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News Reference Intervals of Prostate Health Index (PHI) in Healthy Men

For more specific prostate cancer screening, apart from prostate-specific antigen (PSA), its free fraction (fPSA) and one of its precursors, [-2]proPSA (p2PSA), are used today. From these parameters, the so-called Prostate Health Index (PHI) can be calculated. However, reference intervals for these parameters in a healthy population were not known until now.

Source: Prostate Health Index 2. 4. 2020

News What a Decade of Experience with Tapentadol Hydrochloride in Pain Treatment Has Shown

In an interview with Dr. Marek Hakl, Ph.D., from the Brno Pain Treatment Center, we focus on the role of tapentadol hydrochloride in the treatment of chronic pain. We discuss, among other things, its suitability for specific patients and the latest findings that confirm its excellent efficacy and fewer side effects compared to other opioids.

Source: Updates in Pain Treatment 12. 10. 2023

News Interstitial Lung Processes and Their Fibrotic Progression

Interstitial lung processes (ILPs) include more than 200 clinical units that share diffuse involvement of lung tissue and thus have similar clinical, radiological, and functional findings. However, their broad differential diagnosis is particularly problematic.

Source: Progressive Interstitial Pulmonary Processes 10. 9. 2021

News Association between Hypothyroidism, Depression, and Anxiety Disorder –⁠ Results of Meta-Analyses

The prevalence of autoimmune thyroiditis in the USA ranges between 4 and 13%. Subclinical hypothyroidism affects 3–8.5% of the general population. Patients with this condition are at risk not only from somatic manifestations. The meta-analyses presented below examined the association between hypothyroidism and the incidence of psychiatric disorders –⁠ depressive and anxiety disorders. One of the meta-analyses also evaluated the effect of levothyroxine administration on the incidence of depression in individuals with subclinical hypothyroidism.

Source: Thyroid Disorders 6. 9. 2023

News The Role of the General Practitioner in the Care of Incontinent Patients

General practitioners are sometimes likened to frontline soldiers because they are usually the first to whom patients turn with their health issues. Taking care of incontinent patients is a daily routine for them. They should therefore be knowledgeable about basic diagnostics and treatment and be able to actively identify incontinent patients.

Source: Incontinence 2. 6. 2020

News Side Effects of Metformin: It's Not Just a Nocebo Effect?

If we were to name medications that have the greatest significance from a population standpoint, metformin would certainly be at the top of the list. We have known it for over fifty years and know a lot about it, including its negatives. But is it time to replace it with new drugs? Or is it worth staying with it?

Source: Modern Treatment of Diabetes 11. 9. 2020

News Is It Necessary to Discontinue Dupilumab in Patients with Atopic Dermatitis During the COVID-19 Pandemic?

Italian authors described their experiences with remote treatment of 200 atopic dermatitis (AD) patients using dupilumab during the COVID-19 pandemic outbreak in spring 2020. Observations from clinical practice, published data, and pathophysiological considerations do not suggest an increased risk of SARS-CoV-2 infection in AD patients receiving this biological treatment.

Source: Systemic treatment of atopic dermatitis, asthma, and chronic rhinosinusitis with nasal polyposis – Type 2 inflammation 14. 12. 2020

News Doc. Jiří Kubeš: The major benefit of proton therapy lies in protecting healthy tissues

Nearly 9,000 patients with oncological diseases have already undergone modern proton radiotherapy at the Proton Center in Prague. Which diagnoses are suitable for this treatment modality, what are its main benefits, and what is its place in the comprehensive therapy of malignant tumors? We discuss these topics with the chief physician of this medical facility, Doc. MUDr. Jiří Kubeš, Ph.D.

Source: Proton Radiotherapy 7. 3. 2023

News Fexofenadine –⁠ Non-Sedative and Immunomodulatory Antihistamine in the Treatment of Allergic Symptoms

One of the biggest limitations of traditional antihistamines is the sedative effect on the central nervous system. Newer antihistamines do not cause sedation, are not associated with serious side effects, and some also have immunomodulatory effects.

Source: Viral infections 3. 3. 2022

News Hypertrophic Cardiomyopathy: When Bigger Does Not Mean Better

Hypertrophic cardiomyopathy (HCM) is a hereditary disease that, in some patients, proceeds asymptomatically, while others struggle with arrhythmias or heart failure, and in some individuals, the first manifestation of the disease can be sudden cardiac death. More about the etiology and diagnosis of HCM is discussed in the following overview.

Source: Hypertrophic Cardiomyopathy (HCM) 7. 9. 2023

News Impact of Thyroid Dysfunction on the Cardiovascular System in Elderly Patients

The incidence of thyroid disease increases with age. In the Czech Republic, up to 5% of the population suffers from hypothyroidism, and the prevalence of hyperthyroidism is estimated at 0.2-1%. The following text discusses the impact of these thyroid disorders on the cardiovascular (CV) system in elderly patients.

Source: Thyroid Disorders 2. 11. 2020

Články časopisu Non-Hodgkin lymphomas in the Czech Republic

Author of the article: M. Trněný Source: Transfuze a hematologie dnes | 1/2019 29. 3. 2019

Články časopisu

Author of the article: Šárka Slabá, Iva Málková, Martin Wagenknecht, Karel D. Riegel, Lukáš Junek, Judita Lorencová, Jitka Herlesová, Veronika Koch Ondrová, Pracovní Skupina Psychologické Sekce České Obezitologické Společnosti Čls Jep Source: Časopis lékařů českých | 3-4/2020 31. 7. 2020

News Minimally Invasive Treatment of Pilonidal Sinus: Laser and Negative Pressure Therapy as a Gentle and Effective Modality

The increasing incidence of pilonidal sinus contributes to the development of new treatment methods. Experiences from AGEL Hospital Přerov show that the methods SiLaC (sinus laser ablation of the cyst) and NPWT (negative pressure wound therapy) represent a gentle and effective approach for pilonidal sinus, accelerating treatment and subsequent recovery.

Source: Wound Healing 24. 11. 2023

News Prof. Petr Marusič: Is the Success of Therapy Changing with the Arrival of New Antiepileptics?

At the XXV. postgraduate course in epileptology, 'Jiří Dolanský Days', prof. MUDr. Petr Marusič, Ph.D., from the Neurological Clinic of the 2nd Faculty of Medicine, Charles University, and Motol University Hospital, lectured on the topic of changes in the efficacy of epilepsy treatment with the arrival of new anti-seizure medications.

Source: Epilepsy 2. 12. 2022