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News Neuroprotective Efficacy and Safety of Vinpocetine in Patients with Acute Ischemic Stroke

A meta-analysis of 4 randomized placebo-controlled studies demonstrated the benefits of vinpocetine in patients with ischemic stroke (iCMP). Administering vinpocetine within 14 days of the onset of the stroke significantly reduced the level of disability and the proportion of those who died or were dependent on others after 1 and 3 months. The results showed benefits in several other parameters and indicated very good tolerability of this drug used to increase cerebral blood flow.

Source: Pain Management 13. 5. 2024

News Comprehensive View on Care for Patients with Urostomy

Thanks to improvements in surgical techniques and shorter hospital stays, patients with a stoma are returning to their home environment and to the care of outpatient doctors sooner. Quality care in the postoperative period is a crucial element in the prevention of complications, support of healing, and education of ostomy patients. Doctors caring for these patients should approach them comprehensively, considering all their needs and aspects.

Source: Ostomy 28. 2. 2020

News Most Common Dermatoses Around the Stoma

The incidence of stomal complications ranges between 20 and 70%. One type of complication is dermatoses affecting the peristomal skin. These issues can occur in the early postoperative period, but also several years later.

Source: Ostomy 4. 5. 2020

News Importance of pH in Care for Stoma Patients

Maintaining good quality peristomal skin and preventing complications related to the stoma site are integral parts of comprehensive care for patients with stomas. The pH of the skin also plays an important role in this issue, as it can significantly affect the condition of the skin, the development of complications, the quality of life of patients, and consequently impact the economic aspect of stoma care.

Source: Ostomy 19. 3. 2020

News How Does Erdosteine Perform in Combination with Antibiotics?

Erdosteine is an oral mucoactive drug that reduces mucus viscosity by degrading disulfide bonds in the mucin polymer. It achieves this effect through a free thiol group in its main active metabolite, N-thiodiglycolyl-homocysteine. In addition to its mucolytic action, erdosteine exhibits antioxidant and anti-inflammatory effects and reduces bacterial adhesion, thereby enhancing the effectiveness of certain antibiotics. We provide a summary of study results demonstrating its effect on enhancing the efficacy of drugs administered in the treatment of respiratory diseases.

Source: Cough Therapy 1. 11. 2022

News Is Baricitinib Suitable for Long-Term Treatment of Rheumatoid Arthritis?

The nature of rheumatoid arthritis requires effective and long-term treatment. The current analysis of data from the long-term extension RA-BEYOND reveals the potential of baricitinib in maintaining low disease activity and remission with long-term use.

Source: Biological Treatment 12. 3. 2021

News Subclinical Hypothyroidism in Pregnancy: How Great Are the Real Risks and Can They Be Effectively Reduced?

The aim of the meta-analysis by authors from the Mayo Clinic was to describe the impact of subclinical hypothyroidism on the course of pregnancy and the effect of levothyroxine replacement therapy in reducing the risk of possible complications.

Source: Thyroid Disorders 25. 4. 2023

News How can inosine pranobex help with viral infections?

Inosine pranobex has long been used for its immunomodulatory and antiviral effects in the prophylaxis and therapy of various viral infections. Below we summarize its mechanism of action, indications, usage, and side effects.

Source: Viral infections 16. 2. 2023

News Gut-Brain Axis −⁠ Future of MS Treatment?

The relationship between the gut microbiome and multiple sclerosis has been a major topic recently. How far has current science progressed in decoding this issue? A recent review article published in the journal Neuroscience Research summarizes the existing findings on the relationship of the gut microbiome to the etiopathogenesis and course of multiple sclerosis (MS).

Source: Multiple Sclerosis 3. 5. 2022

News Mavacamten in the Treatment of HCM in Patients Referred for Septal Reduction

Extended 56-week follow-up of patients with hypertrophic cardiomyopathy (HCM) resistant to current pharmacotherapy in the VALOR-HCM study confirmed the lasting benefit of mavacamten –⁠ the first representative of a new class of selective reversible cardiac myosin inhibitors –⁠ as a new pharmacological treatment option reducing the need for invasive procedures.

Source: Hypertrophic Cardiomyopathy (HCM) 19. 2. 2024

News Telmisartan –⁠ antihypertensive with cardioprotective effects

Sartans are potent inhibitors of the AT1 receptor for angiotensin II widely used in the therapy of arterial hypertension. Given that chronic activation of the renin-angiotensin-aldosterone system (RAAS) plays an important role not only in the pathogenesis of arterial hypertension but also in the pathogenesis of atherosclerosis and the development of other cardiovascular diseases, the question arises whether the administration of sartans is associated with a broader cardioprotective effect. Telmisartan is the first representative of this group of antihypertensives for which a positive cardioprotective effect has been demonstrated.

Source: Sartans in the Treatment of Hypertension 24. 3. 2022

News Patient Evaluation of Durvalumab Treatment Results

The interim analysis results of the PACIFIC study, which monitored the efficacy of durvalumab in the treatment of locally advanced unresectable non-small cell lung cancer (NSCLC), demonstrated a significantly longer progression-free survival (PFS) with this treatment compared to placebo. The following work analyzed one of the secondary objectives of the PACIFIC study −⁠ patient-reported outcomes (PRO).

Source: Lung Cancer 31. 3. 2020

News Pilot Program for Lung Cancer Screening in the Czech Republic –⁠ Current Interim Results

Since January 1, 2022, a pilot population program for lung cancer screening has been underway in the Czech Republic. At the 7th PREVON conference in December 2023, updates on the progress as of March 31, 2023, were presented. Data for 2022 show a 4.4% detection rate of positive findings using low-dose CT in the targeted population of current or former smokers aged 55-74 years, who have so far undergone screening.

Source: Small Cell Lung Cancer 22. 4. 2024

News How Do Sleep and Depression Influence Each Other?

It is known that most patients with depression encounter some form of sleep disorder. In the following text, we briefly explore the complex relationship between depression and sleep and offer some practical recommendations that can help patients improve their sleep.

Source: Depression and Anxiety 27. 10. 2021

Články časopisu Adult-onset Still’s disease –⁠ a difficult path to diagnosis through fever and effusions of unknown origin

Author of the article: Jana Malegová, Lukáš Koten, Pavel Horák Source: Vnitřní lékařství | 5-6/2014 28. 6. 2014