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News Inflammation, Polyunsaturated Fatty Acids and Their Significance in the Development and Treatment of Depression

Depression is currently a highly discussed disease with a prevalence that is likely to rise. Therefore, scientists are focusing on potential causes and new treatment modalities. It has been shown that inflammation, which can be influenced by polyunsaturated fatty acids, likely plays a role in the development of the disease. Inflammation is also a possible explanation for the frequent coexistence of depression and metabolic syndrome.

Source: Depression and Anxiety 19. 7. 2020

News Efficacy and Safety of Enoxaparin as Bridging Anticoagulant Therapy After Ventricular Assist Device Implantation

The implantation of a ventricular assist device has become an increasingly common method in the treatment of end-stage heart failure in recent years. The implantation of the device necessitates anticoagulant therapy. In the long term, warfarin is most often used according to guidelines, but there are no clear recommendations for early postoperative anticoagulant therapy. The aim of a clinical study published last year was to evaluate the efficacy and safety of enoxaparin as bridging anticoagulant therapy after device implantation within a 3-month postoperative period.

Source: Thromboprophylaxis 1. 10. 2021

Články časopisu A Rear Cause of Blindness in a Patient with Nasal Polyposis. Leber’s Hereditary Optic Atrophy of Visual Nerve

Author of the article: P. Bruthansová, J. Vokurka, P. Diblík, D. Dočekalová, E. Rozsypalová, J. Zeman, J. Plzák Source: Otorinolaryngologie a foniatrie | 3/2011 6. 10. 2011

News Drops with Liposomal Ozonized Oil Reduce Ocular Microbial Burden Before Cataract Surgery

The periocular zone and conjunctiva are characterized by high microbial activity. Therefore, it is important to reduce this bacterial burden as part of preoperative prophylaxis before surgery to minimize the risk of infection. The aim of the study presented below, conducted in 20 Italian centers, was to evaluate the antimicrobial efficacy of a new ocular solution in patients undergoing cataract surgery.

Source: Treatment of Glaucoma 14. 11. 2023

News Von Willebrand Disease in Women

Even in the context of gynecological issues, it is sometimes necessary to consider a hematological etiology of difficulties. The recommendations of the American College of Obstetricians and Gynecologists (ACOG) in this context focus on the possible connections with von Willebrand disease.

Source: Von Willebrand Disease 23. 11. 2021

News News in COPD Treatment Recommendations in a Nutshell

We present an overview of the most important changes in the annually updated recommendations of the Global Initiative for Chronic Obstructive Lung Disease (GOLD).

Source: Treatment of Asthma and COPD 6. 4. 2022

News Nutritional Care as Part of Prehabilitation in Surgical Patients

Nutritional preparation of patients before surgery as part of prehabilitation can significantly affect the quality of recovery and physical condition of patients after surgery. This topic is highlighted, among other sources, by a team of Canadian doctors in their work published in the journal Anesthesiology, an interesting meta-analysis of 15 RCTs, and last but not least, it is covered in a webinar titled 'Surgical Patient and Nutrition'.

Source: Enteral Nutrition 14. 10. 2020

News Why can probiotics and vitamin D significantly affect human health?

Vitamin D deficiency is the most common hypovitaminosis in developed countries. It is largely related to a lack of outdoor activity. Additionally, the typical Western diet does not support a healthy composition of the gut microbiome. Gut dysbiosis, in turn, is associated with both intestinal and systemic diseases. Alongside a healthy lifestyle, probiotics and oral vitamin D supplementation offer solutions.

Source: GI, colic and microbiome 15. 3. 2022

News Frequent Nausea During Chemotherapy Despite Antiemetic Prophylaxis

Current clinical research has focused on vomiting as a primary issue in the occurrence of CINV (chemotherapy-induced nausea and vomiting) and, using recommended antiemetic prophylaxis, this problem has been relatively well managed. However, the incidence and impact of nausea are underreported. We present the results of an observational study that evaluated the incidence of nausea in patients undergoing chemotherapy.

Source: Antiemetic Therapy 9. 12. 2020

News Rapid Strengthening and Long-term Stabilization –⁠ New Strategy for Sequential Treatment of Severe Osteoporosis

Osteoanabolics have long been considered a treatment modality for osteoporosis that is only considered when antiresorptive medication lacks the desired efficacy. However, their role has been shifting in recent years based on new findings from clinical research, as evidenced by the conclusions of the expert working group of the European Society for Clinical and Economic Aspects of Osteoporosis, Osteoarthritis, and Musculoskeletal Diseases (ESCEO), whose brief summary we bring.

Source: Osteoporosis – Trends in Sequential Therapy 27. 9. 2023

News Alzheimer's Disease –⁠ Another Pandemic on the Horizon?

Due to the COVID-19 pandemic, other current problems often get pushed into the background. One of these is the aging population and the increasing prevalence of dementia. The key question thus becomes how to extend the period of active aging as much as possible.

Source: Cognitive in the treatment of Alzheimer's disease 11. 2. 2022

News Current Position of Venetoclax in the Treatment of AML −⁠ Hope for a Better Prognosis?

The treatment of acute myeloid leukemia (AML) remained stagnant for a long time, with many new drugs emerging only in the past few years. One of the newest and most important is the Bcl-2 anti-apoptotic protein inhibitor venetoclax.

Source: Acute Myeloid Leukemia 27. 2. 2023

News Micronized Diosmin Obtained Reimbursement, Based on Its Therapeutic Interchangeability with MPFF

On January 11, 2022, the State Institute for Drug Control (SÚKL) issued a decision on the determination of the amount and conditions of reimbursement from health insurance for a drug containing micronized diosmin. The reimbursement is valid from March 1, 2022.

Source: Venous Insufficiency 28. 2. 2022

News Stable Position of Micronized Diosmin in the Treatment of Chronic Venous Insufficiency and Hemorrhoids

Diosmin is a flavonoid used in Europe as a venotonic and vasoprotective agent for over 40 years. Significant progress has been made in medicine during this time, yet the role of diosmin in the treatment of venous insufficiency and hemorrhoidal disease remains important. Diosmin itself has also evolved, being micronized for better biological availability and showing significant effects on the vascular system according to research.

Source: Venous Insufficiency 30. 9. 2020

News Diosmin and its application in the treatment of venous insufficiency

A number of procedures, including pharmacotherapy, are used in the treatment of chronic venous insufficiency, in which diosmin, for example, is applied. The report by pharmacologist MUDr. Jiří Slíva, Ph.D., summarizes the mechanism of action and pharmacological properties of this substance.

Source: Venous Insufficiency 27. 3. 2020