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News Diosmin Succeeded in Preventing Ovarian Hyperstimulation Syndrome in Study
In a recently published study, diosmin was evaluated in women undergoing in vitro fertilization (IVF). Attention was focused on its effect in preventing and treating ovarian hyperstimulation syndrome (OHSS).
News What Can We Expect from Sorafenib in the Treatment of Liver Cancer Affected by Nonalcoholic Fatty Liver Disease?
Ubiquitous and increasingly common obesity is a risk factor for many cancers. Over the past 20 years, studies have linked obesity to higher incidences of breast and colorectal cancers, as well as hepatocellular carcinoma (HCC) associated with nonalcoholic fatty liver disease (NAFLD). What is the efficacy and safety of sorafenib in this patient population, and does it differ from patients with liver cancers caused by viral infection or alcohol abuse? This intrigued a team of researchers from Melbourne, Australia.
News Nearly 20 Years with Bevacizumab Has Brought Hope for Patients and Deeper Understanding of Solid Tumors
Bevacizumab is among the first targeted therapies used in oncology. For many indications where chemotherapy options had been exhausted and few other treatment modalities were available, it changed the treatment approach and brought patients prolonged progression-free survival or even overall survival. It has become a standard of care for many advanced cancers. What do we know today about this monoclonal antibody, first introduced in routine practice in 2005?
News Impact of Chronic Urticaria on Patients' Quality of Life and Society
An international team of dermatologists has mapped out the impact of chronic urticaria on various aspects of patients' lives and the economic burden this long-term disease, without available causal treatment, represents for society, according to available literature.
News Mass in the Left Atrium Appendage - Case Report
A symptomatic mass in the left atrial appendage warrants thorough investigation and radical treatment – unless it is in the heart of a polymorbid patient, as was the case in the following report.
News INFOGRAPHIC: Determining the Target Intraocular Pressure in Glaucoma Therapy
The goal of glaucoma treatment is to preserve the visual field and the quality of life of patients. Currently, the only approach to preserving the visual field of patients is to reduce intraocular pressure (IOP). Its target value should be determined for each patient with consideration of individual risk factors. The following comprehensive infographic shows which factors should be considered according to the current recommendations of the European Glaucoma Society (EGS).
News Prof. Roman Chlíbek: Role of Multivalent Pneumococcal Conjugate Vaccines in Healthy and Premature Children
Children are frequent carriers of pneumococci, which can cause both common non-invasive and more severe, life-threatening invasive pneumococcal diseases, especially in children under 1 year of age and in people over 65 years old. Almost a year ago, a pediatric indication for a 15-valent pneumococcal vaccine was approved, which is enriched with 2 new serotypes and, according to study results, appears to be potentially more effective even in protecting against serotype 3. So what are the vaccination options for healthy immunocompetent children, and what benefits does this vaccine offer for premature infants? Professor Roman Chlíbek, chair of the Czech Vaccinology Society ČLS JEP, answered these questions in his presentation at the June Interdisciplinary Conference of PLDD.
News PHD 2022: In the treatment of multiple myeloma we have achieved significant progress, confirm real-world data
The treatment options for multiple myeloma (MM) have significantly advanced over the past 10 years, and patient outcomes have improved. However, the most accurate guide is needed to select the right treatment modality for each particular patient among the many available options. During the Prague Hematology Days (PHD) 2022, this topic was addressed by Prof. MUDr. Roman Hájek, CSc., from the Hemato-Oncology Clinic of the Faculty of Medicine at the University of Ostrava and FN Ostrava.
News Effects of Progestins in Combination with EE on Endothelial Function, Lipid Levels, and Oxidative Stress in Women with Endometriosis
Studies have shown endothelial dysfunction and increased oxidative stress in women with endometriosis. Theoretically, they may be at increased cardiovascular risk. The study presented below investigated the effects of progestins with or without androgenic properties in combination with ethinylestradiol (EE) on endothelial function, lipid levels, and oxidative stress in women with endometriosis.
News Water Microjet as a Gentler Method of Debridement
Debridement is an integral part of chronic wound treatment. Currently, the most common method is mechanical debridement, which involves the use of sharp tools or abrasive materials to remove necrotic tissue. However, this method can be painful, imperfect, and associated with the risk of damaging healthy tissue. New and gentler methods are emerging, promising improved therapeutic outcomes, such as the use of a water microjet.
News Metamizole in Pain Management for Patients with Subarachnoid Hemorrhage
A study by Czech authors from the University Hospital St. Anna in Brno, recently published in the British Journal of Neurosurgery, evaluated analgesic treatment in patients with subarachnoid hemorrhage. The use of metamizole as the primary analgesic was associated with a significantly lower risk of adverse clinical outcomes at 2 weeks and 6 months compared to other non-opioid and opioid analgesics.
