetists has therefore issued a series of recommendations that can be followed by both doctors and patients or caregivers.

Source: Optimal Care of Dentures 2. 11. 2020

News Which biomarkers can be used for risk stratification in ATTR cardiac amyloidosis?

Effective treatment for patients with transthyretin cardiac amyloidosis requires timely diagnosis and precise risk stratification to identify patients at higher risk of cardiovascular events, heart failure progression, and death. Currently, there are several scoring systems based on commonly available laboratory parameters. Here is a brief overview.

Source: Amyloidosis 11. 7. 2023

News Comparison of Three Thromboprophylactic Regimens in Patients Post Pancreatic Surgery

Post-pancreatectomy bleeding and thromboembolic disease are among the serious complications of pancreatic surgeries. The aim of the study published last year in the British Journal of Surgery was to compare the efficacy and safety of different dosing regimens of low-molecular-weight heparin nadroparin in patients undergoing oncologic pancreatic surgery.

Source: Prevention of Thrombosis in Surgery 18. 5. 2020