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News Current View on the Issue of Protein Intake in Critically Ill Patients

A summary of current knowledge and guidelines concerning the nutritional needs of critically ill patients presented last year in the journal Clinical Nutrition deals with protein intake, specifically its optimal amount, risks of incorrect approaches to protein administration, and methods for assessing the nutritional status of patients in intensive care units.

Source: Parenteral Nutrition 5. 5. 2022

Články časopisu Pelvic Injury from the Urogyneacology Point of View. Overview

Author of the article: F. Hron, V. Džupa, M. Otčenášek, J. Feyereisl, R. Grill Source: Rozhledy v chirurgii | 11/2010 3. 11. 2010

News Electronic Cigarettes as an Alternative Option for Quitting Smoking?

Diseases caused by smoking tobacco products are a significant cause of global morbidity and mortality. One of the options for quitting smoking is electronic cigarettes, which, although not entirely researched yet, according to available studies, genuinely help people quit smoking and are associated with significantly lower health risks compared to traditional tobacco products.

Source: MDT Board 12. 1. 2023

News Does adding statins to DOACs reduce the risk of major bleeding in patients with non-valvular atrial fibrillation?

A large retrospective study, the results of which were recently published, investigated to what extent the concurrent administration of statins is associated with a lower risk of major bleeding, including intracranial and gastrointestinal bleeding, in patients with non-valvular atrial fibrillation taking direct oral anticoagulants (DOACs).

Source: Anticoagulant Treatment 1. 11. 2022

News Assessment of Infection Risk in Patients with Multiple Sclerosis Treated with Various DMDs

Although the increased risk of infections with some disease-modifying drugs (DMDs) is known, we still lack sufficient real-world clinical data to evaluate and compare the risk levels of individual drugs. A Swedish study therefore provides information about these risks with glatiramer acetate, beta interferon, natalizumab, fingolimod, and rituximab in the treatment of multiple sclerosis (MS).

Source: Multiple Sclerosis 3. 3. 2020

News Smouldering Multiple Sclerosis: How Can MRI Help in Its Identification?

With the changing understanding of the etiopathogenesis of multiple sclerosis, several new questions arise. One of them is the question of identifying the progressive phase of the disease. Can magnetic resonance imaging (MRI) help in this regard?

Source: Multiple Sclerosis 4. 1. 2023

Články časopisu Prevention of the invasion of malignant cells of gynecologic tumors during surgery

Author of the article: J. Kobilková, J. E. Jirásek, J. Jedličková, O. Benešová, J. Mašata Source: Česká gynekologie | 6/2010 20. 12. 2010

News Patient Treated with Nivolumab After Previous Failure of BRAF Inhibitor Therapy

Source: Case Studies from Immunooncology 11. 9. 2020

News Post-COVID Depression: How Can a General Practitioner Help?

Psychiatrists confirm that mental health plays an increasingly important role in the context of the COVID-19 pandemic. Although exact data will only be available over time, as the impacts in this regard will undoubtedly be long-term, it is already necessary to recognize the correlations between the psyche, the pathophysiology of COVID-19, and the pandemic state of society. What should we be prepared for in the general practitioner's office in this regard, and what therapy is a suitable choice?

Source: Depression and Anxiety 30. 3. 2021

News How do IL-17 and IL-23 inhibitors fare in the treatment of psoriasis in direct comparison?

A recent study published in the British Journal of Dermatology is only the second paper to provide a direct comparison of the efficacy and onset speed of treatment with IL-17 and IL-23 inhibitors in patients with moderate to severe plaque psoriasis. The authors monitored the early response to treatment (at week 12), and the efficacy and safety of ixekizumab and guselkumab.

Source: Biological Treatment 3. 4. 2020

News Thromboprophylaxis as a Common Part of Care for At-Risk Patients Requiring Hospitalization: Yes or No?

The proportion of patients requiring hospitalization who are at high risk of developing thromboembolic disease is relatively high. However, not all of these patients have this risk identified and thromboprophylaxis initiated.

Source: Thromboprophylaxis 28. 5. 2021

News What are the patients' needs during acute phase schizophrenia therapy and how to increase their adherence?

Treatment of an acute episode of schizophrenia usually requires hospitalization in a psychiatric ward. Even though hospitalization causes discomfort and represents a burden for many patients, it enables quick and relatively precise diagnosis and timely initiation of adequate treatment and monitoring of its effectiveness. Recommended practices guide how to conduct such diagnostics and therapy. One of the symposiums at the 65th Czech-Slovak Psychopharmacological Conference, which took place in mid-January 2023 in Mariánské Lázně, also focused on the management of care for these patients during the first days of hospitalization and after discharge from acute inpatient care.

Source: Modern Treatment of Schizophrenia 21. 2. 2023

News Longer survival without liver transplant in patients with PBC treated with OCA?

Obeticholic acid (OCA) is a second-line treatment for patients with primary biliary cholangitis (PBC) who have an inadequate response to ursodeoxycholic acid (UDCA) or intolerance to it. The study presented below, the results of which were recently published, examined the effectiveness of OCA in reducing cholestatic enzymes as well as the length of survival without liver transplant in patients with PBC.

Source: Primary Biliary Cholangitis 20. 3. 2023

News Interaction of the 'Big Five' Helps Predict Depression

Experts refer to the 'Big Five' as a personality model that encompasses the following five dimensions: openness to experience, conscientiousness, extraversion, agreeableness, and neuroticism. Can this model be helpful in diagnosing depression?

Source: Depression and Anxiety 5. 10. 2020

News Update of International Recommendations for the Diagnosis and Treatment of Hereditary Angioedema from 2021

The aim of the 2021 update of the recommendations for the diagnosis and treatment of hereditary angioedema (HAE) is to help doctors answer important clinical questions: How to diagnose HAE? When and what prophylactic treatment to administer? What are the treatment goals? How do treatment of children and pregnant women differ? How to monitor disease activity, its impact, and control?

Source: Hereditary Angioedema 18. 5. 2022