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News ITP from the Patients' Perspective: How It Affects Their Lives and Which Needs They Find Unmet?
In recent years, new therapeutic options for immune thrombocytopenia (ITP) have been introduced, which are effective for many patients and have significantly improved their quality of life. However, it remains crucial to listen to patients' experiences with treatment and any unmet needs they may have. A meeting of the Platelet Disorder Support Association brought forth many interesting findings and shared experiences. So what troubles ITP patients the most?
News X-ray in Dentistry: Who Can Indicate and Who Can Perform?
X-ray is an integral and important part of dental diagnostics. However, since it is also a source of ionizing radiation, its use is subject to legislative regulations that govern it.
News Fexofenadine – Non-Sedative and Immunomodulatory Antihistamine in the Treatment of Allergic Symptoms
One of the biggest limitations of traditional antihistamines is the sedative effect on the central nervous system. Newer antihistamines do not cause sedation, are not associated with serious side effects, and some also have immunomodulatory effects.
News Pregabalin in Seniors Confirmed Its Safety and Effectiveness
A pooled analysis of 11 studies investigated the safety and effectiveness of pregabalin in seniors with neuropathic pain. Are the outcomes in these indicators different for older individuals than in the general population sample?
News Metamizole, even after 100 years on the market, remains an important component of postoperative pain therapy
Metamizole has been used in the therapy of a wide range of acute and chronic pains for 100 years. Thanks to a number of advantages, it still represents one of the most frequently used analgesics in daily clinical practice.
News Alopecia Areata – Autoimmune Inflammatory Disease and a New Targeted Treatment Option
Alopecia areata (AA) is one of the non-scarring focal alopecias. It is an autoimmune disease of the hair follicle, the etiopathogenesis of which is not entirely understood. At the hair root, a lymphocytic inflammatory infiltrate develops, resulting in follicle miniaturization and the growth of a thin dystrophic hair. Recently, however, a new strategy for the treatment of AA has emerged, focusing on reducing inflammation of the hair follicle by inhibiting Janus kinases (JAK). This is the first therapeutic modality officially approved for this indication.
News What a General Practitioner Needs to Know About Gliflozins
The revolutionary benefits of gliflozins have completely changed the perspective on the choice of pharmacotherapy for diabetes. They have attracted not only diabetologists but also cardiologists and nephrologists after the favorable effects of this group of drugs on heart failure and renal functions were demonstrated even in patients without diabetes. Dapagliflozin and empagliflozin were subsequently included in recommendations for the treatment of heart failure regardless of the presence of diabetes. Dapagliflozin has also been approved for the treatment of patients with chronic kidney disease.
News INFOGRAPHIC: LDL Cholesterol - Recommended Target Values
Elevated levels of LDL cholesterol are a significant risk factor for cardiovascular diseases, which remain the most common cause of death among adult Czechs. We have strong evidence about who and how LDL-c should be reduced, and ample treatment options to achieve this. Yet, more than half of the patients do not achieve the target LDL-c values. A useful tool for practice can be the 'risk traffic light' - an infographic clearly showing which risk category a patient falls into and what the recommended target LDL-c values are for each risk category. This makes it easier to plan tailor-made individual treatment.
News Epilepsy with Generalized Tonic-Clonic Seizures in an Adolescent Patient – A Case Study
This is the story of Anička, a 16-year-old girl who has been treated for epilepsy since she was 14. Her condition is accompanied by generalized tonic-clonic seizures, which may need to be managed acutely with rescue medication, either at home or at school. Instead of the previously used rectally administered diazepam, a new, safer and more comfortable option for rescue medication is now available: buccally administered midazolam. This modality may also help alleviate anxiety and other psychological impacts related to the condition, as illustrated by our case study.
News Diagnosis of Cow Milk Protein Allergy − Current Methods and Their Diagnostic Value
Cow milk protein allergy (CMPA) is among the most common pediatric food allergies. In case of early reaction, the child should be immediately referred to an allergist; for delayed symptoms, an elimination-exposure test can be performed under the guidance of a pediatrician.
News Substitution Treatment of von Willebrand Disease with vWF and FVIII Concentrates
Recently published recommendations from Poland regarding the diagnosis and treatment of von Willebrand disease (vWD) provide a comprehensive summary of the current approach to substitution therapy using concentrates containing von Willebrand factor (vWF) and coagulation factor VIII (FVIII), administered primarily during bleeding or surgical procedures.
News Revolutionary Change in the Paradigm of Multiple Sclerosis (MS) Treatment in the Czech Republic
At the beginning of last year, there was a revolutionary change in the paradigm of multiple sclerosis (MS) treatment in the Czech Republic. Patients with MS and an unfavorable prognosis no longer have to go through ineffective medications on their way to highly effective therapy (HET, High Efficacy Therapy), but can be treated with the highly effective drug Ocrevus® from the first symptoms of the disease.
News Expanded Vaccination Option Against Pneumococci Thanks to 15valent Vaccine
Our arsenal for preventing pneumococcal diseases has been expanded with a 15-valent conjugate vaccine that includes important serotypes causing invasive pneumococcal diseases (IPD). The following text briefly summarizes basic information not only about IPD, their prevention, diagnosis, and treatment, but especially about the management of vaccination with the 15-valent vaccine in practice.
News Can We Lump All Gabapentinoids Together?
General practitioners often encounter peripheral neuropathic pain in their practice. One of the primary modalities for treating both painful diabetic neuropathy and postherpetic neuralgia is gabapentinoids, specifically gabapentin and pregabalin. Are these substances completely interchangeable, or do their efficacy and practical application differ?
News Effect of PCSK9 Inhibitors on Clinical Outcomes in Patients with Hypercholesterolemia – Meta-Analysis of 35 Randomized Controlled Trials
The authors from several American institutions examined the efficacy and safety of two proprotein convertase subtilisin/kexin type 9 (PCSK9i) inhibitors, alirocumab and evolocumab, in their work. They conducted a systematic meta-analysis of randomized controlled clinical trials comparing the administration of these two PCSK9i with standard treatment.
News Intermittent Fasting May Carry Significant Health Risks
Results from an observational study presented at this year’s American Heart Association (AHA) Congress revealed surprising findings. Eating restricted to an 8-hour window daily—a popular form of intermittent fasting—may be associated with a significantly higher risk of cardiovascular (CV) death compared to regular eating within a 12–16-hour window.
News Treatment of Cough in Clinical Practice: Which Preparations Are Suitable and When?
In clinical practice, we differentiate the treatment of non-productive and moist productive cough. When choosing appropriate therapy, we consider the characteristics of the available medicinal products, such as sedation, route of administration, potentiation of antibiotic effect, or anti-inflammatory effect. Combining antitussive and expectorant in one dose is irrational in any case. So, how should one proceed in the treatment of cough correctly?
News Ocrelizumab in the Treatment of Multiple Sclerosis – 10-Year Data
Multiple sclerosis (MS) is a lifelong disease with a high risk of permanent disability. Current information on the long-term efficacy and safety of treatment is therefore absolutely essential for the optimal choice of therapeutic agent – in this case, ocrelizumab.