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News Efficacy and Safety of Single-Application Hyaluronic Acid in Osteoarthritis Therapy
Causal therapy for osteoarthritis does not yet exist. Patients suffering from progressive joint disease are thus dependent on symptomatic medications that alleviate symptoms and partially slow the progression of osteoarthritis. An essential role in therapy is played by viscosupplementation in the form of intra-articular application of hyaluronic acid (HA). Currently, 3rd generation preparations intended for single application are preferred due to their efficiency and safety.
News SCOPE 2021 – State of Osteoporosis and Its Treatment in European Countries
The SCOPE 2021 project (The Scorecard for Osteoporosis in Europe) by the International Osteoporosis Foundation (IOF) gathered and tabulated data from 29 European countries on the burden of osteoporosis, the quality and availability of services related to the diagnosis and treatment of this disease, and the use of these services in individual states. Within the significantly heterogeneous results, the Czech Republic did not fare very well.
News Expression of PD-L1 as a Predictive Biomarker for Therapy Selection in mRCC
A newly published systematic review and meta-analysis of studies involving patients with metastatic renal cell carcinoma (mRCC) evaluates the predictive significance of PD-L1 expression in the treatment with immune checkpoint inhibitors.
News Current Reimbursement Conditions for the Dual Inhibitor IL-4/IL-13 Dupilumab
The biologic dupilumab is approved for the treatment of several diseases with type 2 inflammation. What is the current reimbursement situation in key indications? We summarize in the following brief overview.
News Experiences with the Treatment of Coagulopathy in Obstetrics – ROTEM-Guided Algorithm
An observational study from a hospital in Liverpool, UK, was published in the journal Anaesthesia, where they implemented a bleeding management algorithm for obstetric procedures based on rotational thromboelastometry (ROTEM) testing. After 4 years of using this algorithm, it was found that selective administration of fibrinogen concentrates based on ROTEM results led to better clinical outcomes in the treatment of coagulopathy.
News Doc. Jitka Fricová: The biggest challenge remains the patient with unbearable chronic pain
Research findings are pushing the boundaries of optimal chronic pain treatment, including better prevention and reduced side effects of analgesics. Algological care is readily accessible in the Czech Republic, yet it faces limitations, such as the less manageable nature of unbearable pain, particularly neuropathic or oncologic. We briefly discuss the topic with the head physician of the Pain Treatment Center at the Department of Anesthesiology, Resuscitation, and Intensive Care Medicine, First Faculty of Medicine, Charles University, and General University Hospital in Prague, Doc. MUDr. Jitka Fricová, Ph.D.
News Subclinical Hypothyroidism Associated with the Use of Allopurinol? What the Results of a Large Multicenter Study Suggested
Allopurinol is a widely used drug for the treatment of hyperuricemia and gout. The retrospective study presented below investigated whether its long-term use is associated with an increased risk of developing subclinical hypothyroidism.
News Effect of Short-Term and Long-Term Stress on Heart Rate Variability
Acute and chronic stress significantly affects the cardiovascular (CV) system. The study presented below examines the effects of both acute and chronic stress on heart rate variability in 50 healthy individuals.
News Targeted Treatment of Metastatic Breast Cancer in the 2nd Line – Experiences from Practice
The recommended treatment for metastatic HER2-positive breast cancer in the 1st line involves dual blockade of the HER2 signaling pathway using trastuzumab and pertuzumab in combination with a taxane cytostatic. After the failure of this therapy, treatment with trastuzumab emtansine (T-DM1) is recommended. However, this recommendation is not supported by a prospectively designed controlled study examining the outcomes of this therapeutic sequence. Therefore, a group of Italian authors decided to publish the results of a patient cohort treated with this sequence in real clinical practice conditions.
News Effect of 3 Different Doses of Trazodone on QT Interval Length
Patients diagnosed with depression often also suffer from cardiovascular diseases, including heart failure. Given the increased risk of death in such comorbid patients, the safety and efficacy of the antidepressant must be considered when choosing one.
News Frequency of Mutations in Genes Predisposing to Ovarian Cancer in the Czech Population
The authors of a Czech study evaluating the occurrence of mutations in tumor-predisposing genes for ovarian cancer hypothesized that if their occurrence in patients with this diagnosis was significant, identifying carriers of these mutations could help reduce the prevalence and mortality of this disease given the absence of other screening tools.
News Thanks to Buccolam, the reality of suppressing convulsive seizures in children and adolescents approaches parents' ideal management
What crosses the mind of a parent when they notice their epileptic child or adolescent is having a convulsive seizure? They want it to be over quickly and safely. What constitutes the integral part that makes this wish a reality? And how does the newest treatment modality, buccally administered midazolam (Buccolam), address these needs?
