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News Dabigatran as Effective Prevention of VTE Recurrence Also in Patients with Thrombophilia
With increasing positive experience with direct oral anticoagulants, the question arises of how these drugs work in different groups of patients − for example, in those who have a congenital or acquired thrombophilic state.
News Alemtuzumab – Does Age Matter? Or Not?
The authors of a study published this year focused on the safety and efficacy of alemtuzumab in patients with relapsing-remitting multiple sclerosis (RRMS). How did it perform over the observed period in patients of different age categories?
News Clinical Profile and Outcomes of Patients with Cardiac Amyloidosis – Spanish Experience from Real Practice
Cardiac amyloidosis is caused by the deposition of amyloid fibrils in the myocardium and is among the diseases with significant diagnostic delay. Physicians from the University Hospital in Madrid shared their experiences with the diagnosis and treatment of these patients over the last decade in the cited work below.
News How did alemtuzumab fare in real clinical practice?
A study published by authors from the University of Massachusetts in January this year in the journal Multiple Sclerosis and Related Disorders focused on the effectiveness and safety of alemtuzumab. How did it fare in real clinical practice?
News Tofacitinib in the Treatment of Ulcerative Colitis in Real-World Practice in the USA
A recently published study summarizes the characteristics of patients newly treated with tofacitinib for ulcerative colitis (UC), the impact of initiating tofacitinib on corticosteroid use, and adherence to this treatment in real-world practice based on a retrospective analysis of data from a large health database in the USA.
News Water Microjet as a Gentler Method of Debridement
Debridement is an integral part of chronic wound treatment. Currently, the most common method is mechanical debridement, which involves the use of sharp tools or abrasive materials to remove necrotic tissue. However, this method can be painful, imperfect, and associated with the risk of damaging healthy tissue. New and gentler methods are emerging, promising improved therapeutic outcomes, such as the use of a water microjet.
News INFOGRAPHIC: Post-Induction Therapy for AML – Current Guidelines
What are the recommended therapeutic modalities for consolidation and maintenance therapy of acute myeloid leukemia (AML) in patients over 60 years of age? We present a clear therapeutic algorithm according to the current recommendations of the American National Comprehensive Cancer Network.
News How TPO-RA Drugs Fared in Meta-Analyses of Safety and Efficacy in ITP Patients
Meta-analyses regarding the use of thrombopoietin receptor agonists (TPO-RA) evaluated their efficacy and safety in the treatment of primary immune thrombocytopenia over long-term follow-ups. What findings did they uncover?
News Can Thyroid Hormone Supplementation Reduce the Risk of Cognitive Disorders?
The recent systematic literature review presented below, published by authors from the California Institute of Behavioral Neurosciences and Psychology (CIBNP), focused, among other things, on potential associations between hypothyroidism and dementia and the impact of related therapeutic interventions in terms of improving cognitive functions.
News Subcutaneous zilucoplan – the end of necessary “trips” to the hospital for myasthenia gravis patients?
A study recently published in Lancet Neurology demonstrated the efficacy and safety of the subcutaneously administered complement component C5 inhibitor – zilucoplan – in the treatment of myasthenia gravis (MG). This drug has the potential to alleviate the severity of this disease and improve the quality of life of patients.
News Long-term Safety of Dupilumab in Adult Patients with Moderate to Severe Atopic Dermatitis
Moderate to severe atopic dermatitis (AD) often requires systemic therapy. The long-term safety of dupilumab in patients with this condition was evaluated in an open-label extension (OLE) of the LIBERTY AD study, the results of which were recently published.
News Will up-titration or combination with bisoprolol help to better control hypertension in amlodipine users?
Will patients with hypertension who do not achieve control of this condition with amlodipine at a dose of 5 mg benefit more from up-titration or combining it with bisoprolol? The answer to this question was sought in a study published this year by German authors.
News Analysis of the Benefits of Combining Enalapril/Bisoprolol in Patients with Acute MI
A recently published retrospective analysis compared the outcomes achieved by administering enalapril alone and in combination with bisoprolol in patients after acute myocardial infarction over a period of 1 year.
News Use of Targeted Therapy with Dupilumab in Patients with Allergic Diseases
Interleukins (IL) 4 and 13 play an important role in the pathogenesis of allergic diseases. Their blockade is therefore a suitable strategy for a number of these conditions. This is offered by the new monoclonal antibody dupilumab (Dupixent), which is approved for the treatment of atopic dermatitis, asthma with type 2 inflammation, and chronic rhinosinusitis with nasal polyposis. Studies are ongoing to evaluate its efficacy in other diseases where type 2 inflammation predominates.
News Potential, Benefits and Proper Use of Probiotics in the Treatment of Acute Gastroenteritis in Children
Clinical studies and experiences from clinical practice have shown the benefits of administering probiotics in the treatment of acute gastroenteritis in children. Pediatrician Dr. Natália Szitányi summarizes the possibilities and rationale for their use in this indication.
News Is Adding Fibrinogen Concentrate to Transfusion Therapy for Postpartum Hemorrhage an Effective Approach?
Significant postpartum hemorrhage can be managed with fresh frozen plasma transfusion. However, administering larger volumes is associated with several risks. The authors of the Japanese study below investigated whether fibrinogen concentrate added to fresh frozen plasma transfusions is an effective tool in reducing the need for erythrocyte concentrate and whether it helps prevent complications of intensive transfusion therapy.
News Options for Modifying and Improving the Efficiency of the HJHS Scoring System
The Hemophilia Joint Health Score (HJHS) is a validated tool for assessing joint health in individuals with hemophilia. Can it be modified to be used more effectively in clinical practice?
News INFOGRAPHIC: Migraine Treatment Without Mistakes
A practical guide on how to proceed with the diagnosis of migraine, so that the treatment is effective and tailored to the patient.
News New Drug in the Biologic Therapy Arsenal for Plaque Psoriasis
Bimekizumab shows promising effects in clinical studies with psoriasis patients. Let's take a closer look at this recently approved drug in our brief summary.
News How Does Empagliflozin Stand in Terms of Diabetic Retinopathy Risk? We Have Answers Not Only from Controlled Studies but Also from Real Practice
Modern antidiabetics – gliflozins and glucagon-like peptide-1 receptor agonists (GLP-1RA) – significantly help improve the management of type 2 diabetes (DM2). In addition to reliable glycemic control, they offer other benefits. For example, gliflozins are known for their cardio- and renoprotective properties. GLP-1RA also reduce cardiovascular (CV) risk, though clinical evaluation (SUSTAIN-6) suggests a possible higher risk of retinopathy. This is also being investigated with gliflozins. How empagliflozin fares in this respect has been shown by the prospective randomized EMPA-REG OUTCOME study and the real-world EMPRISE evaluation.