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News Metamizole at a Glance and in Practice –⁠ Effective Non-Opioid Analgesic for All Ages

The regular webinar of the General Medicine Society of ČLS JEP this spring, besides addressing the current coronavirus situation, also focused on the issue and treatment of pain in its specialized section. Anesthesiologist MUDr. Jan Lejčko from the Pain Treatment Center at KARIM LF UK and FN Plzeň, Vice-President of the Society for the Study and Treatment of Pain ČLS JEP, concentrated on types of pain and principles and options of treatment, particularly using metamizole, in his lecture.
Source: Analgesia 15. 9. 2021

News Metamizole –⁠ wide possibilities of an analgesic with a unique mechanism of action and different routes of administration

Metamizole is a non-addictive pyrazolone analgesic with antipyretic effects, which differs from other non-opioid analgesics by its spasmolytic action. It is indicated in monotherapy and in combinations for the treatment of severe acute and chronic pain. Its high analgesic efficacy is evidenced by a low number of patients needed to treat to achieve at least 50% pain relief in 4-6 hours. The favorable safety profile of metamizole is supported by more than 100 years of clinical experience.
Source: Analgesia 30. 5. 2024

News 10 Properties and Benefits of Gliptins: How They Work and When to Prescribe Them

General practitioners can now prescribe oral antidiabetics from the group of gliptins to patients with type 2 diabetes. Their therapeutic options are significantly expanded in the care of these patients. In the following text, we briefly summarize the mechanism of action of gliptins and their advantages over other oral antidiabetics.
Source: Diabetes 28. 8. 2020

News The Wound Healing Process Step by Step and What Can Complicate It

Proper care of injuries is a fundamental prerequisite for their successful healing. Knowing the individual phases of healing facilitates treatment and helps prevent the most common complications.
Source: Wound Healing 2. 12. 2020

News How to Detect COPD Early in Primary Care?

Chronic obstructive pulmonary disease (COPD) can be present even in individuals without obvious subjective symptoms, or the emerging symptoms may be overlooked by both the patient and the doctor due to their very gradual development. So, what is the path to early detection of COPD in primary care, and how can this disease be distinguished from others accompanied by similar manifestations?
Source: Treatment of Asthma and COPD 6. 4. 2022

News State of the Intestinal Microbiome and COVID-19 Infection −⁠ Possible Correlations

Some patients infected with the SARS-CoV-2 virus exhibit gastrointestinal symptoms, including diarrhea, during the course of COVID-19. Current knowledge suggests that COVID-19 symptoms are related, among other things, to the intestinal microbiome. Could the use of probiotics therefore act as a prevention of this disease or its more severe course?
Source: GI, colic and microbiome 16. 2. 2021

News Depakine Chrono versus Other Valproates in the Treatment of Bipolar Disorder

Bipolar disorder is among the most severe psychiatric illnesses, and if not treated properly, it can negatively affect the patient's quality of life. Does switching therapy from other valproates to Depakine Chrono lead to better outcomes in treating this disease? The following study aimed to find the answer to this question.
Source: Bipolar Disorder 18. 11. 2020

News More Patients Will Now Have Access to Incontinence Aids

Since December of last year, new rules have been in effect for the prescription of medical aids prescribed through vouchers, including aids for urine collection and voiding. The new rules are governed by the current wording of Act No. 48/1997 Coll., on Public Health Insurance, which also includes a new categorization tree (Appendix No. 3 to the Act).
Source: Incontinence 3. 3. 2020

News Negative Symptoms of Schizophrenia and Their Assessment

Schizophrenia is a serious psychiatric disorder with a prevalence of up to 1%. It can manifest with both negative and positive symptoms. We briefly summarize the clinical assessment and rating scales of negative symptoms in the following text.
Source: Schizophrenia and Antipsychotics 14. 7. 2021

News Side Effects of Antipsychotics and Patient Preferences in the Treatment of Schizophrenia

Although a number of antipsychotics are currently available, many patients still suffer from unpleasant side effects associated with the treatment of schizophrenia. To determine how individuals with schizophrenia and schizoaffective disorders perceive antipsychotic treatment, a larger survey was conducted in the USA in 2016.
Source: Modern Treatment of Schizophrenia 9. 10. 2023

Journal articles Peritoneal Carcinomatosis of Gastric Origin –⁠ Treatment Possibilities

Author of the article: David Hoskovec, Zdeněk Krška, Petr Dytrych, Michal Vočka Source: Klinická onkologie | 5/2019 14. 10. 2019

Journal articles Adult-onset Still’s disease –⁠ a difficult path to diagnosis through fever and effusions of unknown origin

Author of the article: Jana Malegová, Lukáš Koten, Pavel Horák Source: Vnitřní lékařství | 5-6/2014 28. 6. 2014

Journal articles Iron metabolism and its regulations

Author of the article: D. Vyoral, J. Petrák Source: Vnitřní lékařství | Suppl 2/2012 17. 8. 2012