News Current Findings on Progressive Fibrosis in Interstitial Lung Disease
Leading pulmonologists around the world recently published the first of a series of three review articles on interstitial lung disease in The Lancet Respiratory Medicine journal. This article focuses on histopathology and the relationship of this disease with lung fibrosis. It also addresses the question of whether progressive lung tissue fibrosis pertains only to usual interstitial pneumonia.
News COPD is Treated Differently Across Europe – What Could Be the Reasons for This Variability?
As part of this year's Hradec Pneumological Days (HPD 2022), the head of the Pulmonary Clinic at Charles University Faculty of Medicine and University Hospital Hradec Králové, Assoc. Prof. Vladimír Koblížek, M.D., Ph.D., reflected on the different rates of prescription of mucoactive drugs to COPD patients in various European countries. According to him, it is clear that in real practice, this treatment works. So what is the reason for its varying prescription across the old continent?
News Extended Thromboprophylaxis with Enoxaparin After Bariatric Surgery
A recent retrospective study involving 312 patients after bariatric surgery indicated that extended thromboprophylaxis might be an appropriate approach for preventing postoperative venous thromboembolism in these patients. In this study, the authors administered enoxaparin at a dose of 40 mg subcutaneously twice daily for 10-14 days in the majority of operated patients without an increased risk of bleeding.
News Safety and Efficacy of Combination Therapy for Allergic Rhinitis Compared to Monotherapies and Placebo
Combination therapy of antihistamine and corticosteroid is a promising alternative for patients suffering from seasonal allergic rhinitis. A phase II clinical study aimed to determine the effective dosage, efficiency, and safety of combination therapy compared to monotherapies and placebo.
News Early Intervention in the Early Phase of Psychosis
A meta-analysis of 10 randomized studies examined whether early intervention in the initial phase of psychosis in patients with schizophrenia is associated with better outcomes than usual care.
News Efficacy of Bruton Tyrosine Kinase Inhibitors After Venetoclax Therapy in Patients with CLL
Targeted therapy has changed the treatment approach for chronic lymphocytic leukemia (CLL), showing higher efficacy and safety compared to standard chemoimmunotherapy. Until recently, an important question remained unanswered: whether the administration of Bruton tyrosine kinase inhibitors (BTKi) after previous therapy with the BCL-2 inhibitor venetoclax provides sufficient clinical effect.
News Effect of Cataract Surgery on Melatonin Secretion in Adults Aged 60 and Over
A study by ophthalmologists and epidemiologists from Nara University in Japan, recently published in JAMA Ophthalmology, examined the relationship between cataract surgery, the use of clear and yellow intraocular lenses, and the level of melatonin secretion.
News Benefit of Short-term Androgen-deprivation Therapy Added to Radiotherapy of Localized Prostate Cancer for Long-term Survival
Androgen-deprivation therapy is associated with several adverse effects that also affect quality of life or increase the risks of serious age-related health problems. An extensive study focused on the benefits of short-term administration of androgen-deprivation therapy as an adjunct to radiotherapy in patients with prostate cancer and monitored its long-term impact on survival and the rate of late treatment toxicity.
News What is the Impact of Bisoprolol on Plasma Concentrations of Dabigatran
Many patients on anticoagulant therapy with dabigatran also use the beta-blocker bisoprolol. The Slovak prospective observational study was based on the assumption that bisoprolol, as a significant inhibitor of P-glycoprotein, may interact with dabigatran and focused on examining the effect of this beta-blocker on plasma concentrations of dabigatran.
News EHL preparations have the potential to change the quality of life for people with hemophilia
Within the therapeutic modalities for hemophilia, the current era offers a number of preparations. Newer extended half-life (EHL) replacement therapies can provide hemophiliacs with better protection against bleeding and allow for greater physical activity.
News Improving treatment outcomes of HF with preserved ejection fraction according to JACC: What does the success of gliflozins mean for the future?
The Journal of the American College of Cardiology (JACC) recently issued a scientific statement in which the authors thoroughly examined current knowledge on the epidemiology, pathophysiology, diagnosis, and treatment of heart failure with preserved ejection fraction of the left ventricle (HFpEF). Recent studies in this heterogeneous disease suggest the importance of carefully determining the HFpEF phenotype in a given patient based on pathophysiology, which enables better individualization of treatment. The authors also reflect on the success of gliflozins in treating HFpEF and how HFpEF pharmacotherapy can be further improved.
News Position of Parenteral Therapy in Patients with Severe COVID-19 Disease
Patients with severe COVID-19 disease are at risk of developing acute respiratory insufficiency requiring non-invasive or invasive pulmonary ventilation. Intensive care therapy is associated with a high risk of severe malnutrition. According to current recommendations by the European Society for Clinical Nutrition and Metabolism, parenteral therapy plays an important role in the nutrition of patients.