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News Maintenance treatment with oral olaparib in women with BRCA1/2 mutation and relapsed ovarian cancer

In a phase III study published in the journal Lancet Oncology, data on the effectiveness of olaparib in patients with ovarian cancer and BRCA1/2 mutation were evaluated. The poly(ADP-ribose) polymerase (PARP) inhibitor olaparib had previously demonstrated effectiveness in a phase II study in patients with prior sensitivity to platinum-based treatments.

Source: Ovarian and Breast Cancer 27. 4. 2020

News Effect of Zolpidem on Sleep Quality and Other Parameters in Patients During the Perioperative Period

Sleep quality is an important factor influencing functional outcomes, pain intensity, and patient satisfaction during the perioperative period. Sleep disturbances are a common problem among patients post-surgery. A prospective study evaluated the effect of zolpidem on sleep quality and other parameters in patients undergoing total hip arthroplasty for advanced osteoarthritis.

Source: Geriatric Patient 9. 9. 2020

Články časopisu Bleeding disorders in pregnancy

Author of the article: J. Procházková, M. Procházka, M. Lubušký Source: Česká gynekologie | 1/2013 1. 3. 2013

News Current NCCN Recommendations for CLL/SLL Diagnosis –⁠ Version 1.2023

In August 2022, the latest guidelines from the National Comprehensive Cancer Network (NCCN) concerning chronic lymphocytic leukemia (CLL) and small lymphocytic lymphoma (SLL) were published. Here we present the essential extract from these recommendations for diagnosing both diseases.

Source: Chronic Lymphocytic Leukemia 23. 11. 2022

News Effects of Metformin on the Cardiovascular System of Patients with Diabetes, but Also Without It

Diabetes mellitus (DM) is considered an independent risk factor for the development of ischemic heart disease (IHD). The prevalence of IHD is continuously increasing, making early detection of risk factors and their elimination crucial in reducing morbidity and mortality of all at-risk patients. Metformin is still recommended as the first-line drug for patients with type 2 DM by experts. In addition to its effects leading to a reduction in blood glucose levels, it also has a cardioprotective effect. Recently, studies focusing on primary and secondary cardiovascular prevention in patients with and without DM have been concentrating on it.

Source: Modern Treatment of Diabetes 5. 10. 2021

News Risk of Thromboembolism in ITP

Among other possible comorbidities in patients with ITP, thromboembolism represents one of the potential issues that require special attention.

Source: Immune Thrombocytopenia 7. 3. 2021

News Is the Quality of Life for Patients with Atrial Fibrillation and Heart Failure Comparable When Treated with Bisoprolol and Digoxin?

The British RATE-AF study, published in December 2020 in the JAMA journal, compared the impact on improving the quality of life in patients with permanent atrial fibrillation (AF) and symptoms of heart failure when administering bisoprolol and low-dose digoxin.

Source: Cardiovascular Continuum 21. 9. 2021

News Meta-analysis of Incidence of Infusion Reactions to Anti-EGFR Antibodies in Patients with mCRC

The application of antibodies against the epidermal growth factor receptor (EGFR), administered in slow infusions mainly as part of the treatment for metastatic colorectal cancer (mCRC), may be accompanied by infusion reactions or hypersensitivity reactions.

Source: Colorectal Cancer 20. 2. 2020

News AI Searches for New Antibiotics in Animal Venoms

The development of new antibiotics has stagnated for several decades for a variety of reasons. However, the use of AI could accelerate and reduce the cost of this process. Thanks to artificial intelligence, scientists are already discovering potential antibiotic sources in animal venoms.

Source: 24. 10. 2025

Články časopisu Sepsis mimics

Author of the article: Thomas Karvunidis, Martin Matějovič Source: Vnitřní lékařství | 6/2019 16. 8. 2019

News ESC 2022: Initiating Gliflozin in HFpEF During Hospitalization Can Benefit the Patient. This is Also Evidenced by Experience from the USA

Based on evidence from clinical studies, gliflozins are currently being introduced into practice for heart failure with preserved ejection fraction (HFpEF) as early as hospitalization. Sharing experiences is therefore very valuable. Several symposia at the ESC 2022 congress focused on the issue of introducing these drugs into HF treatment, some of which also included illustrative case studies. For example, the case of a patient with HFpEF from the USA demonstrated the early initiation of empagliflozin during hospitalization.

Source: Heart Failure 7. 10. 2022

News New Era in Migraine Therapy

Migraine is the most common type of primary headache. It affects about 10% of the world population. Recurring migraine attacks significantly reduce quality of life. Therefore, research in pharmacotherapy in recent years has logically focused on preventing attacks. The result is the latest possibility of biological treatment for migraines using monoclonal antibodies against CGRP receptors.

Source: Migraine 4. 5. 2020

News Current Recommendations of the American Society of Hematology for the Prevention of Thromboembolic Disease and Duration of Prophylaxis in Patients Undergoing Major Surgery

At the end of 2019, new recommendations were published by the American Society of Hematology (ASH) for the prevention of thromboembolic disease (VTE) in hospitalized patients. The new guidelines also addressed the duration of VTE prophylaxis in patients undergoing major surgical procedures.

Source: Prevention of Thrombosis in Surgery 4. 3. 2020

News Summary of Guidelines for the Diagnosis, Prevention, and Treatment of Invasive Fungal Infections in Pediatric Patients with Leukemia and Post Hematopoietic Stem Cell Transplantation

Invasive fungal diseases are a significant cause of morbidity and mortality among immunocompromised pediatric patients with leukemia and post-hematopoietic stem cell transplantation. During the 8th European Conference on Infections in Leukemia (ECIL-8) in 2020, the pediatric group reviewed and updated recommendations for the diagnosis, prevention, and treatment of invasive fungal infections in pediatric patients.

Source: Anti-Infectives 18. 11. 2021

News The Importance of Proper Protein and Calorie Intake in Critically Ill Patients –⁠ Insights from Recent Comparisons

The issue of nutrition, especially proteins, is a crucial aspect affecting the overall health and prognosis of critically ill patients. Two recent studies published in the journals Critical Care and Journal of Parenteral and Enteral Nutrition focused on nutrient intake.

Source: Parenteral Nutrition 14. 11. 2022