News Deficit dihydropyrimidine dehydrogenase and its association with 5-fluorouracil toxicity

Deficit dihydropyrimidine dehydrogenase (DPD) is a risk factor for severe toxicity of 5-fluorouracil (5-FU). Below, we summarize current knowledge regarding the identification of patients with pathogenic variants of the DPYD gene and study results concerning the safety of therapy with respect to dose individualization based on genotyping.
Source: Genetics 12. 6. 2023

News Hybrid Cooperating Complexes in Osteoarthritis Treatment

Intra-articular application of corticosteroids and hyaluronic acid is part of the treatment of osteoarthritis (OA) in patients for whom oral or topical treatment does not provide sufficient response. The following text addresses the lubricating and protective properties of synovial fluid and the associated choice of suitable intra-articular viscosupplementation, with an emphasis on innovative molecules with high concentrations of hyaluronic acid and low viscosity.
Source: Pain Management 21. 6. 2024

News Diosmin and Hesperidin: What Does Pharmacokinetics Show?

Flavonoids are plant-derived compounds that have a number of beneficial pharmacological effects. Among the most well-known flavonoids, alongside rutin, are diosmin and hesperidin, which are used as venotonics and vasoprotectives in chronic venous insufficiency (CVI).
Source: Venous Insufficiency 23. 4. 2020

Journal articles Acute kidney injury in patients with acute pancreatitis

Author of the article: N. Petejová, Arnošt Martínek, V. Teplan Source: Gastroenterologie a hepatologie | 2/2018 4. 5. 2018

News Monitoring Limits in Prescribing Incontinence Aids is Essential

The amendment to the Public Health Insurance Act, which came into effect in December 2019, brought many changes in the reimbursement of medical aids through prescriptions. The methodology for determining the degree of incontinence has changed, and it is now also possible to combine aids according to the individual needs of the patient. We summarize other novelties related to limits issues in the following text.
Source: Incontinence 29. 2. 2020

News Pregabalin in the Hands of a General Practitioner

A recent Cochrane systematic review by authors from Oxford University examined the effect of pregabalin in the treatment of postherpetic neuralgia and diabetic neuropathy –⁠ conditions that general practitioners frequently encounter in their practice. Is pregabalin a suitable choice in these indications?
Source: Neuropathic Pain 18. 2. 2020

News Treatment of Cough in Clinical Practice: Which Preparations Are Suitable and When?

In clinical practice, we differentiate the treatment of non-productive and moist productive cough. When choosing appropriate therapy, we consider the characteristics of the available medicinal products, such as sedation, route of administration, potentiation of antibiotic effect, or anti-inflammatory effect. Combining antitussive and expectorant in one dose is irrational in any case. So, how should one proceed in the treatment of cough correctly?
Source: Cough Therapy 15. 2. 2022

Journal articles Treatment of pelvic avulsion fractures in children and adolescents

Author of the article: A. Stančák, J. Kautzner, T. Trč, V. Havlas Source: Rozhledy v chirurgii | 4/2017 23. 5. 2017

Journal articles Periodic fevers and other autoinflammatory diseases

Author of the article: Šárka Fingerhutová, Eva Jančová, Markéta Tesařová, Lenka Dvořáková, Pavla Doležalová Source: Časopis lékařů českých | 3/2018 27. 6. 2018

News Causes, Consequences, and Solutions to Weight Gain in Schizophrenia Treatment

The use of antipsychotics in the treatment of schizophrenia is often associated with the development of overweight and obesity, which poses a risk for the onset of many diseases and increases morbidity and mortality in these patients. Concern about weight gain is also a common reason for non-adherence to antipsychotic treatment. The cause of weight gain may also lie in the symptoms of the disease itself. We, therefore, provide a summary of the causes, consequences, and possible solutions to this undesirable impact of schizophrenia and its treatment.
Source: Modern Treatment of Schizophrenia 13. 3. 2024

News Maintenance Therapy of a Female Patient with AML After Intense Chemotherapy –⁠ Case Study

The following case study presents the case of a female patient with acute myeloid leukemia (AML) who experienced life-threatening complications after the second consolidation chemotherapy, rendering her incapable of undergoing further intense therapy or allogeneic HSCT. In this situation, maintenance therapy with oral azacitidine proved beneficial –⁠ this modality, due to its good tolerance, can be used as a bridge until allo-HSCT can be performed in patients in poor clinical condition.
Source: Acute Myeloid Leukemia 10. 5. 2024

News Wound Healing and Exudate –⁠ A Comprehensive Look at Moisture Management in Wounds

Exudate produced during the inflammatory phase of healing is a crucial factor that ensures a moist environment in the wound, provides nutrients for cellular metabolism, and supports autolytic debridement. Without proper exudate management and maintenance of optimal moisture in the wound, patients are exposed to a range of risks and complications in healing.
Source: Wound Healing 14. 12. 2023

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