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News MUDr. Petra Garnolová: The combination of medical cannabis with other analgesics is the ideal way to achieve the best effect with the fewest side effects
Medical cannabis is gradually finding its way to many patients with various ailments, including those with unmanageable and hard-to-influence chronic pain. For them, this therapy can offer a new chance at a quality life despite severe or terminal illness. A relatively new form that brings additional benefits is the extract of medical cannabis. We spoke with MUDr. Petra Garnolová, a specialist in clinical oncology and palliative medicine, about why it is worth considering not only as part of analgesic therapy and her experiences from real practice.
Journal articles Transcranial sonography of the medial temporal lobe in Alzheimer’s disease patients
News Doc. Jiří Kubeš: The major benefit of proton therapy lies in protecting healthy tissues
Nearly 9,000 patients with oncological diseases have already undergone modern proton radiotherapy at the Proton Center in Prague. Which diagnoses are suitable for this treatment modality, what are its main benefits, and what is its place in the comprehensive therapy of malignant tumors? We discuss these topics with the chief physician of this medical facility, Doc. MUDr. Jiří Kubeš, Ph.D.
News Does Beta-Blocker Therapy Reduce the Cardiovascular Benefit of Aerobic Exercise in Patients with Arterial Hypertension?
Regular aerobic exercise is generally recommended for patients suffering from arterial hypertension to reduce blood pressure values, improve physical fitness, and other parameters. The intensity of exercise is most often derived from the target heart rate, which is pharmacologically influenced in patients on beta-blockers. The question, therefore, is whether aerobic exercise brings the same cardiovascular benefit to this group of patients as it does to those not taking beta-blockers.
News Carpal Tunnel Syndrome as a Warning Sign of Cardiomyopathy Caused by Transthyretin Amyloidosis
Recent study results suggest that transthyretin amyloidosis is a more common cause of heart failure than previously thought. Early diagnosis and subsequent therapy are key to improving patient prognosis. A comprehensive study evaluating data from the Danish population registry suggests that carpal tunnel syndrome may be one of the initial symptoms of the disease.
News Bilastine as a reliable helper in the treatment of allergic rhinoconjunctivitis and urticaria even in younger children
Until recently, bilastine was indicated for the treatment of allergic rhinoconjunctivitis and urticaria only in patients over 12 years of age. However, current findings from valid studies demonstrate the safety and efficacy of its use even in younger individuals.
News When and why to consider the diagnosis of myasthenia gravis in neurological practice, and what treatment options do we currently have?
Myasthenia gravis (MG) is a clinically heterogeneous disease characterized by fluctuating muscle weakness and fatigability that worsens after physical exertion or mental stress. Accurate diagnosis is essential because treatment can lead to permanent remission and full functional capacity of the patient.
News STADA Brings Innovative Drug for Treatment of Advanced Parkinson's Disease to Czech Republic
STADA PHARMA CZ is introducing a new system for continuous delivery of 3 active substances for the treatment of advanced stages of Parkinson's disease (PD) to the Czech market. It is one of the major innovations in the care of PD patients in the last two decades. The drug, which STADA acquired the rights to in 2020, had already been introduced in the Nordic countries where this treatment is successfully underway. In the Czech Republic, it has been fully covered since April 1, 2022.
News Proton radiotherapy means lower risk with high efficacy of radiation. The key is getting the patient into the treatment process as soon as possible
The Proton Therapy Center in Prague (PTC − Proton Therapy Center Czech) is a modern healthcare facility specializing in the treatment of oncological diseases using so-called proton radiotherapy. This therapy is covered by public health insurance in indicated cases. Since its opening in 2012, PTC has treated nearly 10,000 patients, not only from the Czech Republic and Slovakia. In 2019, it became part of the National Oncology Center.
News How can inosine pranobex help with viral infections?
Inosine pranobex has long been used for its immunomodulatory and antiviral effects in the prophylaxis and therapy of various viral infections. Below we summarize its mechanism of action, indications, usage, and side effects.
News Thrombocytopenia Following mRNA Vaccination Against SARS-CoV-2
In connection with the administration of mRNA-based vaccines against the SARS-CoV-2 coronavirus, cases of secondary immune thrombocytopenia (ITP) have been described. A commentary published by a large team of authors in the American Journal of Hematology described a series of cases of low platelet counts identified within 2 weeks of vaccination. The data was obtained from the Centers for Disease Control and Prevention (CDC), the Food and Drug Administration (FDA), the Department of Health and Human Services (HHS), and the Vaccine Adverse Event Reporting System (VAERS), as well as through direct communication with patients and their physicians.
News Lurasidone in a Patient with Paranoid Schizophrenia and Asperger's Syndrome – A Case Study
Lurasidone is an effective and very gentle antipsychotic which is establishing a prominent position in modern psychopharmacotherapy. Its unique receptor profile makes it a suitable choice for hyperprolactinemia induced by risperidone. A significant benefit of lurasidone is its favorable cardiometabolic profile. Switching from another antipsychotic to lurasidone can be performed on an outpatient basis. Most importantly, it is essential to highlight its effect on both positive and negative symptoms of schizophrenia, as demonstrated by the presented case study.
News Can the use of sartans reduce mortality and severity of COVID-19 in hypertensives?
Existing scientific and clinical evidence suggests the involvement of the renin-angiotensin-aldosterone system (RAAS) in the pathophysiology of COVID-19. Some of the initial experimental therapy proposals included various interventions in the RAAS.
News Current Reimbursement Conditions for the Dual Inhibitor IL-4/IL-13 Dupilumab
The biologic dupilumab is approved for the treatment of several diseases with type 2 inflammation. What is the current reimbursement situation in key indications? We summarize in the following brief overview.
News High-Dose Cyclophosphamide in Hard-to-Treat Patients with B-NHL
For hard-to-treat patients with non-Hodgkin lymphoma, cyclophosphamide administered in one or two cycles can help bridge the period needed to obtain other effective treatments, as inferred from the work of French authors recently published in the European Journal of Haematology.
News Effect of Extended-Release Metformin on Cognitive Functions in Older Frail Women with Diabetes and Hypertension
Women have a higher risk of geriatric frailty regardless of age and menopausal status. This risk further increases with the presence of diabetes and hypertension, which also elevate the risk of cognitive dysfunction. According to available data, metformin may reduce the risk of developing frailty in postmenopausal women. A recently published Italian study, LEOPARDESS, aimed to evaluate the effect of extended-release metformin on the cognitive functions of this population of women.
News Comprehensive View on Care for Patients with Urostomy
Thanks to improvements in surgical techniques and shorter hospital stays, patients with a stoma are returning to their home environment and to the care of outpatient doctors sooner. Quality care in the postoperative period is a crucial element in the prevention of complications, support of healing, and education of ostomy patients. Doctors caring for these patients should approach them comprehensively, considering all their needs and aspects.