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News Programmed Cell Death as a Therapeutic Target in Chronic Lymphocytic Leukemia

One of the key steps in malignant transformation is the disruption of apoptosis. Tumor cells exploit a variety of mechanisms that allow them to evade programmed cell death. Among the drugs targeting apoptosis pathway regulators is venetoclax, a Bcl-2 protein inhibitor used in the treatment of chronic lymphocytic leukemia (CLL). Since August 2021, venetoclax in combination with obinutuzumab can newly be used as a reimbursed therapy for previously untreated patients with CLL who are not suitable for fludarabine administration.

Source: Chronic Lymphocytic Leukemia 10. 8. 2021

News No deficiency of essential fatty acids in home parenteral nutrition

A Dutch-British study, the results of which were published in the Journal of Parenteral and Enteral Nutrition, addressed the issue of potential deficiency of essential fatty acids in patients using home parenteral nutrition.

Source: Parenteral Nutrition 4. 10. 2021

News Efficacy and Safety of Ozanimod in the Treatment of Relapsing-Remitting MS

The sphingosine-1-phosphate receptor (S1PR) modulator ozanimod has recently been approved for the treatment of active relapsing-remitting multiple sclerosis (RRMS). We summarize the current knowledge on its mechanism of action and the results of available studies evaluating its efficacy and safety.

Source: Modulation of S1P in the Treatment of Autoimmune Diseases 9. 5. 2023

News Memantine, Acetylcholinesterase Inhibitors, and Their Combination in the Treatment of Alzheimer's Disease −⁠ Findings from Meta-Analyses

Is memantine, an acetylcholinesterase inhibitor (donepezil), or their combination more advantageous in the therapy of Alzheimer's disease? Two meta-analyses tried to answer this question, and we summarize their conclusions in the following article.

Source: Cognitive in the treatment of Alzheimer's disease 12. 1. 2023

News Prevalence of Depression, Anxiety, and Stress in the Global Population During the COVID-19 Pandemic

A cross-sectional study assessed the prevalence and rate of depression, anxiety, and stress among individuals from various countries around the world during the ongoing COVID-19 pandemic and initial measures to combat the spread of the infection. The impacts on individual subgroups of the population were also analyzed.

Source: Depression and Anxiety 30. 3. 2021

Články časopisu Idiopathic pulmonary fibrosis –⁠ changes in diagnostics and treatment

Author of the article: Vašáková M. Source: Kardiologická revue – Interní medicína | 3/2019 30. 9. 2019

News Pharmacotherapy of Glaucoma in a Nutshell According to the Latest Recommendations of the European Glaucoma Society

The European Glaucoma Society published its latest, 5th version of recommendations for the treatment of glaucoma in 2021. The following text, based on these recommendations, focuses in a nutshell on the basic principles of pharmacotherapy for this disease according to current knowledge.

Source: Treatment of Glaucoma 18. 5. 2023

News What Benefits Do Modern Antidiabetics Bring to Patients in Primary Care?

How has the life of patients who now have the opportunity to treat diabetes mellitus in general practice changed? And what do the current prescription conditions for modern antidiabetics bring to their treating physicians? We discuss this and more with diabetologist MUDr. Katarína Nováková.

Source: Modern Treatment of Diabetes with GLP-1 Analogues 21. 6. 2024

News Mechanisms Connecting Diabetes Mellitus and Obesity

Obesity has a close relationship with insulin resistance and diabetes mellitus (DM); weight gain is associated with a higher incidence of both type 1 and type 2 DM. In the development of type 2 DM, depletion of pancreatic β-cells plays a crucial role, which can no longer produce sufficient insulin to maintain glucose homeostasis. The development of diabetes is much more likely if β-cell failure is accompanied by increased insulin resistance. In obese patients, there is a higher proportion of unsaturated fatty acids, glycerol, pro-inflammatory cytokines, hormones, and other substances in the blood, which have a fundamental impact on insulin resistance.

Source: Diabetes 29. 3. 2020

News CASE STUDIES on the topic of progressing interstitial lung processes

This page serves as a hub for case studies on the topic of progressing interstitial processes. The case studies aim to provide a multidisciplinary view on the rare disease topic of IPP.

Source: Progressive Interstitial Pulmonary Processes 7. 2. 2023

News Simple antiemetic prophylaxis for breast cancer patients treated with AC chemotherapy

The combination of an anthracycline cytostatic agent with cyclophosphamide (AC) is among the highly effective chemotherapy regimens for breast cancer. Individually, these cytostatic agents carry a moderate risk of emetogenicity; however, when combined, they are considered to be at high risk of emesis. The recommended prophylaxis involves administering a 5-HT3 serotonin receptor antagonist in combination with an NK1 neurokinin receptor antagonist and the corticosteroid dexamethasone.

Source: Antiemetic Therapy 23. 9. 2020

News Maintenance treatment with oral olaparib in women with BRCA1/2 mutation and relapsed ovarian cancer

In a phase III study published in the journal Lancet Oncology, data on the effectiveness of olaparib in patients with ovarian cancer and BRCA1/2 mutation were evaluated. The poly(ADP-ribose) polymerase (PARP) inhibitor olaparib had previously demonstrated effectiveness in a phase II study in patients with prior sensitivity to platinum-based treatments.

Source: Ovarian and Breast Cancer 27. 4. 2020

News Effect of Zolpidem on Sleep Quality and Other Parameters in Patients During the Perioperative Period

Sleep quality is an important factor influencing functional outcomes, pain intensity, and patient satisfaction during the perioperative period. Sleep disturbances are a common problem among patients post-surgery. A prospective study evaluated the effect of zolpidem on sleep quality and other parameters in patients undergoing total hip arthroplasty for advanced osteoarthritis.

Source: Geriatric Patient 9. 9. 2020

Články časopisu Bleeding disorders in pregnancy

Author of the article: J. Procházková, M. Procházka, M. Lubušký Source: Česká gynekologie | 1/2013 1. 3. 2013

News Current NCCN Recommendations for CLL/SLL Diagnosis –⁠ Version 1.2023

In August 2022, the latest guidelines from the National Comprehensive Cancer Network (NCCN) concerning chronic lymphocytic leukemia (CLL) and small lymphocytic lymphoma (SLL) were published. Here we present the essential extract from these recommendations for diagnosing both diseases.

Source: Chronic Lymphocytic Leukemia 23. 11. 2022