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News What FVIII Levels Are Ideal for Preventing Bleeding in Hemophilia A?

Recent studies indicate that target trough levels of factor 1–3% during prophylactic treatment are insufficient to fully prevent clinical and subclinical bleeding. With a sustained FVIII level > 15%, as shown in studies with mild hemophiliacs, spontaneous bleeding is very rare. This raises the question of whether achieving zero bleeding incidence with FVIII replacement therapy is possible and whether it can be a realistic goal. This topic was also explored in a presentation by Dr. Ester Zápotocká from the Clinic of Pediatric Hematology and Oncology, 2nd Faculty of Medicine, Charles University and Motol University Hospital in Prague.

Source: Hemophilia 10. 5. 2021

News Combined Hormonal Contraception in the Treatment of Dysmenorrhea

Dysmenorrhea troubles many women of reproductive age and can deteriorate their quality of life, making it important for doctors to offer suitable therapy. We summarize the findings of research on the use of hormonal contraception containing drospirenone (DRSP) and ethinylestradiol (EE) in the treatment of dysmenorrhea.

Source: Oral Contraception 15. 3. 2022

News Case Study with Voting: Intensification of Type 2 Diabetes Therapy in a Chronically Treated Patient. How to Proceed According to Current Recommendations?

We have prepared an interactive case study for you with a 70-year-old patient with decompensated Type 2 Diabetes. The patient was diagnosed with DM eight years ago. What treatment approach would you choose? And why? And how should you correctly proceed according to the current recommendations of SVL? Watch a short video with us.

Source: Diabetes 12. 11. 2020

Články časopisu Type 2 diabetes mellitus and bone quality

Author of the article: MUDr. Raška Ivan, Ph.D. Source: Clinical Osteology | 3/2018 14. 5. 2019

News Overview of the Efficacy of the Fixed Combination Aclidinium-Bromide/Formoterol-Fumarate in the Maintenance Treatment of COPD

Fixed combination inhalation medications have become the cornerstone of pharmacotherapy for moderate to severe chronic obstructive pulmonary disease (COPD). American authors have published an overview of study results evaluating the efficacy and safety of one of the newest fixed combinations of LABA/LAMA, aclidinium-bromide and formoterol-fumarate (AB/FF), in the maintenance treatment of COPD compared to placebo or other medications. These clinical studies investigated the extent to which regular use of this fixed combination alleviates COPD symptoms, improves lung function, reduces the incidence of exacerbations, and increases exercise tolerance.

Source: Treatment of Asthma and COPD 30. 8. 2022

Články časopisu Novel molecules used in the targeted treatment of acute myeloid leukaemia –⁠ adverse reactions, treatment complications and signifi cant drug interactions

Author of the article: J. Vedrová, Z. Ráčil Source: Transfuze a hematologie dnes | 1/2021 15. 3. 2021

News 48 Tablets of Teriflunomide? Nothing Should Be Overdone! −⁠ Case Study

A case study published in the Journal of Clinical Pharmacy and Therapeutics describes an overdose of teriflunomide, specifically the ingestion of 672 mg of this drug. What measures did the doctors take with the patient? And were they able to prevent serious consequences?

Source: Multiple Sclerosis 15. 8. 2023

Články časopisu The EMPRISE study (Real World Evidence): empagliflozin is reducing number of hospitalizations for heart failure, even in patients without cardiovascular disease

Author of the article: Emil Martinka Source: Forum Diabetologicum | 3/2019 18. 12. 2019

Články časopisu Extrahepatic bile duct malignancies

Author of the article: V. Třeška, J. Fichtl, J. Ferda, J. Fínek, T. Skalický, V. Liška, P. Hošek Source: Rozhledy v chirurgii | 9/2022 17. 10. 2022

News Effect of Extended-Release Metformin on Cognitive Functions in Older Frail Women with Diabetes and Hypertension

Women have a higher risk of geriatric frailty regardless of age and menopausal status. This risk further increases with the presence of diabetes and hypertension, which also elevate the risk of cognitive dysfunction. According to available data, metformin may reduce the risk of developing frailty in postmenopausal women. A recently published Italian study, LEOPARDESS, aimed to evaluate the effect of extended-release metformin on the cognitive functions of this population of women.

Source: Cardiovascular Risks 14. 3. 2024

News Inflammation, Polyunsaturated Fatty Acids and Their Significance in the Development and Treatment of Depression

Depression is currently a highly discussed disease with a prevalence that is likely to rise. Therefore, scientists are focusing on potential causes and new treatment modalities. It has been shown that inflammation, which can be influenced by polyunsaturated fatty acids, likely plays a role in the development of the disease. Inflammation is also a possible explanation for the frequent coexistence of depression and metabolic syndrome.

Source: Depression and Anxiety 19. 7. 2020

News Efficacy and Safety of Enoxaparin as Bridging Anticoagulant Therapy After Ventricular Assist Device Implantation

The implantation of a ventricular assist device has become an increasingly common method in the treatment of end-stage heart failure in recent years. The implantation of the device necessitates anticoagulant therapy. In the long term, warfarin is most often used according to guidelines, but there are no clear recommendations for early postoperative anticoagulant therapy. The aim of a clinical study published last year was to evaluate the efficacy and safety of enoxaparin as bridging anticoagulant therapy after device implantation within a 3-month postoperative period.

Source: Thromboprophylaxis 1. 10. 2021

Články časopisu A Rear Cause of Blindness in a Patient with Nasal Polyposis. Leber’s Hereditary Optic Atrophy of Visual Nerve

Author of the article: P. Bruthansová, J. Vokurka, P. Diblík, D. Dočekalová, E. Rozsypalová, J. Zeman, J. Plzák Source: Otorinolaryngologie a foniatrie | 3/2011 6. 10. 2011

News Drops with Liposomal Ozonized Oil Reduce Ocular Microbial Burden Before Cataract Surgery

The periocular zone and conjunctiva are characterized by high microbial activity. Therefore, it is important to reduce this bacterial burden as part of preoperative prophylaxis before surgery to minimize the risk of infection. The aim of the study presented below, conducted in 20 Italian centers, was to evaluate the antimicrobial efficacy of a new ocular solution in patients undergoing cataract surgery.

Source: Treatment of Glaucoma 14. 11. 2023

Články časopisu Systemic inflammatory response with high CRP values as the dominant symptom of multiple myeloma

Author of the article: Zdeněk Král, Zdeněk Adam, František Folber, Mojmír Moulis, Miroslav Tomíška, Lucie Říhová, Martin Štork, Alena Buliková, Luděk Pour, Marta Krejčí, Viera Sandecká, Renata Koukalová, Zdeněk Řehák, Zdeňka Čermáková Source: Vnitřní lékařství | 1/2019 20. 2. 2019