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News Another Positive Effect of Diosmin −⁠ Influence on Oxidative Stress

Diosmin is an established drug in the therapy of chronic venous insufficiency. It is known to act through several different mechanisms. A study by Polish authors provides evidence of its ability to reduce oxidative stress.

Source: Venous Insufficiency 11. 2. 2020

News Interchangeability of Diosmin and Micronized Purified Flavonoid Fraction

Among the medicinal products reimbursed for chronic venous disease, those containing micronized diosmin (Diozen 180 tbl.) have been newly included. Which substances are available for this indication, and what determined the interchangeability of micronized diosmin with micronized purified flavonoid fraction (MPFF) and other selected venotonics stabilizing capillaries?

Source: Venous Insufficiency 16. 9. 2022

News Current Treatment Options for Multiple Myeloma

Multiple myeloma (MM) accounts for about 10% of all hematologic malignancies. Thanks to advancements in diagnostic methods, it is now understood as a collection of several cytologically distinct plasma cell malignancies. Alongside progress in diagnostics, there has also been rapid development in therapy, significantly improving survival rates for this previously very unfavorable diagnosis, especially in the last 15 years.

Source: Hematologic Malignancies 10. 2. 2022

Články časopisu Von Willebrand disease

Author of the article: P. Smejkal Source: Transfuze a hematologie dnes | 2/2015 10. 5. 2015

News VIDEO: Antibiotic Treatment of Infections Caused by MDR Bacteria –⁠ Seminar Recording

Recording of a professional seminar on the topic of infections caused by MDR bacteria, which took place on November 2, 2021, at the Medical House in Prague.

Source: Anti-Infectives 11. 11. 2021

News Which Dietary Recommendations Actually Work for Irritable Bowel Syndrome?

Food is both a trigger for symptoms and a treatment tool for individuals with irritable bowel syndrome (IBS). A 2021 review summarizes the results of the latest research on the effectiveness of dietary measures for IBS and the evidence of which measures are truly beneficial. A positive impact was found for general healthy eating recommendations, soluble fiber supplementation, a low short-chain carbohydrate diet, and probiotic administration.

Source: Irritable Bowel Syndrome 13. 6. 2022

Články časopisu Periodic fevers and other autoinflammatory diseases

Author of the article: Šárka Fingerhutová, Eva Jančová, Markéta Tesařová, Lenka Dvořáková, Pavla Doležalová Source: Časopis lékařů českých | 3/2018 27. 6. 2018

News How Does Cenobamate Compare with Third-Generation Anti-Seizure Medications in Terms of Cost-Effectiveness?

The main goal of epilepsy treatment is to achieve seizure freedom without unacceptable side effects of therapy. Despite the benefits of the latest generation of anti-seizure medications (ASMs), approximately 40% of patients suffer from drug-resistant epilepsy. The recently approved cenobamate brings new hope to patients. A Spanish pharmacoeconomic study aimed to compare the cost-effectiveness of cenobamate with selected third-generation ASMs as adjunctive therapy in patients with drug-resistant focal epilepsy.

Source: Epilepsy 8. 6. 2023

News Cenobamate −⁠ A Case Study from Slovak Real Practice

Cenobamate is indicated for adjunctive therapy of focal seizures with or without secondary generalization in adult patients who have not achieved sufficient results with previous treatment with at least 2 antiepileptics. This new anti-seizure medication with a dual mechanism of action thus brings another therapeutic option for patients refractory to treatment. At the November 34th Slovak-Czech Epileptology Congress in Bratislava, during a symposium titled “Is there hope for a quality life with epilepsy?” doc. MUDr. Eva Feketeová, PhD., from the Neurological Clinic LF UPJŠ and UNLP in Košice shared her first experiences with cenobamate in clinical practice.

Source: Epilepsy 23. 12. 2022

News Negative Symptoms of Schizophrenia and Their Assessment

Schizophrenia is a serious psychiatric disorder with a prevalence of up to 1%. It can manifest with both negative and positive symptoms. We briefly summarize the clinical assessment and rating scales of negative symptoms in the following text.

Source: Schizophrenia and Antipsychotics 14. 7. 2021

News Kidney Carcinoma –⁠ Key Facts About the Disease With the Highest Incidence Worldwide in the Czech Republic

The incidence of renal carcinoma is increasing every year. About a quarter of the cases are still diagnosed in the metastatic stage, yet early treatment can save lives. Below, we briefly summarize data on the incidence, etiology, and risk factors of this malignant disease based on a literature review from 1945–2015. These findings may be significant for prevention and screening in high-risk individuals.

Source: Kidney Carcinoma 5. 11. 2021

Články časopisu Comorbidity of Migraine and Depression –⁠ a Meta-analysis

Author of the article: J. Kožený, C. Höschl, L. Tišanská Source: Česká a slovenská neurologie a neurochirurgie | 6/2013 13. 11. 2013

News Hypotension during treatment with sacubitril/valsartan: practical tips for prevention and management

Despite the undeniable benefits of sacubitril/valsartan in terms of morbidity and mortality in patients with chronic heart failure, its administration can be complicated by side effects. The most common of these is hypotension. Although it is an unpleasant complication, it does not –⁠ and should not –⁠ always be a reason to discontinue therapy. Fear of hypotension should not lead to not prescribing sacubitril/valsartan at all. We provide practical guidance on how to approach this clinical situation.

Source: Chronic Heart Failure and Lipidology 27. 11. 2020

News Regorafenib and Trifluridine/Tipiracil: Hospitalization and Clinical Outcomes in the Treatment of Metastatic Colorectal Cancer

Regorafenib and trifluridine/tipiracil are drugs that prolong overall survival (OS) in pre-treated patients with metastatic colorectal cancer (mCRC). The difference in the toxicity of these agents led to the hypothesis that treatment toxicity of individual drugs might increase the number of hospitalizations, thereby affecting patients' quality of life. The study presented below aimed to analyze the number of hospitalizations during treatment and their possible impact on OS.

Source: Treatment of Gastrointestinal Carcinomas 22. 3. 2021

News Ocrelizumab in the Treatment of Multiple Sclerosis –⁠ 10-Year Data

Multiple sclerosis (MS) is a lifelong disease with a high risk of permanent disability. Current information on the long-term efficacy and safety of treatment is therefore absolutely essential for the optimal choice of therapeutic agent –⁠ in this case, ocrelizumab.

Source: Neurology - Multiple Sclerosis 20. 2. 2024