News Human Papillomavirus in Adults – HPV Does Not Choose Gender
A significant part of the population is exposed to human papillomaviruses (HPV) throughout their lives. In recent years, there has been a global effort to increase vaccination coverage not only among children and adolescents who have not yet been vaccinated but also among adult women and men who could benefit from it, including those who have likely already encountered HPV.
News Comparison of Duloxetine, Gabapentin, and Pregabalin in the Treatment of Diabetic Neuropathic Pain
Painful diabetic neuropathy represents an unpleasant complication of diabetes, in which several groups of drugs are used in therapy. Among their representatives are duloxetine, gabapentin, and pregabalin. The meta-analysis, whose conclusions we summarize below, focused on comparing their effectiveness and tolerability.
News Interchangeability of Diosmin and Micronized Purified Flavonoid Fraction
Among the medicinal products reimbursed for chronic venous disease, those containing micronized diosmin (Diozen 180 tbl.) have been newly included. Which substances are available for this indication, and what determined the interchangeability of micronized diosmin with micronized purified flavonoid fraction (MPFF) and other selected venotonics stabilizing capillaries?
News Interstitial Lung Processes and Their Fibrotic Progression
Interstitial lung processes (ILPs) include more than 200 clinical units that share diffuse involvement of lung tissue and thus have similar clinical, radiological, and functional findings. However, their broad differential diagnosis is particularly problematic.
News Options for Systemic Therapy of Advanced Stage Small Cell Lung Cancer
Small cell lung cancer (SCLC) is the most aggressive type of lung tumor. Although it responds well to chemotherapy and radiotherapy, due to the early onset of treatment resistance, the 5-year survival rate is less than 10%. After more than 30 years of very limited progress in treating advanced SCLC patients, immune checkpoint inhibitors (checkpoints) have been introduced to the market, significantly prolonging survival. What are the current recommendations for treating patients with advanced SCLC?
News Doc. Miloslav Salavec: We Still Encounter Delayed Initiation of Biological Treatment in AD and Many Other Diagnoses
Not all patients with atopic dermatitis (AD) who are indicated for biological treatment with dupilumab manage to reach centers where the treatment is provided. It's even more unfortunate when there's ample evidence that the effects of this therapy on disease manifestations and overall quality of life extend beyond just the patients. It also impacts the lives of their close ones who care for those with atopic dermatitis. Head of the Clinic of Venereal and Skin Diseases at Charles University and the University Hospital Hradec Králové Doc. MUDr. Miloslav Salavec, CSc., evaluates how dupilumab has performed over several years of real clinical practice and the specific benefits it has brought to patients.
News Wireless Smart Devices Monitor Health by Detecting Sounds
The human body continuously emits various forms of acoustic-mechanical signals that can provide important information about its health. Researchers from Northwestern University in the USA have developed miniature wearable devices (wearables) capable of simultaneously detecting sounds from multiple locations on the body, thereby continuously monitoring the health of the wearer. In a pilot project, the devices were tested on prematurely born infants with breathing and intestinal motility disorders and on adults with chronic lung diseases.
News Hope Awakens with Early Diagnosis of Parkinson's Disease Based on Skin Odor
According to scientists from the United Kingdom, a simple test based on an individual's skin odor could aid the early diagnosis of Parkinson's disease. A study has already been launched to investigate the chemicals secreted by the skin of patients with Parkinson's disease.
News News in Laboratory Diagnostics of Early Sepsis − First Czech Experiences
Sepsis represents one of the most frequent causes of morbidity and mortality in critically ill patients. Laboratory markers play an important role in the diagnosis and prognosis of septic states. The aim of the study by the Czech authors was to evaluate the diagnostic yield of new laboratory markers in the form of monocyte distribution width and specific markers on the surface of neutrophil granulocytes.
News Natural Doesn’t Always Mean Better – How to Deal with the Appeal to Nature in the Doctor’s Office
"Herbs rather than chemicals." Doctors are hearing similar statements more and more often. This attitude reflects the so-called appeal to nature – a logical fallacy based on the assumption that natural means better and safer. In academic literature, this type of thinking is more broadly referred to as the naturalistic fallacy. Such reasoning significantly influences not only patients’ decisions but often also those of healthcare professionals themselves.
News STADA Brings Innovative Drug for Treatment of Advanced Parkinson's Disease to Czech Republic
STADA PHARMA CZ is introducing a new system for continuous delivery of 3 active substances for the treatment of advanced stages of Parkinson's disease (PD) to the Czech market. It is one of the major innovations in the care of PD patients in the last two decades. The drug, which STADA acquired the rights to in 2020, had already been introduced in the Nordic countries where this treatment is successfully underway. In the Czech Republic, it has been fully covered since April 1, 2022.